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dc.contributor.authorZaric, Bozidarka L.
dc.contributor.authorRadovanovic, Jelena N.
dc.contributor.authorGluvic, Zoran
dc.contributor.authorStewart, Alan J.
dc.contributor.authorEssak, Magbubah
dc.contributor.authorMotwalli, Olaa
dc.contributor.authorGojobori, Takashi
dc.contributor.authorIsenovic, Esma R.
dc.identifier.citationZaric , B L , Radovanovic , J N , Gluvic , Z , Stewart , A J , Essak , M , Motwalli , O , Gojobori , T & Isenovic , E R 2020 , ' Atherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymes ' , Frontiers in Immunology , vol. 11 , 551758 .
dc.identifier.otherPURE: 269785311
dc.identifier.otherPURE UUID: 45fe0ccb-a30c-48df-97fa-6d8e5338deff
dc.identifier.otherScopus: 85092508235
dc.identifier.otherWOS: 000579031100001
dc.descriptionThis work is part of the collaboration between the Laboratory of Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia, and King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal, Saudi Arabia. The research was funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia and by the KAUST grant OSR#4129 (E.R.I I TG). T.G. was supported by the KAUST Base Research Funds BAS/1/1059-01-01, respectively, while M.E. was supported by the KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01.en
dc.description.abstractCardiovascular disease is the leading global health concern and responsible for more deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory disease in the arterial wall, which underpins several types of cardiovascular disease. It has emerged that a strong relationship exists between alterations in amino acid (AA) metabolism and the development of atherosclerosis. Recent studies have reported positive correlations between levels of branched-chain amino acids (BCAAs) such as leucine, valine, and isoleucine in plasma and the occurrence of metabolic disturbances. Elevated serum levels of BCAAs indicate a high cardiometabolic risk. Thus, BCAAs may also impact atherosclerosis prevention and offer a novel therapeutic strategy for specific individuals at risk of coronary events. The metabolism of AAs, such as L-arginine, homoarginine, and L-tryptophan, is recognized as a critical regulator of vascular homeostasis. Dietary intake of homoarginine, taurine, and glycine can improve atherosclerosis by endothelium remodeling. Available data also suggest that the regulation of AA metabolism by indoleamine 2,3-dioxygenase (IDO) and arginases (1 and 2) are mediated through various immunological signals and that immunosuppressive AA metabolizing enzymes are promising therapeutic targets against atherosclerosis. Further clinical studies and basic studies that make use of animal models are required. Here we review recent data examining links between AA metabolism and the development of atherosclerosis.
dc.relation.ispartofFrontiers in Immunologyen
dc.rightsCopyright © 2020 Zaric, Radovanovic, Gluvic, Stewart, Essack, Motwalli, Gojobori and Isenovic. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectAmino acidsen
dc.subjectBranched-chain amino acidsen
dc.subjectQR180 Immunologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleAtherosclerosis linked to aberrant amino acid metabolism and immunosuppressive amino acid catabolizing enzymesen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.description.statusPeer revieweden

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