Escitalopram restores reversal learning impairments in rats with lesions of orbital frontal cortex
MetadataShow full item record
The term ‘cognitive structures’ is used to describe the fact that mental models underlie thinking, reasoning and representing. Cognitive structures generally improve the efficiency of information processing by providing a situational framework within which there are parameters governing the nature and timing of information and appropriate responses can be anticipated. Unanticipated events that violate the parameters of the cognitive structure require the cognitive model to be updated, but this comes at an efficiency cost. In reversal learning a response that had been reinforced is no longer reinforced, while an alternative is now reinforced, having previously not been (A+/B− becomes A−/B+). Unanticipated changes of contingencies require that cognitive structures are updated. In this study, we examined the effect of lesions of the orbital frontal cortex (OFC) and the effects of the selective serotonin reuptake inhibitor (SSRI), escitalopram, on discrimination and reversal learning. Escitalopram was without effect in intact rats. Rats with OFC lesions had selective impairment of reversal learning, which was ameliorated by escitalopram. We conclude that reversal learning in OFC-lesioned rats is an easily administered and sensitive test that can detect effects of serotonergic modulation on cognitive structures that are involved in behavioural flexibility.
Tait , D S , Bowman , E E , Miller , S , Dovlatyan , M , Sanchez , C & Brown , V J 2021 , Escitalopram restores reversal learning impairments in rats with lesions of orbital frontal cortex . in S Löbner , T Gamerschlag , T Kalenscher , M Schrenk & H Zeevat (eds) , Concepts, frames and cascades in semantics, cognition and ontology . Language, cognition, and mind , vol. 7 , Springer , Cham , pp. 389-409 . https://doi.org/10.1007/978-3-030-50200-3_18
Concepts, frames and cascades in semantics, cognition and ontology
Copyright © The Author(s) 2021. This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. The images or other third party material in this chapter are included in the chapter's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
DescriptionThis study was funded by H. Lundbeck A/S.
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.