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Developmental stage-dependent switching in the neuromodulation of vertebrate locomotor central pattern generator networks
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dc.contributor.author | Hachoumi, Lamia | |
dc.contributor.author | Sillar, Keith Thomas | |
dc.date.accessioned | 2020-11-20T00:38:37Z | |
dc.date.available | 2020-11-20T00:38:37Z | |
dc.date.issued | 2019-11-20 | |
dc.identifier.citation | Hachoumi , L & Sillar , K T 2019 , ' Developmental stage-dependent switching in the neuromodulation of vertebrate locomotor central pattern generator networks ' , Developmental Neurobiology , vol. Early View . https://doi.org/10.1002/dneu.22725 | en |
dc.identifier.issn | 1932-8451 | |
dc.identifier.other | PURE: 263086532 | |
dc.identifier.other | PURE UUID: 077a63b6-412e-4a0f-8be9-579147ab4b47 | |
dc.identifier.other | Scopus: 85075254448 | |
dc.identifier.other | WOS: 000497349300001 | |
dc.identifier.uri | http://hdl.handle.net/10023/21020 | |
dc.description.abstract | Neuromodulation plays important and stage‐dependent roles in regulating locomotor central pattern (CPG) outputs during vertebrate motor system development. Dopamine, serotonin and nitric oxide are three neuromodulators that potently influence CPG outputs in the development of Xenopus frog tadpole locomotion. However, their roles switch from predominantly inhibitory early in development to mainly excitatory at later stages. In this review, we compare the stage‐dependent switching in neuromodulation in Xenopus with other vertebrate systems, notably the mouse and the zebrafish, and highlight features that appear to be phylogenetically conserved. | |
dc.language.iso | eng | |
dc.relation.ispartof | Developmental Neurobiology | en |
dc.rights | Copyright © 2019 Wiley Periodicals, Inc. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/dneu.22725 | en |
dc.subject | Locomotion | en |
dc.subject | CPG | en |
dc.subject | Development | en |
dc.subject | Spinal cord | en |
dc.subject | Neuromodulation | en |
dc.subject | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | en |
dc.subject.lcc | RC0321 | en |
dc.title | Developmental stage-dependent switching in the neuromodulation of vertebrate locomotor central pattern generator networks | en |
dc.type | Journal item | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews.School of Psychology and Neuroscience | en |
dc.contributor.institution | University of St Andrews.Institute of Behavioural and Neural Sciences | en |
dc.identifier.doi | https://doi.org/10.1002/dneu.22725 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2020-11-20 |
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