Antibacterial efficacy from NO-releasing MOF–polymer films
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The formulation and antibacterial efficacy of nitric oxide (NO)-releasing MOF–polyurethane films are reported for the first time. Uniform standalone films were successfully prepared containing 1, 5, 10, and 15 wt% CPO-27 (Ni). The MOF within each film was successfully activated and loaded with NO. Adsorption and release profiles are reported for the films and show that while the polymer influences the quantity of NO adsorbed and stored by the MOF and the time scale of release; the proportion of stored NO that is released is dependent on wt% loading of MOF in the film. In a cytotoxicity assay, the formulations exhibited very low toxicity (<20% cell death), and this toxicity was attributed to the NO rather than the MOF. Antibacterial data against E. coli and S. aureus indicated that bactericidal efficacy can be achieved in 5 hours from 1 wt% films, and within 1 hour for films containing at least 5 wt% MOF.
Duncan , M J , Wheatley , P S , Coghill , E M , Vornholt , S M , Warrender , S J , Megson , I L & Morris , R E 2020 , ' Antibacterial efficacy from NO-releasing MOF–polymer films ' , Materials Advances , vol. 1 , no. 7 , pp. 2509-2519 . https://doi.org/10.1039/d0ma00650e
Copyright © 2020 The Author(s). Open Access Article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
DescriptionAuthors gratefully thank the following funding sources for financial support: Scottish Enterprise (POC13), EPSRC (EP/K005499/1 and Capital for Great Technologies grant EP/L017008/1), European Social Fund Studentship and the University of St Andrews School of Chemistry.
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