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dc.contributor.authorVidela, E. A.
dc.contributor.authorGiayetto, O.
dc.contributor.authorFernández, M. E.
dc.contributor.authorChacana, P. A.
dc.contributor.authorMarín, R. H.
dc.contributor.authorNazar, F. N.
dc.date.accessioned2020-11-13T15:30:08Z
dc.date.available2020-11-13T15:30:08Z
dc.date.issued2020-10-23
dc.identifier.citationVidela , E A , Giayetto , O , Fernández , M E , Chacana , P A , Marín , R H & Nazar , F N 2020 , ' Immediate and transgenerational effects of thymol supplementation, inactivated Salmonella and chronic heat stress on representative immune variables of Japanese quail ' , Scientific Reports , vol. 10 , 18152 . https://doi.org/10.1038/s41598-020-74547-2en
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 271203349
dc.identifier.otherPURE UUID: aee14c29-3903-4dab-a985-9eadc0d10020
dc.identifier.otherScopus: 85093653401
dc.identifier.otherPubMed: 33097768
dc.identifier.otherWOS: 000586485700010
dc.identifier.urihttp://hdl.handle.net/10023/20970
dc.descriptionE.A.V. holds a research fellowship from Fondo para la Investigación Científica y Tecnológica (FonCyT-Project 2014-2764). This research was supported by grants from FonCyT (Projects 2016-1969 and 2018-2781) and Secretaría de Ciencia y Técnica, Universidad Nacional de Córdoba (SECyT-UNC, Project 30820150100031CB).en
dc.description.abstractEnvironmental challenges are integrated in the inmunoneuroendocrine interplay, impacting the immune system of the challenged individuals, and potentially implying transgenerational effects on their offspring. This study addressed whether dietary supplementation with thymol can modulate the immune response of adult Japanese quail when simultaneously exposed to an inoculum of inactivated Salmonella Enteritidis and a chronic heat stress (CHS). We also evaluated whether the experienced situations by adults can affect the immune response of their undisturbed offspring. In the parental generation, supplemented quail exposed to CHS had a higher inflammatory response and similar values of the heterophil/lymphocyte (H/L) ratio than those that were not supplemented. In their offspring, those chicks whose parents were exposed to CHS showed higher inflammatory response and lower antibody production. Regarding the H/L ratio, chicks whose parents were supplemented showed lower H/L ratio values. Dietary supplementation with thymol partially and positively modulated the inflammatory response and avoided H/L ratio alteration in the parental generation exposed to high environmental temperatures, suggesting these adults were better at dealing with the challenge. The lower H/L ratio values in the offspring suggests that chicks are more capable to deal with potential stressful situations associated with conventional breeding conditions.
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofScientific Reportsen
dc.rightsCopyright © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en
dc.subjectAnimal physiologyen
dc.subjectImmunologyen
dc.subjectQL Zoologyen
dc.subjectQR180 Immunologyen
dc.subjectGeneralen
dc.subjectNDASen
dc.subject.lccQLen
dc.subject.lccQR180en
dc.titleImmediate and transgenerational effects of thymol supplementation, inactivated Salmonella and chronic heat stress on representative immune variables of Japanese quailen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.identifier.doihttps://doi.org/10.1038/s41598-020-74547-2
dc.description.statusPeer revieweden


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