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dc.contributor.authorVornholt, Simon M
dc.contributor.authorDuncan, Morven J
dc.contributor.authorWarrender, Stewart J
dc.contributor.authorSemino, Rocio
dc.contributor.authorRamsahye, Naseem A
dc.contributor.authorMaurin, Guillaume
dc.contributor.authorSmith, Martin W
dc.contributor.authorTan, Jin-Chong
dc.contributor.authorMiller, David N
dc.contributor.authorMorris, Russell E
dc.identifier.citationVornholt , S M , Duncan , M J , Warrender , S J , Semino , R , Ramsahye , N A , Maurin , G , Smith , M W , Tan , J-C , Miller , D N & Morris , R E 2020 , ' Multifaceted study of the interactions between CPO-27-Ni and polyurethane and their impact on nitric oxide release performance ' , ACS Applied Materials & Interfaces , vol. 12 , no. 52 , pp. 58263-58276 .
dc.identifier.otherPURE: 271749233
dc.identifier.otherPURE UUID: 1e6b7475-47a5-45a1-bae1-81a2efe384d9
dc.identifier.otherPubMed: 33325239
dc.identifier.otherORCID: /0000-0001-7809-0315/work/85566215
dc.identifier.otherWOS: 000605187100056
dc.identifier.otherScopus: 85098793755
dc.descriptionS.M.V. would like to thank the EPSRC for funding opportunities under grant agreement EP/K005499/1. S.M.V. and D.N.M. would further like to acknowledge the EPSRC Capital for Great Technologies grant (EP/L017008/1) and the EPSRC Strategic Equipment Resource grant (EP/R023751) for funding and supporting electron microscopy facilities at the University of St Andrews. M.J.D. and S.J.W. would like to acknowledge the ProDIA project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 685727.en
dc.description.abstractA multifaceted study involving focused ion beam scanning electron microscopy techniques, mechanical analysis, water adsorption measurements, and molecular simulations is employed to rationalize the nitric oxide release performance of polyurethane films containing 5, 10, 20, and 40 wt % of the metal-organic framework (MOF) CPO-27-Ni. The polymer and the MOF are first demonstrated to exhibit excellent compatibility. This is reflected in the even distribution and encapsulation of large wt % MOF loadings throughout the full thickness of the films and by the rather minimal influence of the MOF on the mechanical properties of the polymer at low wt %. The NO release efficiency of the MOF is attenuated by the polymer and found to depend on wt % of MOF loading. The formation of a fully connected network of MOF agglomerates within the films at higher wt % is proposed to contribute to a more complex guest transport in these formulations, resulting in a reduction of NO release efficiency and film ductility. An optimum MOF loading of 10 wt % is identified for maximizing NO release without adversely impacting the polymer properties. Bactericidal efficacy of released NO from the films is demonstrated against Pseudomonas aeruginosa, with a >8 log10 reduction in cell density observed after a contact period of 24 h.
dc.relation.ispartofACS Applied Materials & Interfacesen
dc.rightsCopyright © 2020 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.en
dc.subjectOrganic polymersen
dc.subjectMetal-organic frameworksen
dc.subjectMixed-matrix membranesen
dc.subjectComposite materialsen
dc.subjectNitric oxideen
dc.subjectMedical applicationsen
dc.subjectQD Chemistryen
dc.titleMultifaceted study of the interactions between CPO-27-Ni and polyurethane and their impact on nitric oxide release performanceen
dc.typeJournal articleen
dc.contributor.sponsorEuropean Research Councilen
dc.contributor.sponsorEuropean Commissionen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.description.statusPeer revieweden

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