Cost burden of Clostridioides difficile infection to the health service : a retrospective cohort study in Scotland
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Background Clostridioides difficile infection (CDI) is associated with high healthcare demands and related costs. Aim To evaluate the healthcare and economic burden of CDI in hospitalised patients with community- (HOCA-CDI) or hospital-associated CDI (HOHA-CDI) in the National Health Service in Scotland. Methods A retrospective cohort study was conducted, examining data between August 2010 and July 2013 from four patient-level Scottish datasets, linked to death data. Data examined included prior antimicrobial prescriptions in the community, hospitalisations, length of stay and mortality. Each CDI case was matched to three hospital-based controls on the basis of age, gender, hospital and date of admission. Descriptive economic evaluations were based on bed-day costs for different types of wards. Findings Overall, 3304 CDI cases were included in the study. CDI was associated with additional median lengths of stay of 7.2 days for HOCA-CDI and 12.0 days for HOHA-CDI compared with their respective, matched controls. The 30-day mortality rate was 6.8% for HOCA-CDI and 12.4% for HOHA-CDI. Overall, recurrence within 90 days of the first CDI episode occurred in 373/2740 (13.6%) survivors. The median additional expenditure for each initial CDI case compared with matched controls was £1713. In the 6 months after the index hospitalisation, the cost associated with a CDI case was £5126 higher than for controls. Conclusion Using routinely collected national data, we demonstrate the substantial burden of CDI on healthcare services, including lengthy hospital stays and readmissions, which increase the costs of managing patients with CDI compared with matched controls.
Robertson , C , Pan , J , Kavanagh , K , Ford , I , McCowan , C , Bennie , M , Marwick , C & Leanord , A 2020 , ' Cost burden of Clostridioides difficile infection to the health service : a retrospective cohort study in Scotland ' , Journal of Hospital Infection , vol. In press . https://doi.org/10.1016/j.jhin.2020.07.019
Journal of Hospital Infection
Copyright © 2020 Published by Elsevier Ltd on behalf of The Healthcare Infection Society. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.jhin.2020.07.019.
DescriptionFunding: Astellas Pharma, Inc.
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