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dc.contributor.authorLiu, Honglei
dc.contributor.authorSlawin, Alexandra M. M.
dc.contributor.authorSmith, Andrew D.
dc.date.accessioned2021-02-06T00:38:13Z
dc.date.available2021-02-06T00:38:13Z
dc.date.issued2020-02-06
dc.identifier266061894
dc.identifier31528d11-8115-4fcd-afec-f122f92992b4
dc.identifier85079611795
dc.identifier000516667200016
dc.identifier.citationLiu , H , Slawin , A M M & Smith , A D 2020 , ' Isothiourea-catalyzed enantioselective synthesis of tetrahydro-α-carbolinones ' , Organic Letters , vol. Articles ASAP . https://doi.org/10.1021/acs.orglett.9b04615en
dc.identifier.issn1523-7060
dc.identifier.otherORCID: /0000-0002-2104-7313/work/69029069
dc.identifier.otherORCID: /0000-0002-9527-6418/work/69029103
dc.identifier.urihttps://hdl.handle.net/10023/21383
dc.descriptionThe research leading to these results has received funding from the Royal Society (Newton Fellowship Programme, H. L.). A.D.S. thanks the Royal Society for a Wolfson Research Merit Award.en
dc.description.abstractAn isothiourea-catalyzed enantioselective annulation protocol using indolin-2-imines with a series of α,β-unsaturated p-nitrophenyl esters for the synthesis of tetrahydro-α-carbolinones was developed. Using 5 mol % of the isothiourea HyperBTM as the Lewis base catalyst, this process allows the enantioselective preparation of a range of C(4)-substituted tetrahydro-α-carbolinones in good to excellent yield and with high enantioselectivity (20 examples, 32–99% yield and up to 99:1 er).
dc.format.extent738060
dc.language.isoeng
dc.relation.ispartofOrganic Lettersen
dc.subjectQD Chemistryen
dc.subjectDASen
dc.subject.lccQDen
dc.titleIsothiourea-catalyzed enantioselective synthesis of tetrahydro-α-carbolinonesen
dc.typeJournal articleen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doi10.1021/acs.orglett.9b04615
dc.description.statusPeer revieweden
dc.date.embargoedUntil2021-02-06
dc.identifier.grantnumberWM140071en
dc.identifier.grantnumberNF170330en


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