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Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
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dc.contributor.author | Demontis, Ditte | |
dc.contributor.author | Walters, Raymond K. | |
dc.contributor.author | Rajagopal, Veera M. | |
dc.contributor.author | Waldman, Irwin D. | |
dc.contributor.author | Grove, Jakob | |
dc.contributor.author | Als, Thomas D. | |
dc.contributor.author | Dalsgaard, Søren | |
dc.contributor.author | Ribasas, Marta | |
dc.contributor.author | Bybjerg-Grauholm, Jonas | |
dc.contributor.author | Bækvad-Hansen, Maria | |
dc.contributor.author | Werge, Thomas | |
dc.contributor.author | Nordentoft, Merete | |
dc.contributor.author | Mors, Ole | |
dc.contributor.author | Mortensen, Preben Bo | |
dc.contributor.author | (PGC), ADHD Working Group of the Psychiatric Genomics Consortium | |
dc.contributor.author | Andreassen, Ole A. | |
dc.contributor.author | Arranz, Maria Jesús | |
dc.contributor.author | Banaschewski, Tobias | |
dc.contributor.author | Bau, Claiton | |
dc.contributor.author | Bellgrove, Mark | |
dc.contributor.author | Biederman, Joseph | |
dc.contributor.author | Brikell, Isabell | |
dc.contributor.author | Buitelaar, Jan K. | |
dc.contributor.author | Burton, Christie L. | |
dc.contributor.author | Casas, Miguel | |
dc.contributor.author | Crosbie, Jennifer | |
dc.contributor.author | Doyle, Alysa E. | |
dc.contributor.author | Ebstein, Richard P. | |
dc.contributor.author | Elia, Josephine | |
dc.contributor.author | Elizabeth, Corfield C. | |
dc.contributor.author | Grevet, Eugenio | |
dc.contributor.author | Grizenko, Natalie | |
dc.contributor.author | Havdahl, Alexandra | |
dc.contributor.author | Hawi, Ziarih | |
dc.contributor.author | Hebebrand, Johannes | |
dc.contributor.author | Hervas, Amaia | |
dc.contributor.author | Hohmann, Sarah | |
dc.contributor.author | Haavik, Jan | |
dc.contributor.author | Joober, Ridha | |
dc.contributor.author | Kent, Lindsey | |
dc.contributor.author | Kuntsi, Jonna | |
dc.contributor.author | Langley, Kate | |
dc.contributor.author | Larsson, Henrik | |
dc.contributor.author | Lesch, Klaus-Peter | |
dc.contributor.author | Leung, Patrick W. L. | |
dc.contributor.author | Liao, Calwing | |
dc.contributor.author | Loo, Sandra K. | |
dc.contributor.author | Martin, Joanna | |
dc.contributor.author | Martin, Nicholas G. | |
dc.contributor.author | Medland, Sarah E. | |
dc.contributor.author | Miranda, Ana | |
dc.contributor.author | Mota, Nina Roth | |
dc.contributor.author | Oades, Robert D. | |
dc.contributor.author | Ramos-Quiroga, Josep Antoni | |
dc.contributor.author | Reif, Andreas | |
dc.contributor.author | Rietschel, Marcella | |
dc.contributor.author | Roeyers, Herbert | |
dc.contributor.author | Rohde, Luis Augusto | |
dc.contributor.author | Rothenberger, Aribert | |
dc.contributor.author | Rovira, Paula | |
dc.contributor.author | Sánchez-Mora, Cristina | |
dc.contributor.author | Schachar, Russell James | |
dc.contributor.author | Sengupta, Sarojini | |
dc.contributor.author | Artigas, Maria Soler | |
dc.contributor.author | Steinhausen, Hans-Christoph | |
dc.contributor.author | Thapar, Anita | |
dc.contributor.author | Witt, Stephanie H. | |
dc.contributor.author | Yang, Li | |
dc.contributor.author | Zayats, Tetyana | |
dc.contributor.author | Zhang-James, Yanli | |
dc.contributor.author | Cormand, Bru | |
dc.contributor.author | Hougaard, David M. | |
dc.contributor.author | Neale, Benjamin M. | |
dc.contributor.author | Franke, Barbara | |
dc.contributor.author | Faraone, Stephen V. | |
dc.contributor.author | Børglum, Anders D. | |
dc.date.accessioned | 2021-02-04T11:30:11Z | |
dc.date.available | 2021-02-04T11:30:11Z | |
dc.date.issued | 2021-01-25 | |
dc.identifier | 272706531 | |
dc.identifier | fb87a9c1-ecfa-443e-a448-3bd3a5475461 | |
dc.identifier | 85099802296 | |
dc.identifier.citation | Demontis , D , Walters , R K , Rajagopal , V M , Waldman , I D , Grove , J , Als , T D , Dalsgaard , S , Ribasas , M , Bybjerg-Grauholm , J , Bækvad-Hansen , M , Werge , T , Nordentoft , M , Mors , O , Mortensen , P B , (PGC) , ADHD W G O T P G C , Andreassen , O A , Arranz , M J , Banaschewski , T , Bau , C , Bellgrove , M , Biederman , J , Brikell , I , Buitelaar , J K , Burton , C L , Casas , M , Crosbie , J , Doyle , A E , Ebstein , R P , Elia , J , Elizabeth , C C , Grevet , E , Grizenko , N , Havdahl , A , Hawi , Z , Hebebrand , J , Hervas , A , Hohmann , S , Haavik , J , Joober , R , Kent , L , Kuntsi , J , Langley , K , Larsson , H , Lesch , K-P , Leung , P W L , Liao , C , Loo , S K , Martin , J , Martin , N G , Medland , S E , Miranda , A , Mota , N R , Oades , R D , Ramos-Quiroga , J A , Reif , A , Rietschel , M , Roeyers , H , Rohde , L A , Rothenberger , A , Rovira , P , Sánchez-Mora , C , Schachar , R J , Sengupta , S , Artigas , M S , Steinhausen , H-C , Thapar , A , Witt , S H , Yang , L , Zayats , T , Zhang-James , Y , Cormand , B , Hougaard , D M , Neale , B M , Franke , B , Faraone , S V & Børglum , A D 2021 , ' Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder ' , Nature Communications , vol. 12 , no. 1 , 576 . https://doi.org/10.1038/s41467-020-20443-2 | en |
dc.identifier.issn | 2041-1723 | |
dc.identifier.other | RIS: urn:19D1C98E5BBBA632BDCF861FEAAF769F | |
dc.identifier.other | RIS: Demontis2021 | |
dc.identifier.other | ORCID: /0000-0002-5315-3399/work/88267105 | |
dc.identifier.uri | https://hdl.handle.net/10023/21375 | |
dc.description.abstract | Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior. | |
dc.format.extent | 12 | |
dc.format.extent | 1067954 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature Communications | en |
dc.subject | ADHD | en |
dc.subject | Genome-wide association studies | en |
dc.subject | QH426 Genetics | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject | DAS | en |
dc.subject.lcc | QH426 | en |
dc.subject.lcc | RC0321 | en |
dc.title | Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. Cellular Medicine Division | en |
dc.identifier.doi | https://doi.org/10.1038/s41467-020-20443-2 | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | https://www.nature.com/articles/s41467-021-21566-w | en |
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