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dc.contributor.authorEadie, Ewan
dc.contributor.authorO’Mahoney, Paul
dc.contributor.authorFinlayson, Louise
dc.contributor.authorBarnard, Isla Rose Mary
dc.contributor.authorIbbotson, Sally Helen
dc.contributor.authorWood, Kenneth
dc.identifier.citationEadie , E , O’Mahoney , P , Finlayson , L , Barnard , I R M , Ibbotson , S H & Wood , K 2021 , ' Computer modeling indicates dramatically less DNA damage from far-UVC krypton chloride lamps (222 nm) than from sunlight exposure ' , Photochemistry and Photobiology , vol. Early View .
dc.identifier.otherPURE: 274800173
dc.identifier.otherPURE UUID: 1392c699-8957-4cd6-9de4-cf40e9b1a4b6
dc.identifier.otherRIS: urn:2AC6B4A62F646A7596361FA53B0E2E19
dc.identifier.otherWOS: 000669629500001
dc.identifier.otherScopus: 85117166164
dc.descriptionFunding: Dr Paul O’Mahoney is funded by Medi-lase (registered charity SC037390) and the Alfred Stewart Trust. Dr Isla Barnard acknowledges financial support from an UK EPRSC PhD studentship (EP/N509759/1) and Louise Finlayson acknowledges financial support from EPSRC Industrial Doctorate Centre Scheme (2262922) and the Laser Research and Therapy Fund (registered charity SC030850).en
dc.description.abstractThis study aims to investigate, with computer modeling, the DNA damage (assessed by cyclobutane pyrimidine dimer (CPD) formation) from far-ultraviolet C (far-UVC) in comparison with sunlight exposure in both a temperate (Harwell, England) and Mediterranean (Thessaloniki, Greece) climate. The research utilizes the published results from Barnard et al. [Barnard, I.R.M (2020) Photodermatol. Photoimmunol. Photomed. 36, 476?477] to determine the relative CPD yield of unfiltered and filtered far-UVC and sunlight exposure. Under current American Conference of Governmental Industrial Hygienists (ACGIH) exposure limits, 10 minutes of sunlight at an ultraviolet (UV) Index of 4 ? typical throughout the day in a temperate climate from Spring to Autumn - produces equivalent numbers of CPD as 700 hours of unfiltered far-UVC or more than 30,000 hours of filtered far-UVC at the basal layer. At the top of the epidermis these values are reduced to 30 and 300 hours respectively. In terms of DNA damage induction, as assessed by CPD formation, the risk from sunlight exposure greatly exceeds the risk from far-UVC. However the photochemistry that will occur in the stratum corneum from absorption of the vast majority of the high energy far-UVC photons is unknown, as are the consequences.
dc.relation.ispartofPhotochemistry and Photobiologyen
dc.rightsCopyright © 2021 The Authors. Photochemistry and Photobiology published by Wiley Periodicals LLC on behalf of American Society for Photobiology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectQA Mathematicsen
dc.subjectQH426 Geneticsen
dc.titleComputer modeling indicates dramatically less DNA damage from far-UVC krypton chloride lamps (222 nm) than from sunlight exposureen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews.Centre for Biophotonicsen
dc.description.statusPeer revieweden

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