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Isothiourea-catalyzed enantioselective synthesis of tetrahydro-α-carbolinones
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dc.contributor.author | Liu, Honglei | |
dc.contributor.author | Slawin, Alexandra M. M. | |
dc.contributor.author | Smith, Andrew D. | |
dc.date.accessioned | 2021-02-06T00:38:13Z | |
dc.date.available | 2021-02-06T00:38:13Z | |
dc.date.issued | 2020-02-06 | |
dc.identifier | 266061894 | |
dc.identifier | 31528d11-8115-4fcd-afec-f122f92992b4 | |
dc.identifier | 85079611795 | |
dc.identifier | 000516667200016 | |
dc.identifier.citation | Liu , H , Slawin , A M M & Smith , A D 2020 , ' Isothiourea-catalyzed enantioselective synthesis of tetrahydro-α-carbolinones ' , Organic Letters , vol. Articles ASAP . https://doi.org/10.1021/acs.orglett.9b04615 | en |
dc.identifier.issn | 1523-7060 | |
dc.identifier.other | ORCID: /0000-0002-2104-7313/work/69029069 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/69029103 | |
dc.identifier.uri | https://hdl.handle.net/10023/21383 | |
dc.description | The research leading to these results has received funding from the Royal Society (Newton Fellowship Programme, H. L.). A.D.S. thanks the Royal Society for a Wolfson Research Merit Award. | en |
dc.description.abstract | An isothiourea-catalyzed enantioselective annulation protocol using indolin-2-imines with a series of α,β-unsaturated p-nitrophenyl esters for the synthesis of tetrahydro-α-carbolinones was developed. Using 5 mol % of the isothiourea HyperBTM as the Lewis base catalyst, this process allows the enantioselective preparation of a range of C(4)-substituted tetrahydro-α-carbolinones in good to excellent yield and with high enantioselectivity (20 examples, 32–99% yield and up to 99:1 er). | |
dc.format.extent | 738060 | |
dc.language.iso | eng | |
dc.relation.ispartof | Organic Letters | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject.lcc | QD | en |
dc.title | Isothiourea-catalyzed enantioselective synthesis of tetrahydro-α-carbolinones | en |
dc.type | Journal article | en |
dc.contributor.sponsor | The Royal Society | en |
dc.contributor.sponsor | The Royal Society | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1021/acs.orglett.9b04615 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2021-02-06 | |
dc.identifier.grantnumber | WM140071 | en |
dc.identifier.grantnumber | NF170330 | en |
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