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dc.contributor.authorVasileiou, Eleftheria
dc.contributor.authorSimpson, Colin R
dc.contributor.authorShi, Ting
dc.contributor.authorKerr, Steven
dc.contributor.authorAgrawal, Utkarsh
dc.contributor.authorAkbari, Ashley
dc.contributor.authorBedston, Stuart
dc.contributor.authorBeggs, Jillian
dc.contributor.authorBradley, Declan
dc.contributor.authorChuter, Antony
dc.contributor.authorde Lusignan, Simon
dc.contributor.authorDocherty, Annemarie B
dc.contributor.authorFord, David
dc.contributor.authorHobbs, FD Richard
dc.contributor.authorJoy, Mark
dc.contributor.authorKatikireddi, Srinivasa Vittal
dc.contributor.authorMarple, James
dc.contributor.authorMcCowan, Colin
dc.contributor.authorMcGagh, Dylan
dc.contributor.authorMcMenamin, Jim
dc.contributor.authorMoore, Emily
dc.contributor.authorMurray, Josephine LK
dc.contributor.authorPan, Jiafeng
dc.contributor.authorRitchie, Lewis
dc.contributor.authorShah, Syed Ahmar
dc.contributor.authorStock, Sarah
dc.contributor.authorTorabi, Fatemeh
dc.contributor.authorTsang, Ruby SM
dc.contributor.authorWood, Rachael
dc.contributor.authorWoolhouse, Mark
dc.contributor.authorRobertson, Chris
dc.contributor.authorSheikh, Aziz
dc.date.accessioned2021-06-11T10:30:04Z
dc.date.available2021-06-11T10:30:04Z
dc.date.issued2021-05-01
dc.identifier.citationVasileiou , E , Simpson , C R , Shi , T , Kerr , S , Agrawal , U , Akbari , A , Bedston , S , Beggs , J , Bradley , D , Chuter , A , de Lusignan , S , Docherty , A B , Ford , D , Hobbs , FD R , Joy , M , Katikireddi , S V , Marple , J , McCowan , C , McGagh , D , McMenamin , J , Moore , E , Murray , J LK , Pan , J , Ritchie , L , Shah , S A , Stock , S , Torabi , F , Tsang , R SM , Wood , R , Woolhouse , M , Robertson , C & Sheikh , A 2021 , ' Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland : a national prospective cohort study ' , The Lancet , vol. 397 , no. 10285 , pp. 1646-1657 . https://doi.org/10.1016/S0140-6736(21)00677-2en
dc.identifier.issn0037-9808
dc.identifier.otherPURE: 273372735
dc.identifier.otherPURE UUID: 33a55e67-e437-493f-b1ce-cdbcfac781aa
dc.identifier.otherRIS: urn:3C589A96628D62B07A0233305E6BCE77
dc.identifier.otherRIS: urn:3C589A96628D62B07A0233305E6BCE77
dc.identifier.otherScopus: 85104923342
dc.identifier.otherORCID: /0000-0002-9466-833X/work/95772778
dc.identifier.urihttp://hdl.handle.net/10023/23345
dc.descriptionEAVE II is funded by the Medical Research Council (MR/R008345/1) with the support of BREATHE—The Health Data Research Hub for Respiratory Health (MC_PC_19004), which is funded through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. Additional support has been provided through Public Health Scotland and the Scottish Government's director-general of Health and Social Care. FDRH acknowledges part support from the National Institutes of Health Research (NIHR) School for Primary Care Research, the NIHR Collaboration for Leadership in Applied Health Research and Care Oxford, and the NIHR Oxford Biomedical Research Centre. SVK acknowledges funding from an NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_00022/2), and Scottish Government Chief Scientist Office (SPHSU13).en
dc.description.abstractBackground The BNT162b2 mRNA (Pfizer–BioNTech) and ChAdOx1 nCoV-19 (Oxford–AstraZeneca) COVID-19 vaccines have shown high efficacy against disease in phase 3 clinical trials and are now being used in national vaccination programmes in the UK and several other countries. Studying the real-world effects of these vaccines is an urgent requirement. The aim of our study was to investigate the association between the mass roll-out of the first doses of these COVID-19 vaccines and hospital admissions for COVID-19.  Methods We did a prospective cohort study using the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19—EAVE II—database comprising linked vaccination, primary care, real-time reverse transcription-PCR testing, and hospital admission patient records for 5·4 million people in Scotland (about 99% of the population) registered at 940 general practices. Individuals who had previously tested positive were excluded from the analysis. A time-dependent Cox model and Poisson regression models with inverse propensity weights were fitted to estimate effectiveness against COVID-19 hospital admission (defined as 1–adjusted rate ratio) following the first dose of vaccine.  Findings Between Dec 8, 2020, and Feb 22, 2021, a total of 1 331 993 people were vaccinated over the study period. The mean age of those vaccinated was 65·0 years (SD 16·2). The first dose of the BNT162b2 mRNA vaccine was associated with a vaccine effect of 91% (95% CI 85–94) for reduced COVID-19 hospital admission at 28–34 days post-vaccination. Vaccine effect at the same time interval for the ChAdOx1 vaccine was 88% (95% CI 75–94). Results of combined vaccine effects against hospital admission due to COVID-19 were similar when restricting the analysis to those aged 80 years and older (83%, 95% CI 72–89 at 28–34 days post-vaccination).  Interpretation Mass roll-out of the first doses of the BNT162b2 mRNA and ChAdOx1 vaccines was associated with substantial reductions in the risk of hospital admission due to COVID-19 in Scotland. There remains the possibility that some of the observed effects might have been due to residual confounding.  Funding UK Research and Innovation (Medical Research Council), Research and Innovation Industrial Strategy Challenge Fund, Health Data Research UK.
dc.language.isoeng
dc.relation.ispartofThe Lanceten
dc.rightsCopyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.en
dc.subjectCOVID-19en
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subject3rd-DASen
dc.subject.lccRA0421en
dc.titleInterim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland : a national prospective cohort studyen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews.Sir James Mackenzie Institute for Early Diagnosisen
dc.identifier.doihttps://doi.org/10.1016/S0140-6736(21)00677-2
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0140673621006772?via%3Dihub#sec1en


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