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dc.contributor.advisorFlorence, Gordon John
dc.contributor.authorFreire de Araujo Gouy, Rodrigo Pierre
dc.coverage.spatialxviii, 250 p.en_US
dc.date.accessioned2021-07-13T12:48:03Z
dc.date.available2021-07-13T12:48:03Z
dc.date.issued2021-06-30
dc.identifier.urihttp://hdl.handle.net/10023/23533
dc.description.abstractChapter 1 – Introduction of neglected tropical diseases, their impact in our society, treatments, and current challenges. We further explore how a limited understanding of these diseases impedes their treatments. Identification of novel compounds and targets as well as repurposing of previously developed promising drug candidates, may lead to improvement of current treatments methods. Chapter 2 – Nitro heteroaromatic compounds have demonstrated their potential through their recurrent use as antiparasitic treatments. The novel series of nitro containing heteroaromatics moieties presented in this work were designed to further explore their antiparasitic potential and improve the series for the use in target identification studies. Chapter 3 – Fumagillin, a natural product isolated from Aspergillus fumigatus, has recently been found to be a promising antiparasitic drug candidate. Its target in mammalian cell lines has been found to be the enzyme MetAP2, however its target in trypanosomatids parasite is yet to be confirmed. In this chapter, we discuss the development of a new series of fumagillin analogues with increased antiparasitic potential. The determined SAR is further applied in the synthesis of probes for imaging and photo-affinity labelling suitable for target identification. Chapter 4 – Summary of the synthesised compounds for both series and biological data obtained throughout this work, and discussion of further work on both series towards novel analogues with antiparasitic potential.en_US
dc.description.sponsorship"This work was supported by the University of St Andrews through the Brazilian Friendship Scholarship" -- Fundingen
dc.language.isoenen_US
dc.publisherUniversity of St Andrews
dc.relationDesign and synthesis of novel synthetic and natural product inspired trypanosomatid inhibitors (thesis data) Freire De Araujo Gouy, R.P., University of St Andrews. DOI: https://doi.org/10.17630/e1a51dd1-0e30-4314-a15b-6344629af167en
dc.relation.urihttps://doi.org/10.17630/e1a51dd1-0e30-4314-a15b-6344629af167
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeglected tropical diseasesen_US
dc.subjectTrypanosomiasisen_US
dc.subjectNatural productsen_US
dc.subjectFumagillinen_US
dc.subjectNitro heteroaromaticen_US
dc.subjectTarget identificationen_US
dc.subject.lccRM412.F84
dc.subject.lcshAntiparasitic agents--Designen
dc.subject.lcshTropical medicineen
dc.subject.lcshNatural productsen
dc.subject.lcshTrypanosomiasisen
dc.titleDesign and synthesis of novel synthetic and natural product inspired trypanosomatid inhibitorsen_US
dc.typeThesisen_US
dc.contributor.sponsorUniversity of St Andrews. Brazilian Friendship Scholarshipen_US
dc.type.qualificationlevelDoctoralen_US
dc.type.qualificationnamePhD Doctor of Philosophyen_US
dc.publisher.institutionThe University of St Andrewsen_US
dc.rights.embargodate2024-04-09
dc.rights.embargoreasonThesis restricted in accordance with University regulations. Print and electronic copy restricted until 9th April 2024en
dc.identifier.doihttps://doi.org/10.17630/sta/103


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    Except where otherwise noted within the work, this item's licence for re-use is described as Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International