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dc.contributor.authorReynolds, Paul Andrew
dc.date.accessioned2021-06-04T23:45:19Z
dc.date.available2021-06-04T23:45:19Z
dc.date.issued2020-06
dc.identifier.citationReynolds , P A 2020 , ' The mechanobiology of kidney podocytes in health and disease ' , Clinical Science , vol. 134 , no. 11 , pp. 1245–1253 . https://doi.org/10.1042/CS20190764en
dc.identifier.issn0143-5221
dc.identifier.otherPURE: 268098469
dc.identifier.otherPURE UUID: 9116c4fe-43c3-467a-9b84-e2f0789d5998
dc.identifier.otherWOS: 000538865300003
dc.identifier.otherScopus: 85086051059
dc.identifier.urihttps://hdl.handle.net/10023/23311
dc.descriptionFunding: UK Biotechnology and Biological Sciences Research Council (BB/P027148/1).en
dc.description.abstractChronic kidney disease (CKD) substantially reduces quality of life and leads to premature death for thousands of people each year. Dialysis and kidney organ transplants remain prevalent therapeutic avenues but carry significant medical, economic and social burden. Podocytes are responsible for blood filtration selectivity in the kidney, where they extend a network of foot processes (FPs) from their cell bodies which surround endothelial cells and interdigitate with those on neighbouring podocytes to form narrow slit diaphragms (SDs). During aging, some podocytes are lost naturally but accelerated podocyte loss is a hallmark of CKD. Insights into the origin of degenerative podocyte loss will help answer important questions about kidney function and lead to substantial health benefits. Here, approaches that uncover insights into podocyte mechanobiology are reviewed, both those that interrogate the biophysical properties of podocytes and how the external physical environment affects podocyte behaviour, and also those that interrogate the biophysical effects that podocytes exert on their surroundings.
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofClinical Scienceen
dc.rightsCopyright © 2020 the Author(s). Published by Portland Press Limited on behalf of the Biochemical Society. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1042/CS20190764en
dc.subjectBiophysicsen
dc.subjectMechanotransductionen
dc.subjectPodoctyesen
dc.subjectQC Physicsen
dc.subjectQH301 Biologyen
dc.subjectRC Internal medicineen
dc.subject.lccQCen
dc.subject.lccQH301en
dc.subject.lccRCen
dc.titleThe mechanobiology of kidney podocytes in health and diseaseen
dc.typeJournal itemen
dc.contributor.sponsorBBSRCen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.identifier.doihttps://doi.org/10.1042/CS20190764
dc.description.statusPeer revieweden
dc.date.embargoedUntil2021-06-05
dc.identifier.grantnumberBB/P027148/1en


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