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dc.contributor.authorFerrario, Cinzia
dc.contributor.authorSugni, Michela
dc.contributor.authorSomorjai, Ildiko Maureen Lara
dc.contributor.authorBallarin, Loriano
dc.date.accessioned2020-10-22T11:30:10Z
dc.date.available2020-10-22T11:30:10Z
dc.date.issued2020-10-20
dc.identifier.citationFerrario , C , Sugni , M , Somorjai , I M L & Ballarin , L 2020 , ' Beyond adult stem cells : dedifferentiation as a unifying mechanism underlying regeneration in invertebrate deuterostomes ' , Frontiers in Cell and Developmental Biology , vol. 8 , 587320 . https://doi.org/10.3389/fcell.2020.587320en
dc.identifier.issn2296-634X
dc.identifier.otherPURE: 270621005
dc.identifier.otherPURE UUID: 9d6d987e-b839-4857-8db3-1fc3cb6dcb52
dc.identifier.otherScopus: 85094954252
dc.identifier.otherWOS: 000583832600001
dc.identifier.urihttp://hdl.handle.net/10023/20812
dc.descriptionThis work was partly supported by a grant from the Italian MIUR. Research in the Somorjai lab is supported by the Wellcome Trust ISSF. Research in the Sugni lab is supported by a grant from the University of Milan (Linea 2).en
dc.description.abstractThe diversity of regenerative phenomena seen in adult metazoans, as well as their underlying mechanistic bases, are still far from being comprehensively understood. Reviewing both ultrastructural and molecular data, the present work aims to showcase the increasing relevance of invertebrate deuterostomes, i.e. echinoderms, hemichordates, cephalochordates and tunicates, as invaluable models to study cellular aspects of adult regeneration. Our comparative approach suggests a fundamental contribution of local dedifferentiation -rather than mobilisation of resident undifferentiated stem cells- as an important cellular mechanism contributing to regeneration in these groups. Thus, elucidating the cellular origins, recruitment and fate of cells, as well as the molecular signals underpinning tissue regrowth in regeneration-competent deuterostomes, will provide the foundation for future research in tackling the relatively limited regenerative abilities of vertebrates, with clear applications in regenerative medicine.
dc.format.extent25
dc.language.isoeng
dc.relation.ispartofFrontiers in Cell and Developmental Biologyen
dc.rightsCopyright © 2020 Ferrario, Sugni, Somorjai and Ballarin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectAdult invertebrate deuterostomesen
dc.subjectDedifferentiationen
dc.subjectProgenitor cellsen
dc.subjectStem cellsen
dc.subjectRegenerationen
dc.subjectQH301 Biologyen
dc.subject.lccQH301en
dc.titleBeyond adult stem cells : dedifferentiation as a unifying mechanism underlying regeneration in invertebrate deuterostomesen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.identifier.doihttps://doi.org/10.3389/fcell.2020.587320
dc.description.statusPeer revieweden


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