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Sex differences in oncogenic mutational processes

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dc.contributor.authorLi, Constance H.
dc.contributor.authorProkopec, Stephenie D.
dc.contributor.authorSun, Ren X.
dc.contributor.authorYousif, Fouad
dc.contributor.authorSchmitz, Nathaniel
dc.contributor.authorPCAWG Tumour Subtypes and Clinical Translation
dc.contributor.authorBoutros, Paul C.
dc.contributor.authorPCAWG Consortium
dc.date.accessioned2020-11-16T16:30:07Z
dc.date.available2020-11-16T16:30:07Z
dc.date.issued2020-08-28
dc.identifier271270031
dc.identifierbc1a77f7-52b0-4066-a9ff-cb3dd8bea6de
dc.identifier85079052881
dc.identifier.citationLi , C H , Prokopec , S D , Sun , R X , Yousif , F , Schmitz , N , PCAWG Tumour Subtypes and Clinical Translation , Boutros , P C & PCAWG Consortium 2020 , ' Sex differences in oncogenic mutational processes ' , Nature Communications , vol. 11 , 4330 . https://doi.org/10.1038/s41467-020-17359-2en
dc.identifier.issn2041-1723
dc.identifier.otherORCID: /0000-0002-7876-7338/work/83889937
dc.identifier.urihttps://hdl.handle.net/10023/20993
dc.descriptionThis study was conducted with the support of the Ontario Institute for Cancer Research to P.C.B. through funding provided by the Government of Ontario. This work was supported by the Discovery Frontiers: Advancing Big Data Science in Genomics Research program, which is jointly funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada, the Canadian Institutes of Health Research (CIHR), Genome Canada and the Canada Foundation for Innovation (CFI). P.C.B. was supported by a Terry Fox Research Institute New Investigator Award and a CIHR New Investigator Award. This work was supported by an NSERC Discovery grant and by Canadian Institutes of Health Research, grant #SVB-145586, to P.C.B. This work was supported by the NIH/NCI under award number P30CA016042 and an operating grant from the National Cancer Institute Early Detection Research Network (1U01CA214194-01).en
dc.description.abstractSex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.
dc.format.extent24
dc.format.extent2296581
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectCancer geneticsen
dc.subjectCancer genomicsen
dc.subjectGenome informaticsen
dc.subjectOncogenesen
dc.subjectQH426 Geneticsen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subject3rd-DASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQH426en
dc.subject.lccRC0254en
dc.titleSex differences in oncogenic mutational processesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.contributor.institutionUniversity of St Andrews. Statisticsen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doi10.1038/s41467-020-17359-2
dc.description.statusPeer revieweden


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