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dc.contributor.authorOller, Laura
dc.contributor.authorBennett, Kimberley A.
dc.contributor.authorMcKnight, J. Chris
dc.contributor.authorMoss, Simon E.W.
dc.contributor.authorMilne, Ryan
dc.contributor.authorHall, Ailsa J.
dc.contributor.authorRocha, Joel
dc.date.accessioned2021-08-20T14:30:09Z
dc.date.available2021-08-20T14:30:09Z
dc.date.issued2021-08-19
dc.identifier.citationOller , L , Bennett , K A , McKnight , J C , Moss , S E W , Milne , R , Hall , A J & Rocha , J 2021 , ' Partial pressure of oxygen in adipose tissue and its relationship with fatness in a natural animal model of extreme fat deposition, the grey seal ' , Physiological Reports , vol. 9 , no. 16 , e14972 . https://doi.org/10.14814/phy2.14972en
dc.identifier.issn2051-817X
dc.identifier.otherPURE: 275538724
dc.identifier.otherPURE UUID: f9a5f5fd-ff8f-48aa-b117-c0df9d840c10
dc.identifier.otherRIS: urn:4A47CD8DFAFE0A7515D4AC908714C8F1
dc.identifier.otherORCID: /0000-0002-7562-1771/work/98785472
dc.identifier.otherORCID: /0000-0002-3872-4886/work/99804603
dc.identifier.otherScopus: 85113364828
dc.identifier.otherWOS: 000687982300011
dc.identifier.urihttp://hdl.handle.net/10023/23806
dc.descriptionFunding: This study and LO were funded by Abertay University R- LINCS studentship. UKRI Natural Environment Research Council (NERC) (SMRU 1001, NE/M01357X/1 and NE/M013723/1) covered animal capture/release and husbandry.en
dc.description.abstractExcessive adiposity is associated with altered oxygen tension and comorbidities in humans. In contrast, marine mammals have high adiposity with no apparent detrimental effects. However, partial pressure of oxygen (Po2) in their subcutaneous adipose tissue (blubber) and its relationship with fatness have not been reported. We measured Po2 and temperature at different blubber depths in 12 healthy juvenile grey seals. Fatness was estimated from blubber thickness and morphometric parameters. Simultaneously, we monitored breathing pattern; heart rate and arterial blood saturation with a pulse oximeter; and relative changes in total hemoglobin, deoxyhemoglobin, and oxyhemoglobin in blubber capillaries using near-infrared spectroscopy (NIRS) as proxies for local oxygenation changes. Blubber Po2 ranged from 14.5 to 71.4 mmHg (39.2 ± 14.1 mmHg), which is similar to values reported in other species. Blubber Po2 was strongly and negatively associated with fatness (LME: p < 0.0001, R2marginal = 0.53, R2conditional = 0.64, n = 10), but not with blubber depth. No other parameters explained variability in Po2, suggesting arterial blood and local oxygen delivery did not vary within and between measurements. The fall in blubber Po2 with increased fatness in seals is consistent with other animal models of rapid fat deposition. However, the Po2 levels at which blubber becomes hypoxic and consequences of low blubber Po2 for its health and function, particularly in very fat individuals, remain unknown. How seals avoid detrimental effects of low oxygen tension in adipose tissue, despite their high and fluctuating adiposity, is a fruitful avenue to explore.
dc.format.extent15
dc.language.isoeng
dc.relation.ispartofPhysiological Reportsen
dc.rightsCopyright © 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectAdiposityen
dc.subjectBlubberen
dc.subjectMarine mammalsen
dc.subjectNIRSen
dc.subjectOxygenationen
dc.subjectPo2en
dc.subjectTemperatureen
dc.subjectGC Oceanographyen
dc.subjectQL Zoologyen
dc.subjectQP Physiologyen
dc.subjectDASen
dc.subject.lccGCen
dc.subject.lccQLen
dc.subject.lccQPen
dc.titlePartial pressure of oxygen in adipose tissue and its relationship with fatness in a natural animal model of extreme fat deposition, the grey sealen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Sea Mammal Research Uniten
dc.contributor.institutionUniversity of St Andrews.Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.identifier.doihttps://doi.org/10.14814/phy2.14972
dc.description.statusPeer revieweden


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