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dc.contributor.authorFarrell, Karen
dc.contributor.authorTandan, Meera
dc.contributor.authorHernandez Santiago, Virginia
dc.contributor.authorGagyor, Ildiko
dc.contributor.authorBraend, Anja Maria
dc.contributor.authorSkow, Marius
dc.contributor.authorVik, Ingvild
dc.contributor.authorJansaaker, Filip
dc.contributor.authorHayward, Gail
dc.contributor.authorVellinga, Akke
dc.date.accessioned2021-05-06T16:30:11Z
dc.date.available2021-05-06T16:30:11Z
dc.date.issued2021-04
dc.identifier.citationFarrell , K , Tandan , M , Hernandez Santiago , V , Gagyor , I , Braend , A M , Skow , M , Vik , I , Jansaaker , F , Hayward , G & Vellinga , A 2021 , ' Treatment of uncomplicated UTI in males : a systematic review of the literature ' , BJGP Open , vol. 5 , no. 2 . https://doi.org/10.3399/bjgpopen20X101140en
dc.identifier.issn2398-3795
dc.identifier.otherPURE: 272337439
dc.identifier.otherPURE UUID: 70cf5252-92a2-43a2-b45e-94cb35b5562d
dc.identifier.otherORCID: /0000-0002-8544-1483/work/86987227
dc.identifier.otherScopus: 85106633977
dc.identifier.urihttp://hdl.handle.net/10023/23125
dc.description.abstractBackground Urinary tract infections (UTIs) affect around 20% of the male population in their lifetime. The incidence of UTIs in men in the community is 0.9–2.4 cases per 1000 aged <55 years and 7.7 per 1000 aged ≥85 years. Aim To evaluate the outcomes of randomised controlled trials (RCTs) comparing the effectiveness of different antimicrobial treatments and durations for uncomplicated UTIs in adult males in outpatient settings. Method A systematic literature review of RCTs of adult male patients with an uncomplicated UTI treated with oral antimicrobials in any outpatient setting. The outcomes were symptom resolution within 2 weeks of starting treatment, duration until symptom resolution, clinical cure, bacteriological cure, and frequency of adverse events. Results From the 1052 abstracts screened, three provided sufficient information on outcomes. One study compared trimethoprim-sulfamethoxazole for 14 days (21 males) with 42 days (21 males). Fluoroquinolones were compared in the two other RCTs: lomefloxacin (10 males) with norfloxacin (11 males), and ciprofloxacin for 7 days (19 males) and 14 days (19 males). Combining the results from the three RCTs shows that for 75% males with a UTI (76/101) bacteriological cure was reported at the end of the study. Of the 59 patients receiving a fluoroquinolone, 57 (97%) reported bacteriological and clinical cure within 2 weeks after treatment. Conclusion The evidence available is insufficient to make any recommendations in relation to type and duration of antimicrobial treatment for male UTIs. Sufficiently powered RCTs are needed to identify best treatment type and duration for male UTIs in primary care.
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofBJGP Openen
dc.rightsCopyright © 2020, The Authors. This article is Open Access: CC BY license (https://creativecommons.org/licenses/by/4.0/).en
dc.subjectMalesen
dc.subjectUrinary Tract Infectionsen
dc.subjectAntibiotic treatmenten
dc.subjectPrimary careen
dc.subjectRandomised clinical trialen
dc.subjectReviewen
dc.subjectRA Public aspects of medicineen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subject3rd-DASen
dc.subject.lccRAen
dc.subject.lccRMen
dc.titleTreatment of uncomplicated UTI in males : a systematic review of the literatureen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.3399/bjgpopen20X101140
dc.description.statusPeer revieweden


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