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dc.contributor.authorWilkinson, Gerald S.
dc.contributor.authorAdams, Danielle M.
dc.contributor.authorHaghani, Amin
dc.contributor.authorLu, Ake T.
dc.contributor.authorZoller, Joseph
dc.contributor.authorBreeze, Charles E.
dc.contributor.authorArnold, Bryan D.
dc.contributor.authorBall, Hope C.
dc.contributor.authorCarter, Gerald G.
dc.contributor.authorCooper, Lisa Noelle
dc.contributor.authorDechmann, Dina K. N.
dc.contributor.authorDevanna, Paolo
dc.contributor.authorFasel, Nicolas J.
dc.contributor.authorGalazyuk, Alexander V.
dc.contributor.authorGünther, Linus
dc.contributor.authorHurme, Edward
dc.contributor.authorJones, Gareth
dc.contributor.authorKnörnschild, Mirjam
dc.contributor.authorLattenkamp, Ella Z.
dc.contributor.authorLi, Caesar Z.
dc.contributor.authorMayer, Frieder
dc.contributor.authorReinhardt, Josephine A.
dc.contributor.authorMedellin, Rodrigo A.
dc.contributor.authorNagy, Martina
dc.contributor.authorPope, Brian
dc.contributor.authorPower, Megan L.
dc.contributor.authorRansome, Roger D.
dc.contributor.authorTeeling, Emma C.
dc.contributor.authorVernes, Sonja C.
dc.contributor.authorZamora-Mejías, Daniel
dc.contributor.authorZhang, Joshua
dc.contributor.authorFaure, Paul A.
dc.contributor.authorGreville, Lucas J.
dc.contributor.authorHorvath, Steve
dc.date.accessioned2021-03-17T12:30:02Z
dc.date.available2021-03-17T12:30:02Z
dc.date.issued2021-03-12
dc.identifier.citationWilkinson , G S , Adams , D M , Haghani , A , Lu , A T , Zoller , J , Breeze , C E , Arnold , B D , Ball , H C , Carter , G G , Cooper , L N , Dechmann , D K N , Devanna , P , Fasel , N J , Galazyuk , A V , Günther , L , Hurme , E , Jones , G , Knörnschild , M , Lattenkamp , E Z , Li , C Z , Mayer , F , Reinhardt , J A , Medellin , R A , Nagy , M , Pope , B , Power , M L , Ransome , R D , Teeling , E C , Vernes , S C , Zamora-Mejías , D , Zhang , J , Faure , P A , Greville , L J & Horvath , S 2021 , ' DNA methylation predicts age and provides insight into exceptional longevity of bats ' , Nature Communications , vol. 12 , 1615 . https://doi.org/10.1038/s41467-021-21900-2en
dc.identifier.issn2041-1723
dc.identifier.otherPURE: 273341919
dc.identifier.otherPURE UUID: 156a98c8-2457-408c-be6d-7611f1826ca9
dc.identifier.otherJisc: 5e8e3c6acb5b4f5aa4bd539cdba41e7e
dc.identifier.otherpublisher-id: s41467-021-21900-2
dc.identifier.othermanuscript: 21900
dc.identifier.otherORCID: /0000-0003-0305-4584/work/90952379
dc.identifier.otherScopus: 85102504493
dc.identifier.otherWOS: 000630419400006
dc.identifier.urihttp://hdl.handle.net/10023/21641
dc.descriptionThis work was supported by a Paul G. Allen Frontiers Group grant to S.H., the University of Maryland, College of Computer, Mathematical and Natural Sciences to G.S.W., an Irish Research Council Consolidator Laureate Award to E.C.T., a UKRI Future Leaders Fellowship (MR/T021985/1) to S.C.V. and a Discovery Grant from the Natural Sciences and Engineering Research Council (NSERC) of Canada to P.A.F. S.C.V. and P.D. were supported by a Max Planck Research Group awarded to S.C.V. by the Max Planck Gesellschaft, and S.C.V. and E.Z.L. were supported by a Human Frontiers Science Program Grant (RGP0058/2016) awarded to S.C.V. L.J.G. was supported by an NSERC PGS-D scholarship.en
dc.description.abstractExceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately predicts chronological age. Across species, longevity is negatively associated with the rate of DNAm change at age-associated sites. Furthermore, analysis of several bat genomes reveals that hypermethylated age- and longevity-associated sites are disproportionately located in promoter regions of key transcription factors (TF) and enriched for histone and chromatin features associated with transcriptional regulation. Predicted TF binding site motifs and enrichment analyses indicate that age-related methylation change is influenced by developmental processes, while longevity-related DNAm change is associated with innate immunity or tumorigenesis genes, suggesting that bat longevity results from augmented immune response and cancer suppression.
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.rightsCopyright © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectAgeingen
dc.subjectEpigenomicsen
dc.subjectMethylation analysisen
dc.subjectQH301 Biologyen
dc.subjectQH426 Geneticsen
dc.subjectQL Zoologyen
dc.subjectDASen
dc.subject.lccQH301en
dc.subject.lccQH426en
dc.subject.lccQLen
dc.titleDNA methylation predicts age and provides insight into exceptional longevity of batsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.St Andrews Bioinformatics Uniten
dc.identifier.doihttps://doi.org/10.1038/s41467-021-21900-2
dc.description.statusPeer revieweden


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