Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus
Abstract
The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts.
Citation
Feng , X , Bello , D & O'Hagan , D 2021 , ' Isolation of 5′- O -sulfamyladenosine and related 3′- O -β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus ' , RSC Advances , vol. 11 , no. 10 , pp. 5291-5294 . https://doi.org/10.1039/D1RA00235J
Publication
RSC Advances
Status
Peer reviewed
ISSN
2046-2069Type
Journal article
Description
Funding: We thank EPSRC (EP/R013799/1) for a grant (DB) and the University of St Andrews for a Studentship (XF).Collections
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