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dc.contributor.authorClarkson, Jan E
dc.contributor.authorPitts, Nigel B
dc.contributor.authorGoulao, Beatriz
dc.contributor.authorBoyers, Dwayne
dc.contributor.authorRamsay, Craig R
dc.contributor.authorFloate, Ruth
dc.contributor.authorBraid, Hazel J
dc.contributor.authorFee, Patrick A
dc.contributor.authorOrd, Fiona S
dc.contributor.authorWorthington, Helen V
dc.contributor.authorvan der Pol, Marjon
dc.contributor.authorYoung, Linda
dc.contributor.authorFreeman, Ruth
dc.contributor.authorGouick, Jill
dc.contributor.authorHumphris, Gerald M
dc.contributor.authorMitchell, Fiona E
dc.contributor.authorMcDonald, Alison M
dc.contributor.authorNorrie, John DT
dc.contributor.authorSim, Kirsty
dc.contributor.authorDouglas, Gail
dc.contributor.authorRicketts, David
dc.date.accessioned2020-12-07T15:58:48Z
dc.date.available2020-12-07T15:58:48Z
dc.date.issued2020-11-20
dc.identifier.citationClarkson , J E , Pitts , N B , Goulao , B , Boyers , D , Ramsay , C R , Floate , R , Braid , H J , Fee , P A , Ord , F S , Worthington , H V , van der Pol , M , Young , L , Freeman , R , Gouick , J , Humphris , G M , Mitchell , F E , McDonald , A M , Norrie , J DT , Sim , K , Douglas , G & Ricketts , D 2020 , ' Risk-based, 6-monthly and 24-monthly dental check-ups for adults : the INTERVAL three-arm RCT ' , Health Technology Assessment , vol. 24 , no. 60 , pp. 1-138 . https://doi.org/10.3310/hta24600en
dc.identifier.issn1366-5278
dc.identifier.otherPURE: 271422870
dc.identifier.otherPURE UUID: 1cb9c586-bfb8-4a51-8d8f-9a24fd70b2b0
dc.identifier.otherPubMed: 33215986
dc.identifier.otherORCID: /0000-0002-4601-8834/work/84314991
dc.identifier.otherWOS: 000591733700001
dc.identifier.otherScopus: 85096814174
dc.identifier.urihttp://hdl.handle.net/10023/21104
dc.descriptionFunding: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme [project numbers 06/35/05 (Phase I) and 06/35/99 (Phase II).en
dc.description.abstractBackground: Traditionally, patients are encouraged to attend dental recall appointments at regular 6-month intervals, irrespective of their risk of developing dental disease. Stakeholders lack evidence of the relative effectiveness and cost-effectiveness of different recall strategies and the optimal recall interval for maintenance of oral health. Objectives: To test effectiveness and assess the cost-benefit of different dental recall intervals over a 4-year period. Design: Multicentre, parallel-group, randomised controlled trial with blinded clinical outcome assessment at 4 years and a within-trial cost-benefit analysis. NHS and participant perspective costs were combined with benefits estimated from a general population discrete choice experiment. A two-stratum trial design was used, with participants randomised to the 24-month interval if the recruiting dentist considered them clinically suitable. Participants ineligible for 24-month recall were randomised to a risk-based or 6-month recall interval. Setting: UK primary care dental practices. Participants: Adult, dentate, NHS patients who had visited their dentist in the previous 2 years. Interventions: Participants were randomised to attend for a dental check-up at one of three dental recall intervals: 6-month, risk-based or 24-month recall. Main outcomes: Clinical - gingival bleeding on probing; patient - oral health-related quality of life; economic - three analysis frameworks: (1) incremental cost per quality-adjusted life-year gained, (2) incremental net (societal) benefit and (3) incremental net (dental health) benefit. Results: A total of 2372 participants were recruited from 51 dental practices; 648 participants were eligible for the 24-month recall stratum and 1724 participants were ineligible. There was no evidence of a significant difference in the mean percentage of sites with gingival bleeding between intervention arms in any comparison. For the eligible for 24-month recall stratum: the 24-month (n = 138) versus 6-month group (n = 135) had an adjusted mean difference of -0.91 (95% confidence interval -5.02 to 3.20); the risk-based (n = 143) versus 6-month group had an adjusted mean difference of -0.98 (95% confidence interval -5.05 to 3.09); the 24-month versus risk-based group had an adjusted mean difference of 0.07 (95% confidence interval -3.99 to 4.12). For the overall sample, the risk-based (n = 749) versus 6-month (n = 737) adjusted mean difference was 0.78 (95% confidence interval -1.17 to 2.72). There was no evidence of a difference in oral health-related quality of life between intervention arms in any comparison. For the economic evaluation, under framework 1 (cost per quality-adjusted life-year) the results were highly uncertain, and it was not possible to identify the optimal recall strategy. Under framework 2 (net societal benefit), 6-month recalls were the most efficient strategy with a probability of positive net benefit ranging from 78% to 100% across the eligible and combined strata, with findings driven by the high value placed on more frequent recall services in the discrete choice experiment. Under framework 3 (net dental health benefit), 24-month recalls were the most likely strategy to deliver positive net (dental health) benefit among those eligible for 24-month recall, with a probability of positive net benefit ranging from 65% to 99%. For the combined group, the optimal strategy was less clear. Risk-based recalls were more likely to be the most efficient recall strategy in scenarios where the costing perspective was widened to include participant-incurred costs, and in the Scottish subgroup. Limitations: Information regarding factors considered by dentists to inform the risk-based interval and the interaction with patients to determine risk and agree the interval were not collected. Conclusions: Over a 4-year period, we found no evidence of a difference in oral health for participants allocated to a 6-month or a risk-based recall interval, nor between a 24-month, 6-month or risk-based recall interval for participants eligible for a 24-month recall. However, people greatly value and are willing to pay for frequent dental check-ups; therefore, the most efficient recall strategy depends on the scope of the cost and benefit valuation that decision-makers wish to consider. Future work: Assessment of the impact of risk assessment tools in informing risk-based interval decision-making and techniques for communicating a variable recall interval to patients.
dc.format.extent138
dc.language.isoeng
dc.relation.ispartofHealth Technology Assessmenten
dc.rightsCopyright © Queen’s Printer and Controller of HMSO 2020. This work was produced by Clarkson et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.en
dc.subjectRK Dentistryen
dc.subjectDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject~DC~en
dc.subject.lccRKen
dc.titleRisk-based, 6-monthly and 24-monthly dental check-ups for adults : the INTERVAL three-arm RCTen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews.WHO Collaborating Centre for International Child & Adolescent Health Policyen
dc.contributor.institutionUniversity of St Andrews.St Andrews Sustainability Instituteen
dc.contributor.institutionUniversity of St Andrews.Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews.Health Psychologyen
dc.identifier.doihttps://doi.org/10.3310/hta24600
dc.description.statusPeer revieweden


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