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Generation and reactivity of C(1)-ammonium enolates using isothiourea catalysis
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dc.contributor.author | McLaughlin, Calum | |
dc.contributor.author | Smith, Andrew D. | |
dc.date.accessioned | 2020-11-10T17:30:06Z | |
dc.date.available | 2020-11-10T17:30:06Z | |
dc.date.issued | 2020-11-10 | |
dc.identifier.citation | McLaughlin , C & Smith , A D 2020 , ' Generation and reactivity of C(1)-ammonium enolates using isothiourea catalysis ' , Chemistry - A European Journal , vol. Early View . https://doi.org/10.1002/chem.202002059 | en |
dc.identifier.issn | 0947-6539 | |
dc.identifier.other | PURE: 268566064 | |
dc.identifier.other | PURE UUID: 23705d8a-707e-4f76-ba71-16528e4c5a21 | |
dc.identifier.other | WOS: 000587734000001 | |
dc.identifier.other | Scopus: 85096780741 | |
dc.identifier.uri | https://hdl.handle.net/10023/20941 | |
dc.description | Funding: UK EPSRC (EP/M508214/1, C.M.). Royal Society for a Wolfson Research Merit Award (A.D.S.). | en |
dc.description.abstract | C(1)-ammonium enolates are powerful, catalytically generated synthetic intermediates applied in the enantioselective α-functionalization of carboxylic acid derivatives. This review describes the recent developments in the generation and application of C(1)-ammonium enolates from various precursors (carboxylic acids, anhydrides, acyl imidazoles, aryl esters, α-diazoketones, alkyl halides) using isothiourea Lewis base organocatalysts. Their synthetic utility in intra- and intermolecular enantioselective C-C and C-X bond forming processes on reaction with various electrophiles will be showcased utilizing two distinct catalyst turnover approaches. | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemistry - A European Journal | en |
dc.rights | Copyright © 2020 The Authors. Published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en |
dc.subject | Aryloxides | en |
dc.subject | C(1)-ammonium enolates | en |
dc.subject | Catalyst turnover | en |
dc.subject | Formal cycloaddition | en |
dc.subject | Isothioureas | en |
dc.subject | QD Chemistry | en |
dc.subject.lcc | QD | en |
dc.title | Generation and reactivity of C(1)-ammonium enolates using isothiourea catalysis | en |
dc.type | Journal item | en |
dc.contributor.sponsor | The Royal Society | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. University of St Andrews | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.identifier.doi | https://doi.org/10.1002/chem.202002059 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2020-11-10 | |
dc.identifier.grantnumber | WM140071 | en |
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