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An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals
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dc.contributor.author | Sharma, Sunil V. | |
dc.contributor.author | Pubill-Ulldemolins, Cristina | |
dc.contributor.author | Marelli, Enrico | |
dc.contributor.author | Goss, Rebecca J. M. | |
dc.date.accessioned | 2021-08-24T08:30:02Z | |
dc.date.available | 2021-08-24T08:30:02Z | |
dc.date.issued | 2021-10-21 | |
dc.identifier | 275579146 | |
dc.identifier | fd7c4871-4d82-4e7b-8caf-6bf16e8f0d14 | |
dc.identifier | 000686257200001 | |
dc.identifier | 85117387495 | |
dc.identifier.citation | Sharma , S V , Pubill-Ulldemolins , C , Marelli , E & Goss , R J M 2021 , ' An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals ' , Organic Chemistry Frontiers , vol. 8 , no. 20 , pp. 5722-5727 . https://doi.org/10.1039/D1QO00919B | en |
dc.identifier.issn | 2052-4129 | |
dc.identifier.other | Bibtex: D1QO00919B | |
dc.identifier.uri | https://hdl.handle.net/10023/23820 | |
dc.description | The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013/ERC grant agreement no 614779 GenoChemetics (to R.J.M.G). | en |
dc.description.abstract | The development of mild, aqueous conditions for the cross-coupling of highly functionalized (hetero)aryl chlorides or bromides is attractive, enabling their functionalization and diversification. Herein, we report a general method for Suzuki–Miyaura cross-coupling at 37 °C in aqueous media in the presence of air. We demonstrate application of this general methodology for derivatisation of (poly)chlorinated, medicinally active compounds and halogenated amino acids. The approach holds the potential to be a useful tool for late-stage functionalization or analogue generation. | |
dc.format.extent | 1420982 | |
dc.language.iso | eng | |
dc.relation.ispartof | Organic Chemistry Frontiers | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.title | An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals | en |
dc.type | Journal article | en |
dc.contributor.sponsor | European Research Council | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | 10.1039/D1QO00919B | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | GCGXC | en |
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