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dc.contributor.authorWatson, David
dc.contributor.authorPomeroy, Patrick
dc.contributor.authorKennedy, Malcolm
dc.date.accessioned2021-01-11T10:30:03Z
dc.date.available2021-01-11T10:30:03Z
dc.date.issued2021-01-11
dc.identifier.citationWatson , D , Pomeroy , P & Kennedy , M 2021 , ' Atlantic grey seal milk shows continuous changes in key metabolites and indicators of metabolic transition in pups from birth to weaning ' , Frontiers in Marine Science , vol. 7 , 596904 . https://doi.org/10.3389/fmars.2020.596904en
dc.identifier.issn2296-7745
dc.identifier.otherPURE: 269567460
dc.identifier.otherPURE UUID: 28904143-263a-49a6-a64c-2124880d099e
dc.identifier.otherORCID: /0000-0003-1603-5630/work/86986532
dc.identifier.otherScopus: 85099872134
dc.identifier.otherWOS: 000611878500001
dc.identifier.urihttp://hdl.handle.net/10023/21255
dc.descriptionThe work was funded from core support given to the Sea Mammal Research Unit, Scottish Oceans Institute, from the National Environmental Research Council (United Kingdom), and separately by the Universities of Glasgow and Strathclyde. The funding of mass spectrometry equipment for metabolomics was provided by the Scottish Life Sciences Alliance.en
dc.description.abstractMothers of the Atlantic grey seal, Halichoerus grypus, lactate for about 20 days, during which they do not feed and may have no access to water. Following weaning, they depart to sea leaving their pups unattended and unfed for up to another 40 days. We are interested in how this lactation strategy supports the pups’ rapid growth and development while also preparing them for their long fast before independently going to sea. We report a broad spectrum metabolomic analysis of whole milks of these seals that reveals continuous changes in key metabolites from birth to weaning. Certain components exhibit abbreviated appearances at the onset of lactation, followed by continuous rises or falls in others until weaning. Riboflavin/Vitamin B2, hormone-related sterol sulfates, lactose, and complex oligosaccharides all appear in milk briefly after birth then disappear. Lipids associated with cellular signaling and brain development occur at highest levels shortly after birth, then diminish. In contrast, other lipids and Vitamin B6/pyridoxine steadily increase as weaning approaches. Overall, these findings may indicate an early transition from carbohydrate to fat-based energy metabolism and establishment of gut microbiomes in pups, followed by provisioning for post-weaning development and fasting.
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofFrontiers in Marine Scienceen
dc.rightsCopyright © 2021 Watson, Pomeroy and Kennedy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectAtlantic grey sealen
dc.subjectHalichoerus grypusen
dc.subjectMilken
dc.subjectVitaminsen
dc.subjectLactoseen
dc.subjectOligosaccharidesen
dc.subjectSterolsen
dc.subjectMetabolomeen
dc.subjectQH301 Biologyen
dc.subjectDASen
dc.subject.lccQH301en
dc.titleAtlantic grey seal milk shows continuous changes in key metabolites and indicators of metabolic transition in pups from birth to weaningen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Sea Mammal Research Uniten
dc.contributor.institutionUniversity of St Andrews.Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews.Centre for Research into Ecological & Environmental Modellingen
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.identifier.doihttps://doi.org/10.3389/fmars.2020.596904
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fmars.2020.596904/fullen


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