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The regulatory roles of motile cilia in CSF circulation and hydrocephalus
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dc.contributor.author | Kumar, Vijay | |
dc.contributor.author | Umair, Zobia | |
dc.contributor.author | Kumar, Shiv | |
dc.contributor.author | Goutam, Ravi Shankar | |
dc.contributor.author | Park, Soochul | |
dc.contributor.author | Kim, Jaebong | |
dc.date.accessioned | 2021-07-13T14:30:09Z | |
dc.date.available | 2021-07-13T14:30:09Z | |
dc.date.issued | 2021-07-07 | |
dc.identifier | 274972469 | |
dc.identifier | 7b3495e1-c3ad-48e8-9f6c-4c7e143b113e | |
dc.identifier | 000671339500001 | |
dc.identifier | 85109657690 | |
dc.identifier.citation | Kumar , V , Umair , Z , Kumar , S , Goutam , R S , Park , S & Kim , J 2021 , ' The regulatory roles of motile cilia in CSF circulation and hydrocephalus ' , Fluids and Barriers of the CNS , vol. 18 , 31 . https://doi.org/10.1186/s12987-021-00265-0 | en |
dc.identifier.issn | 2045-8118 | |
dc.identifier.other | RIS: urn:8E95BF695D84899C62919DA3BEBD9C3A | |
dc.identifier.other | RIS: Kumar2021 | |
dc.identifier.uri | https://hdl.handle.net/10023/23535 | |
dc.description | This article was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education, Science, and Technology of Korea (2016R1D1A1B02008770, 2016M3A9B8914057, 2018M3C7A1056285, and 2021R1A4A1027355). | en |
dc.description.abstract | Background Cerebrospinal fluid (CSF) is an ultra-filtrated colorless brain fluid that circulates within brain spaces like the ventricular cavities, subarachnoid space, and the spine. Its continuous flow serves many primary functions, including nourishment, brain protection, and waste removal. Main body The abnormal accumulation of CSF in brain cavities triggers severe hydrocephalus. Accumulating evidence had indicated that synchronized beats of motile cilia (cilia from multiciliated cells or the ependymal lining in brain ventricles) provide forceful pressure to generate and restrain CSF flow and maintain overall CSF circulation within brain spaces. In humans, the disorders caused by defective primary and/or motile cilia are generally referred to as ciliopathies. The key role of CSF circulation in brain development and its functioning has not been fully elucidated. Conclusions In this review, we briefly discuss the underlying role of motile cilia in CSF circulation and hydrocephalus. We have reviewed cilia and ciliated cells in the brain and the existing evidence for the regulatory role of functional cilia in CSF circulation in the brain. We further discuss the findings obtained for defective cilia and their potential involvement in hydrocephalus. Furthermore, this review will reinforce the idea of motile cilia as master regulators of CSF movements, brain development, and neuronal diseases. | |
dc.format.extent | 11 | |
dc.format.extent | 1491807 | |
dc.language.iso | eng | |
dc.relation.ispartof | Fluids and Barriers of the CNS | en |
dc.subject | Cerebrospinal fluid | en |
dc.subject | Cilia | en |
dc.subject | Ependymal cells | en |
dc.subject | Brain development | en |
dc.subject | Ciliary motility | en |
dc.subject | Brain ventricular system | en |
dc.subject | Hydrocephalus | en |
dc.subject | Cilipathies | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | T-NDAS | en |
dc.subject.lcc | RC0321 | en |
dc.title | The regulatory roles of motile cilia in CSF circulation and hydrocephalus | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Psychology and Neuroscience | en |
dc.identifier.doi | https://doi.org/10.1186/s12987-021-00265-0 | |
dc.description.status | Peer reviewed | en |
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