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dc.contributor.authorHepburn, Matt
dc.contributor.authorFoo, Ken
dc.contributor.authorWijesinghe, Philip
dc.contributor.authorMunro, Peter
dc.contributor.authorChin, Lixin
dc.contributor.authorKennedy, Brendan
dc.identifier.citationHepburn , M , Foo , K , Wijesinghe , P , Munro , P , Chin , L & Kennedy , B 2021 , ' Speckle-dependent accuracy in phase-sensitive optical coherence tomography ' , Optics Express , vol. 29 , no. 11 , pp. 16950-16968 .
dc.identifier.otherPURE: 274343568
dc.identifier.otherPURE UUID: 9c105e28-d65f-4c07-b923-cb9aedb093bf
dc.identifier.otherORCID: /0000-0002-8378-7261/work/94669917
dc.identifier.otherWOS: 000654369300084
dc.identifier.otherScopus: 85106269864
dc.descriptionFunding: Australian Research Council; Department of Health, Australian Government; Cancer Council Western Australia; Oncores Medical; The William and Marlene Schrader Trust of the University of Western Australia; Royal Society.en
dc.description.abstractPhase-sensitive optical coherence tomography (OCT) is used to measure motion in a range of techniques, such as Doppler OCT and optical coherence elastography (OCE). In phase-sensitive OCT, motion is typically estimated using a model of the OCT signal derived from a single reflector. However, this approach is not representative of turbid samples, such as tissue, which exhibit speckle. In this study, for the first time, we demonstrate, through theory and experiment that speckle significantly lowers the accuracy of phase-sensitive OCT in a manner not accounted for by the OCT signal-to-noise ratio (SNR). We describe how the inaccuracy in speckle reduces phase difference sensitivity and introduce a new metric, speckle brightness, to quantify the amount of constructive interference at a given location in an OCT image. Experimental measurements show an almost three-fold degradation in sensitivity between regions of high and low speckle brightness at a constant OCT SNR. Finally, we apply these new results in compression OCE to demonstrate a ten-fold improvement in strain sensitivity, and a five-fold improvement in contrast-to-noise by incorporating independent speckle realizations. Our results show that speckle introduces a limit to the accuracy of phase-sensitive OCT and that speckle brightness should be considered to avoid erroneous interpretation of experimental data.
dc.relation.ispartofOptics Expressen
dc.rightsCopyright © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the final published version of the work, which was originally published at
dc.subjectQC Physicsen
dc.subjectQH301 Biologyen
dc.subjectR Medicineen
dc.titleSpeckle-dependent accuracy in phase-sensitive optical coherence tomographyen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.description.statusPeer revieweden

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