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dc.contributor.authorMansley, Morag K.
dc.contributor.authorIvy, Jessica R.
dc.contributor.authorBailey, Matthew A.
dc.date.accessioned2021-05-24T15:30:05Z
dc.date.available2021-05-24T15:30:05Z
dc.date.issued2016-09
dc.identifier.citationMansley , M K , Ivy , J R & Bailey , M A 2016 , ' ISN Forefronts Symposium 2015 : the evolution of hypertension – old genes, new concepts ' , Kidney International Reports , vol. 1 , no. 3 , pp. 197-203 . https://doi.org/10.1016/j.ekir.2016.08.003en
dc.identifier.issn2468-0249
dc.identifier.otherPURE: 268444928
dc.identifier.otherPURE UUID: a6ab2216-aba9-4a37-9cea-bff0bd484fd4
dc.identifier.otherScopus: 84996538058
dc.identifier.urihttp://hdl.handle.net/10023/23243
dc.descriptionFunding: British Heart Foundation and Kidney Research UK.en
dc.description.abstractHypertension is known as the “silent killer,” driving the global public health burden of cardiovascular and renal disease. Blood pressure homeostasis is intimately associated with sodium balance and the distribution of sodium between fluid compartments and within tissues. On a population level, most societies consume 10 times more salt that the 0.5 g required by physiological need. This high salt intake is strongly linked to hypertension and to the World Health Organization targeting a ∼30% relative reduction in mean population salt intake to arrest the global mortality due to cardiovascular disease. But how does a habitually high-salt diet cause blood pressure to rise? In this focused review, we discuss 2 “evolutionary medicine” concepts, presented at the ISN Forefront Meeting “Immunomodulation of Cardio-renal Function.” We first examine how ancestral variants in genes that conferred a selection advantage during early human development are now maladaptive. We then discuss the conservation of “renal” sodium transport processes across multiple organ systems, including the brain. These systems influence sodium appetite and can exert an often-overlooked effect on long-term blood pressure control.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofKidney International Reportsen
dc.rightsCopyright © 2016 International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectBlood pressureen
dc.subjectEvolutionen
dc.subjectHypertensionen
dc.subjectInflammationen
dc.subjectKidneyen
dc.subjectPressure natriuresisen
dc.subjectSalten
dc.subjectQH301 Biologyen
dc.subjectQH426 Geneticsen
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectNephrologyen
dc.subjectOphthalmologyen
dc.subjectT-NDASen
dc.subject.lccQH301en
dc.subject.lccQH426en
dc.subject.lccRA0421en
dc.titleISN Forefronts Symposium 2015 : the evolution of hypertension – old genes, new conceptsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Cellular Medicine Divisionen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1016/j.ekir.2016.08.003
dc.description.statusPeer revieweden


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