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dc.contributor.authorStock, Sarah
dc.contributor.authorMcAllister, David
dc.contributor.authorVasileiou, Eleftheria
dc.contributor.authorSimpson, Colin R
dc.contributor.authorStagg, Helen R
dc.contributor.authorAgrawal, Utkarsh
dc.contributor.authorMcCowan, Colin
dc.contributor.authorHopkins, Leanne
dc.contributor.authorDonaghy, Jack
dc.contributor.authorRitchie, Lewis
dc.contributor.authorRobertson, Chris
dc.contributor.authorSheikh, Aziz
dc.contributor.authorWood, Rachael
dc.identifier.citationStock , S , McAllister , D , Vasileiou , E , Simpson , C R , Stagg , H R , Agrawal , U , McCowan , C , Hopkins , L , Donaghy , J , Ritchie , L , Robertson , C , Sheikh , A & Wood , R 2020 , ' COVID-19 in Pregnancy in Scotland (COPS) : protocol for an observational study using linked Scottish national data ' , BMJ Open , vol. 10 , no. 11 , e042813 .
dc.identifier.otherPURE: 270908499
dc.identifier.otherPURE UUID: 3ec5b37b-3995-48b5-95fe-b57509adaf5e
dc.identifier.otherORCID: /0000-0002-9466-833X/work/84753413
dc.identifier.otherScopus: 85096947330
dc.identifier.otherWOS: 000596216900024
dc.descriptionFunding: EAVE II funded by the Medical Research Council (MR/R008345/1) with the support of BREATHE - The Health Data Research Hub for Respiratory Health [MC_PC_19004], which is funded through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. Additional support has been provided through the Scottish Government DG Health and Social Care. COPS receive additional funding from Tommy’s charity (1060508; SC039280). SJS is supported by Wellcome Trust (209560/Z/17/Z).en
dc.description.abstractIntroduction The effects of SARS-CoV-2 in pregnancy are not fully delineated. We will describe the incidence of COVID-19 in pregnancy at population level in Scotland, in a prospective cohort study using linked data. We will determine associations between COVID-19 and adverse pregnancy, neonatal and maternal outcomes and the proportion of confirmed cases of SARS-CoV-2 infection in neonates associated with maternal COVID-19. Methods and analysis Prospective cohort study using national linked data sets. We will include all women in Scotland, UK, who were pregnant on or became pregnant after, 1 March 2020 (the date of the first confirmed case of SARS-CoV-2 infection in Scotland) and all births in Scotland from 1 March 2020 onwards. Individual-level data will be extracted from data sets containing details of all livebirths, stillbirth, terminations of pregnancy and miscarriages and ectopic pregnancies treated in hospital or attending general practice. Records will be linked within the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) platform, which includes primary care records, virology and serology results and details of COVID-19 Community Hubs and Assessment Centre contacts and deaths. We will perform analyses using definitions for confirmed, probable and possible COVID-19 and report serology results (where available). Outcomes will include congenital anomaly, miscarriage, stillbirth, termination of pregnancy, preterm birth, neonatal infection, severe maternal disease and maternal deaths. We will perform descriptive analyses and appropriate modelling, adjusting for demographic and pregnancy characteristics and the presence of comorbidities. The cohort will provide a platform for future studies of the effectiveness and safety of therapeutic interventions and immunisations for COVID-19 and their effects on childhood and developmental outcomes. Ethics and dissemination COVID-19 in Pregnancy in Scotland is a substudy of EAVE II(, which has approval from the National Research Ethics Service Committee. Findings will be reported to Scottish Government, Public Health Scotland and published in peer-reviewed journals.
dc.relation.ispartofBMJ Openen
dc.rightsCopyright © Author(s) (or their employer(s)) 2020. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See:
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subjectRG Gynecology and obstetricsen
dc.titleCOVID-19 in Pregnancy in Scotland (COPS) : protocol for an observational study using linked Scottish national dataen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews.Population and Behavioural Science Divisionen
dc.description.statusPeer revieweden

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