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dc.contributor.authorLiu, Honglei
dc.contributor.authorSlawin, Alexandra M. M.
dc.contributor.authorSmith, Andrew D.
dc.date.accessioned2021-02-06T00:38:13Z
dc.date.available2021-02-06T00:38:13Z
dc.date.issued2020-02-06
dc.identifier.citationLiu , H , Slawin , A M M & Smith , A D 2020 , ' Isothiourea-catalyzed enantioselective synthesis of tetrahydro-α-carbolinones ' , Organic Letters , vol. Articles ASAP . https://doi.org/10.1021/acs.orglett.9b04615en
dc.identifier.issn1523-7060
dc.identifier.otherPURE: 266061894
dc.identifier.otherPURE UUID: 31528d11-8115-4fcd-afec-f122f92992b4
dc.identifier.otherORCID: /0000-0002-2104-7313/work/69029069
dc.identifier.otherORCID: /0000-0002-9527-6418/work/69029103
dc.identifier.otherScopus: 85079611795
dc.identifier.otherWOS: 000516667200016
dc.identifier.urihttps://hdl.handle.net/10023/21383
dc.descriptionThe research leading to these results has received funding from the Royal Society (Newton Fellowship Programme, H. L.). A.D.S. thanks the Royal Society for a Wolfson Research Merit Award.en
dc.description.abstractAn isothiourea-catalyzed enantioselective annulation protocol using indolin-2-imines with a series of α,β-unsaturated p-nitrophenyl esters for the synthesis of tetrahydro-α-carbolinones was developed. Using 5 mol % of the isothiourea HyperBTM as the Lewis base catalyst, this process allows the enantioselective preparation of a range of C(4)-substituted tetrahydro-α-carbolinones in good to excellent yield and with high enantioselectivity (20 examples, 32–99% yield and up to 99:1 er).
dc.language.isoeng
dc.relation.ispartofOrganic Lettersen
dc.rightsCopyright © 2020 American Chemical Society. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1021/acs.orglett.9b04615en
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleIsothiourea-catalyzed enantioselective synthesis of tetrahydro-α-carbolinonesen
dc.typeJournal articleen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.sponsorThe Royal Societyen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1021/acs.orglett.9b04615
dc.description.statusPeer revieweden
dc.date.embargoedUntil2021-02-06
dc.identifier.grantnumberWM140071en
dc.identifier.grantnumberNF170330en


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