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dc.contributor.authorHachoumi, Lamia
dc.contributor.authorSillar, Keith Thomas
dc.date.accessioned2020-11-20T00:38:37Z
dc.date.available2020-11-20T00:38:37Z
dc.date.issued2019-11-20
dc.identifier.citationHachoumi , L & Sillar , K T 2019 , ' Developmental stage-dependent switching in the neuromodulation of vertebrate locomotor central pattern generator networks ' , Developmental Neurobiology , vol. Early View . https://doi.org/10.1002/dneu.22725en
dc.identifier.issn1932-8451
dc.identifier.otherPURE: 263086532
dc.identifier.otherPURE UUID: 077a63b6-412e-4a0f-8be9-579147ab4b47
dc.identifier.otherScopus: 85075254448
dc.identifier.otherWOS: 000497349300001
dc.identifier.urihttp://hdl.handle.net/10023/21020
dc.description.abstractNeuromodulation plays important and stage‐dependent roles in regulating locomotor central pattern (CPG) outputs during vertebrate motor system development. Dopamine, serotonin and nitric oxide are three neuromodulators that potently influence CPG outputs in the development of Xenopus frog tadpole locomotion. However, their roles switch from predominantly inhibitory early in development to mainly excitatory at later stages. In this review, we compare the stage‐dependent switching in neuromodulation in Xenopus with other vertebrate systems, notably the mouse and the zebrafish, and highlight features that appear to be phylogenetically conserved.
dc.language.isoeng
dc.relation.ispartofDevelopmental Neurobiologyen
dc.rightsCopyright © 2019 Wiley Periodicals, Inc. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/dneu.22725en
dc.subjectLocomotionen
dc.subjectCPGen
dc.subjectDevelopmenten
dc.subjectSpinal corden
dc.subjectNeuromodulationen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subject.lccRC0321en
dc.titleDevelopmental stage-dependent switching in the neuromodulation of vertebrate locomotor central pattern generator networksen
dc.typeJournal itemen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1002/dneu.22725
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-11-20


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