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Understanding 'non-genetic' inheritance : insights from molecular-evolutionary crosstalk
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dc.contributor.author | Adrian-Kalchhauser, Irene | |
dc.contributor.author | Sultan, Sonia E. | |
dc.contributor.author | Shama, Lisa N.S. | |
dc.contributor.author | Spence-Jones, Helen Clare | |
dc.contributor.author | Tiso, Stefano | |
dc.contributor.author | Keller Valsecchi, Claudia Isabelle | |
dc.contributor.author | Weissing, Franz J. | |
dc.date.accessioned | 2020-11-19T17:30:02Z | |
dc.date.available | 2020-11-19T17:30:02Z | |
dc.date.issued | 2020-12 | |
dc.identifier.citation | Adrian-Kalchhauser , I , Sultan , S E , Shama , L N S , Spence-Jones , H C , Tiso , S , Keller Valsecchi , C I & Weissing , F J 2020 , ' Understanding 'non-genetic' inheritance : insights from molecular-evolutionary crosstalk ' , Trends in Ecology & Evolution , vol. 35 , no. 12 , pp. 1078-1089 . https://doi.org/10.1016/j.tree.2020.08.011 | en |
dc.identifier.issn | 0169-5347 | |
dc.identifier.other | PURE: 270685600 | |
dc.identifier.other | PURE UUID: 5a9e065b-6787-4e2b-b30b-afb4bc0eb486 | |
dc.identifier.other | crossref: 10.1016/j.tree.2020.08.011 | |
dc.identifier.other | Scopus: 85095452344 | |
dc.identifier.other | WOS: 000591286200010 | |
dc.identifier.uri | https://hdl.handle.net/10023/21016 | |
dc.description | The idea for this paper was initially proposed by I.A.-K. and was further developed by all authors in a workshop generously funded by grant No 789240 from the European Research Council (ERC) to F.J.W. S.E.S. acknowledges support from Wesleyan University and The John Templeton Foundation. | en |
dc.description.abstract | Understanding the evolutionary and ecological roles of 'non-genetic' inheritance (NGI) is daunting due to the complexity and diversity of epigenetic mechanisms. We draw on insights from molecular and evolutionary biology perspectives to identify three general features of 'non-genetic' inheritance systems: (i) they are functionally interdependent with, rather than separate from, DNA sequence; (ii) precise mechanisms vary phylogenetically and operationally; and (iii) epigenetic elements are probabilistic, interactive regulatory factors and not deterministic 'epialleles' with defined genomic locations and effects. We discuss each of these features and offer recommendations for future empirical and theoretical research that implements a unifying inherited gene regulation (IGR) approach to studies of 'non-genetic' inheritance. | |
dc.format.extent | 12 | |
dc.language.iso | eng | |
dc.relation.ispartof | Trends in Ecology & Evolution | en |
dc.rights | Copyright © 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en |
dc.subject | Epigenetics | en |
dc.subject | Extended inheritance | en |
dc.subject | Epiallelic variation | en |
dc.subject | Theoretical models | en |
dc.subject | Transgenerational effects | en |
dc.subject | Inherited gene regulation | en |
dc.subject | QH301 Biology | en |
dc.subject.lcc | QH301 | en |
dc.title | Understanding 'non-genetic' inheritance : insights from molecular-evolutionary crosstalk | en |
dc.type | Journal item | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.identifier.doi | https://doi.org/10.1016/j.tree.2020.08.011 | |
dc.description.status | Peer reviewed | en |
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