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dc.contributor.authorLange, Christoph
dc.contributor.authorAarnoutse, Rob
dc.contributor.authorChesov, Dumitru
dc.contributor.authorvan Crevel, Reinout
dc.contributor.authorGillespie, Stephen H.
dc.contributor.authorGrobbel, Hans-Peter
dc.contributor.authorKalsdorf, Barbara
dc.contributor.authorKontsevaya, Irina
dc.contributor.authorvan Laarhoven, Arjan
dc.contributor.authorNishiguchi, Tomoki
dc.contributor.authorMandalakas, Anna
dc.contributor.authorMerker, Matthias
dc.contributor.authorNiemann, Stefan
dc.contributor.authorKöhler, Niklas
dc.contributor.authorHeyckendorf, Jan
dc.contributor.authorReimann, Maja
dc.contributor.authorRuhwald, Morten
dc.contributor.authorSanchez-Carballo, Patricia
dc.contributor.authorSchwudke, Dominik
dc.contributor.authorWaldow, Franziska
dc.contributor.authorDiNardo, Andrew R.
dc.identifier.citationLange , C , Aarnoutse , R , Chesov , D , van Crevel , R , Gillespie , S H , Grobbel , H-P , Kalsdorf , B , Kontsevaya , I , van Laarhoven , A , Nishiguchi , T , Mandalakas , A , Merker , M , Niemann , S , Köhler , N , Heyckendorf , J , Reimann , M , Ruhwald , M , Sanchez-Carballo , P , Schwudke , D , Waldow , F & DiNardo , A R 2020 , ' Perspective for precision medicine for tuberculosis ' , Frontiers in Immunology , vol. 11 , 566608 .
dc.identifier.otherBibtex: 10.3389/fimmu.2020.566608
dc.descriptionFunding: German Center for Infection Research (DZIF) Clinical TB TTU-TB 02.704. The publication of this article was supported by the Open Access Publication Fund of the Leibniz Association.en
dc.description.abstractTuberculosis is a bacterial infectious disease that is mainly transmitted from human to human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an infectious disease world-wide. In the past decade, the number of patients affected by tuberculosis has increased by ~20 percent and the emergence of drug-resistant strains of Mycobacterium tuberculosis challenges the goal of elimination of tuberculosis in the near future. For the last 50 years, management of patients with tuberculosis has followed a standardized management approach. This standardization neglects the variation in human susceptibility to infection, immune response, the pharmacokinetics of drugs, and the individual duration of treatment needed to achieve relapse-free cure. Here we propose a package of precision medicine-guided therapies that has the prospect to drive clinical management decisions, based on both host immunity and M. tuberculosis strains genetics. Recently, important scientific discoveries and technological advances have been achieved that provide a perspective for individualized rather than standardized management of patients with tuberculosis. For the individual selection of best medicines and host-directed therapies, personalized drug dosing, and treatment durations, physicians treating patients with tuberculosis will be able to rely on these advances in systems biology and to apply them at the bedside.
dc.relation.ispartofFrontiers in Immunologyen
dc.subjectPrecision medicineen
dc.subjectTailor-made regimenen
dc.subjectMycobacterial genotypesen
dc.subjectQR180 Immunologyen
dc.subjectRM Therapeutics. Pharmacologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titlePerspective for precision medicine for tuberculosisen
dc.typeJournal itemen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Infection and Global Health Divisionen
dc.contributor.institutionUniversity of St Andrews. Global Health Implementation Groupen
dc.contributor.institutionUniversity of St Andrews. Gillespie Groupen
dc.contributor.institutionUniversity of St Andrews. Infection Groupen
dc.description.statusPeer revieweden

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