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Genetic lesions of type I interferon signalling in human antiviral immunity
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dc.contributor.author | Duncan, Christopher J.A. | |
dc.contributor.author | Randall, Richard E. | |
dc.contributor.author | Hambleton, Sophie | |
dc.date.accessioned | 2021-01-07T13:30:08Z | |
dc.date.available | 2021-01-07T13:30:08Z | |
dc.date.issued | 2021-01 | |
dc.identifier.citation | Duncan , C J A , Randall , R E & Hambleton , S 2021 , ' Genetic lesions of type I interferon signalling in human antiviral immunity ' , Trends in Genetics , vol. 37 , no. 1 , pp. 46-58 . https://doi.org/10.1016/j.tig.2020.08.017 | en |
dc.identifier.issn | 0168-9525 | |
dc.identifier.other | PURE: 270619365 | |
dc.identifier.other | PURE UUID: ed6cdcb4-317a-487e-a196-bc64936f417f | |
dc.identifier.other | RIS: urn:40FBBFE187475FD6BEA8BDDC2680C67D | |
dc.identifier.other | Scopus: 85091614750 | |
dc.identifier.other | WOS: 000604333900007 | |
dc.identifier.uri | https://hdl.handle.net/10023/21238 | |
dc.description | Funding was provided by the Wellcome Trust [211153/Z/18/Z (C.J.A.D.), 207556/Z/17/Z (S.H.), 101788/Z/13/Z (R.E.R.)], Sir Jules Thorn Trust [12/JTA (S.H.)], and the British Medical Association (C.J.A.D). | en |
dc.description.abstract | The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from studies on animal models and cell lines. Virtually all pathogenic viruses have evolved countermeasures to IFN-I restriction, and genetic loss of viral IFN-I antagonists leads to virus attenuation. But just how important is IFN-I to antiviral defence in humans? The recent discovery of genetic defects of IFN-I signalling illuminates this and other questions of IFN biology, including the role of the mucosa-restricted type III IFNs (IFN-III), informing our understanding of the place of the IFN system within the concerted antiviral response. Here we review monogenic lesions of IFN-I signalling pathways and summarise the organising principles which emerge. | |
dc.format.extent | 13 | |
dc.language.iso | eng | |
dc.relation.ispartof | Trends in Genetics | en |
dc.rights | Copyright © 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.subject | Type I interferons | en |
dc.subject | Interferon-stimulated genes | en |
dc.subject | JAK–STAT signalling | en |
dc.subject | IFNAR | en |
dc.subject | Inborn errors of immunity | en |
dc.subject | Antiviral immunity | en |
dc.subject | QH301 Biology | en |
dc.subject | QH426 Genetics | en |
dc.subject | QR355 Virology | en |
dc.subject.lcc | QH301 | en |
dc.subject.lcc | QH426 | en |
dc.subject.lcc | QR355 | en |
dc.title | Genetic lesions of type I interferon signalling in human antiviral immunity | en |
dc.type | Journal item | en |
dc.contributor.sponsor | The Wellcome Trust | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1016/j.tig.2020.08.017 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | 101788/Z/13/Z | en |
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