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dc.contributor.authorSharma, Sunil V.
dc.contributor.authorPubill-Ulldemolins, Cristina
dc.contributor.authorMarelli, Enrico
dc.contributor.authorGoss, Rebecca J. M.
dc.date.accessioned2021-08-24T08:30:02Z
dc.date.available2021-08-24T08:30:02Z
dc.date.issued2021-08-19
dc.identifier.citationSharma , S V , Pubill-Ulldemolins , C , Marelli , E & Goss , R J M 2021 , ' An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals ' , Organic Chemistry Frontiers , vol. Advance Article . https://doi.org/10.1039/D1QO00919Ben
dc.identifier.issn2052-4129
dc.identifier.otherPURE: 275579146
dc.identifier.otherPURE UUID: fd7c4871-4d82-4e7b-8caf-6bf16e8f0d14
dc.identifier.otherBibtex: D1QO00919B
dc.identifier.otherWOS: 000686257200001
dc.identifier.urihttp://hdl.handle.net/10023/23820
dc.descriptionThe research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013/ERC grant agreement no 614779 GenoChemetics (to R.J.M.G).en
dc.description.abstractThe development of mild, aqueous conditions for the cross-coupling of highly functionalized (hetero)aryl chlorides or bromides is attractive, enabling their functionalization and diversification. Herein, we report a general method for Suzuki–Miyaura cross-coupling at 37 °C in aqueous media in the presence of air. We demonstrate application of this general methodology for derivatisation of (poly)chlorinated, medicinally active compounds and halogenated amino acids. The approach holds the potential to be a useful tool for late-stage functionalization or analogue generation.
dc.language.isoeng
dc.relation.ispartofOrganic Chemistry Frontiersen
dc.rightsCopyright © The Author(s). Open Access. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleAn expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticalsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1039/D1QO00919B
dc.description.statusPeer revieweden


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