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dc.contributor.authorSafarpour, Hanie
dc.contributor.authorCevik, Muge
dc.contributor.authorZarean, Mehdi
dc.contributor.authorBarac, Aleksandra
dc.contributor.authorHatam-Nahavandi, Kareem
dc.contributor.authorRahimi, Mohammad Taghi
dc.contributor.authorBannazadeh Baghi, Hossein
dc.contributor.authorKoshki, Tohid Jafari
dc.contributor.authorPagheh, Abdol Sattar
dc.contributor.authorShahrivar, Firooz
dc.contributor.authorEbrahimi, Mina
dc.contributor.authorAhmadpour, Ehsan
dc.date.accessioned2020-11-09T00:38:26Z
dc.date.available2020-11-09T00:38:26Z
dc.date.issued2020-03-01
dc.identifier.citationSafarpour , H , Cevik , M , Zarean , M , Barac , A , Hatam-Nahavandi , K , Rahimi , M T , Bannazadeh Baghi , H , Koshki , T J , Pagheh , A S , Shahrivar , F , Ebrahimi , M & Ahmadpour , E 2020 , ' Global status of Toxoplasma gondii infection and associated risk factors in people living with HIV : a systematic review and meta-analysis ' , AIDS , vol. 34 , no. 3 , pp. 469-474 . https://doi.org/10.1097/QAD.0000000000002424en
dc.identifier.issn0269-9370
dc.identifier.otherPURE: 263235541
dc.identifier.otherPURE UUID: 79f963d7-1d39-4d53-a7fb-a8c0c3a518c5
dc.identifier.otherPubMed: 31714356
dc.identifier.otherORCID: /0000-0003-1133-3874/work/64698140
dc.identifier.otherScopus: 85078693420
dc.identifier.otherWOS: 000544898400014
dc.identifier.urihttp://hdl.handle.net/10023/20925
dc.description.abstractOBJECTIVE: Toxoplasma infection remains as the most common cause of focal brain lesions among people living with HIV (PLHIV) despite the decline in opportunistic infections with the introduction of antiretroviral treatment. This study was conducted to provide a summary of evidence about the seroprevalence of Toxoplasma gondii and prevalence of active T. gondii infection and associated risk factors among PLHIV. DESIGN: PRISMA guidelines were followed. Scopus, PubMed, Science Direct, and EMBASE were searched from 1997 to July 2018. All peer-reviewed original research articles describing T. gondii infection among PLHIV with different diagnostic methods were included. METHODS: Incoherence and heterogeneity between studies were quantified by I2 index and Cochran's Q test. Publication and population bias were assessed with funnel plots and Egger's regression asymmetry test. All statistical analyses were performed using StatsDirect. RESULTS: A total of 111 studies from 37 countries assessing 66,139 blood samples were included in this study. The pooled prevalence of T. gondii infection among PLHIV was 3.24% by IgM and 26.22% by molecular methods using the random-effects model. Pooled seroprevalence of T. gondii by IgG was 44.22%. There was a relationship between Toxoplasma prevalence and gender, raw meat consumption, contact with cat and knowledge about toxoplasmosis. CONCLUSION: High Toxoplasma seroprevalence among PLHIV observed in this study emphasizes the need for implementing screening and prophylaxis tailored to the local context. Owing to the serious and significant clinical manifestations of the parasite in case of reactivation, early identification of seropositivity for initiating prophylaxis among those with a CD4 count of <200cells/mL is recommended.
dc.language.isoeng
dc.relation.ispartofAIDSen
dc.rightsCopyright © 2019 Wolters Kluwer Health, Inc. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1097/QAD.0000000000002424en
dc.subjectAIDSen
dc.subjectHIVen
dc.subjectImmunocompromiseden
dc.subjectPrevalenceen
dc.subjectToxoplasma gondiien
dc.subjectToxoplasmosisen
dc.subjectQR180 Immunologyen
dc.subjectI-PWen
dc.subject.lccQR180en
dc.titleGlobal status of Toxoplasma gondii infection and associated risk factors in people living with HIV : a systematic review and meta-analysisen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.1097/QAD.0000000000002424
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-11-09


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