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dc.contributor.authorHescham, S
dc.contributor.authorJahanashahi, A
dc.contributor.authorSchweimer, Judith
dc.contributor.authorMitchel, SN
dc.contributor.authorCarter, G
dc.contributor.authorBlokland, A
dc.contributor.authorSharp, T
dc.contributor.authorTemel, Y
dc.identifier.citationHescham , S , Jahanashahi , A , Schweimer , J , Mitchel , SN , Carter , G , Blokland , A , Sharp , T & Temel , Y 2016 , ' Fornix deep brain stimulation enhances acetylcholine levels in the hippocampus ' , Brain Structure and Function , vol. 221 , pp. 4281-4286 .
dc.identifier.otherPURE: 275052761
dc.identifier.otherPURE UUID: 705e63c4-12da-4fee-a3af-1026c3d13856
dc.identifier.otherScopus: 84947902736
dc.identifier.otherORCID: /0000-0002-5968-3534/work/108119018
dc.description.abstractDeep brain stimulation (DBS) of the fornix has gained interest as a potential therapy for advanced treatment-resistant dementia, yet the mechanism of action remains widely unknown. Previously, we have reported beneficial memory effects of fornix DBS in a scopolamine induced rat model of dementia, which is dependent on various brain structures including hippocampus. To elucidate mechanisms of action of fornix DBS with regard to memory restoration, we performed c-Fos immunohistochemistry in the hippocampus. We found that fornix DBS induced a selective activation of cells in the CA1 and CA3 subfields of the dorsal hippocampus. In addition, hippocampal neurotransmitter levels were measured using microdialysis before, during and after 60 min of fornix DBS in a next experiment. We observed a substantial increase in the levels of extracellular hippocampal acetylcholine, which peaked 20 min after stimulus onset. Interestingly, hippocampal glutamate levels did not change compared to baseline. Therefore, our findings provide first experimental evidence that fornix DBS activates the hippocampus and induces the release of acetylcholine in this region.
dc.relation.ispartofBrain Structure and Functionen
dc.rightsCopyright © The Author(s) 2015. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en
dc.subjectDeep brain stimulationen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleFornix deep brain stimulation enhances acetylcholine levels in the hippocampusen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.description.statusPeer revieweden

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