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dc.contributor.authorConti, Aldo Alberto
dc.contributor.authorTolomeo, Serenella
dc.contributor.authorSteele, Douglas
dc.contributor.authorBaldacchino, Alexander Mario
dc.identifier.citationConti , A A , Tolomeo , S , Steele , D & Baldacchino , A M 2020 , ' Severity of negative mood and anxiety symptoms occurring during acute abstinence from tobacco : a systematic review and meta-analysis ' , Neuroscience and Biobehavioral Reviews , vol. 115 , pp. 48-63 .
dc.identifier.otherPURE: 265545122
dc.identifier.otherPURE UUID: 396c24bd-02cb-4601-80f9-21a5df2ad311
dc.identifier.otherScopus: 85085746979
dc.identifier.otherWOS: 000579731200007
dc.description.abstractThis review was conducted with the following goals: To quantify the severity of mood and anxiety symptoms emerging during acute abstinence from tobacco (1). To explore sex differences related to the experience of specific symptoms (2). To investigate the early time course of symptoms (3). A meta-analysis was performed from 28 studies assessing mood and anxiety symptoms during the earliest phases of tobacco abstinence (up to 24 hrs post-quit) conducted from 1999 to 2019. Results revealed a significant (p < 0.0001) increase in ‘anxiety’, ‘anger/irritability’, ‘depressed mood /sadness’, and composite negative affect (‘NA’) in the 24 hours following smoking cessation. The largest effect size was detected for ‘anxiety’ (0.63). A qualitative analysis was performed to investigate sex differences and the time course of the specific symptoms. Results indicated that female smokers may experience worse mood symptoms compared to male smokers and that these symptoms may emerge within 3 hrs post-quit. Smoking cessation programs should implement sex-tailored interventions in order to improve their effectiveness, while future research should focus on alternative methods of nicotine administration.
dc.relation.ispartofNeuroscience and Biobehavioral Reviewsen
dc.rightsCopyright © 2020 Elsevier Ltd. All rights reserved. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at
dc.subjectAcute abstinenceen
dc.subjectNegative effecten
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleSeverity of negative mood and anxiety symptoms occurring during acute abstinence from tobacco : a systematic review and meta-analysisen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Centre for Minorities Research (CMR)en
dc.contributor.institutionUniversity of St Andrews.Population and Behavioural Science Divisionen
dc.description.statusPeer revieweden

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