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dc.contributor.authorAdrian-Kalchhauser, Irene
dc.contributor.authorSultan, Sonia E.
dc.contributor.authorShama, Lisa N.S.
dc.contributor.authorSpence-Jones, Helen Clare
dc.contributor.authorTiso, Stefano
dc.contributor.authorKeller Valsecchi, Claudia Isabelle
dc.contributor.authorWeissing, Franz J.
dc.identifier.citationAdrian-Kalchhauser , I , Sultan , S E , Shama , L N S , Spence-Jones , H C , Tiso , S , Keller Valsecchi , C I & Weissing , F J 2020 , ' Understanding 'non-genetic' inheritance : insights from molecular-evolutionary crosstalk ' , Trends in Ecology & Evolution , vol. 35 , no. 12 , pp. 1078-1089 .
dc.identifier.otherPURE: 270685600
dc.identifier.otherPURE UUID: 5a9e065b-6787-4e2b-b30b-afb4bc0eb486
dc.identifier.othercrossref: 10.1016/j.tree.2020.08.011
dc.identifier.otherScopus: 85095452344
dc.identifier.otherWOS: 000591286200010
dc.descriptionThe idea for this paper was initially proposed by I.A.-K. and was further developed by all authors in a workshop generously funded by grant No 789240 from the European Research Council (ERC) to F.J.W. S.E.S. acknowledges support from Wesleyan University and The John Templeton Foundation.en
dc.description.abstractUnderstanding the evolutionary and ecological roles of 'non-genetic' inheritance (NGI) is daunting due to the complexity and diversity of epigenetic mechanisms. We draw on insights from molecular and evolutionary biology perspectives to identify three general features of 'non-genetic' inheritance systems: (i) they are functionally interdependent with, rather than separate from, DNA sequence; (ii) precise mechanisms vary phylogenetically and operationally; and (iii) epigenetic elements are probabilistic, interactive regulatory factors and not deterministic 'epialleles' with defined genomic locations and effects. We discuss each of these features and offer recommendations for future empirical and theoretical research that implements a unifying inherited gene regulation (IGR) approach to studies of 'non-genetic' inheritance.
dc.relation.ispartofTrends in Ecology & Evolutionen
dc.rightsCopyright © 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (
dc.subjectExtended inheritanceen
dc.subjectEpiallelic variationen
dc.subjectTheoretical modelsen
dc.subjectTransgenerational effectsen
dc.subjectInherited gene regulationen
dc.subjectQH301 Biologyen
dc.titleUnderstanding 'non-genetic' inheritance : insights from molecular-evolutionary crosstalken
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.description.statusPeer revieweden

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