Show simple item record

Files in this item

Thumbnail

Item metadata

dc.contributor.authorMcLaughlin, Calum
dc.contributor.authorSmith, Andrew D.
dc.date.accessioned2020-11-10T17:30:06Z
dc.date.available2020-11-10T17:30:06Z
dc.date.issued2020-11-10
dc.identifier.citationMcLaughlin , C & Smith , A D 2020 , ' Generation and reactivity of C(1)-ammonium enolates using isothiourea catalysis ' , Chemistry - A European Journal , vol. Early View . https://doi.org/10.1002/chem.202002059en
dc.identifier.issn0947-6539
dc.identifier.otherPURE: 268566064
dc.identifier.otherPURE UUID: 23705d8a-707e-4f76-ba71-16528e4c5a21
dc.identifier.otherWOS: 000587734000001
dc.identifier.otherScopus: 85096780741
dc.identifier.urihttps://hdl.handle.net/10023/20941
dc.descriptionFunding: UK EPSRC (EP/M508214/1, C.M.). Royal Society for a Wolfson Research Merit Award (A.D.S.).en
dc.description.abstractC(1)-ammonium enolates are powerful, catalytically generated synthetic intermediates applied in the enantioselective α-functionalization of carboxylic acid derivatives. This review describes the recent developments in the generation and application of C(1)-ammonium enolates from various precursors (carboxylic acids, anhydrides, acyl imidazoles, aryl esters, α-diazoketones, alkyl halides) using isothiourea Lewis base organocatalysts. Their synthetic utility in intra- and intermolecular enantioselective C-C and C-X bond forming processes on reaction with various electrophiles will be showcased utilizing two distinct catalyst turnover approaches.
dc.language.isoeng
dc.relation.ispartofChemistry - A European Journalen
dc.rightsCopyright © 2020 The Authors. Published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectAryloxidesen
dc.subjectC(1)-ammonium enolatesen
dc.subjectCatalyst turnoveren
dc.subjectFormal cycloadditionen
dc.subjectIsothioureasen
dc.subjectQD Chemistryen
dc.subject.lccQDen
dc.titleGeneration and reactivity of C(1)-ammonium enolates using isothiourea catalysisen
dc.typeJournal itemen
dc.contributor.sponsorThe Royal Societyen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. University of St Andrewsen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.identifier.doihttps://doi.org/10.1002/chem.202002059
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-11-10
dc.identifier.grantnumberWM140071en


This item appears in the following Collection(s)

Show simple item record