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dc.contributor.authorAl-Shahi Salman, Rustam
dc.contributor.authorMinks, David P.
dc.contributor.authorMitra, Dipayan
dc.contributor.authorRodrigues, Mark A.
dc.contributor.authorBhatnagar, Priya
dc.contributor.authordu Plessis, Johann C.
dc.contributor.authorJoshi, Yogish
dc.contributor.authorDennis, Martin S.
dc.contributor.authorMurray, Gordon D.
dc.contributor.authorNewby, David E.
dc.contributor.authorSandercock, Peter A.G.
dc.contributor.authorSprigg, Nikola
dc.contributor.authorStephen, Jacqueline
dc.contributor.authorSudlow, Cathie L.M.
dc.contributor.authorWerring, David J.
dc.contributor.authorWhiteley, William
dc.contributor.authorWardlaw, Joanna M.
dc.contributor.authorWhite, Philip M.
dc.contributor.authorBaigent, Colin
dc.contributor.authorLasserson, Daniel
dc.contributor.authorSullivan, Frank
dc.contributor.authorCarrie, Johanna
dc.contributor.authorRojas, Javier
dc.contributor.authorAmoils, Shannon
dc.contributor.authorBamford, John
dc.contributor.authorArmitage, Jane
dc.contributor.authorRinkel, Gabriel
dc.contributor.authorLowe, Gordon
dc.contributor.authorEmberson, Jonathan
dc.contributor.authorInnes, Karen
dc.contributor.authorDinsmore, Lynn
dc.contributor.authorDrever, Jonathan
dc.contributor.authorWilliams, Carol
dc.contributor.authorPerry, David
dc.contributor.authorMcGill, Connor
dc.contributor.authorBuchanan, David
dc.contributor.authorWalker, Allan
dc.contributor.authorHutchison, Aidan
dc.contributor.authorMatthews, Christopher
dc.contributor.authorFraser, Ruth
dc.contributor.authorMcGrath, Aileen
dc.contributor.authorDeary, Ann
dc.contributor.authorAnderson, Rosemary
dc.contributor.authorWalker, Pauli
dc.contributor.authorHansen, Christian
dc.contributor.authorParker, Richard
dc.contributor.authorRodriguez, Aryelly
dc.contributor.authorMacleod, Malcolm
dc.contributor.authorGattringer, Thomas
dc.contributor.authorPalmer, Jeb
dc.contributor.authorSakka, Eleni
dc.contributor.authorAdil-Smith, Jennifer
dc.contributor.authorMinks, David
dc.contributor.authordu Plessis, Johannes
dc.contributor.authorLerpiniere, Christine
dc.contributor.authorO'Brien, Richard
dc.contributor.authorBurgess, Seona
dc.contributor.authorMead, Gillian
dc.contributor.authorPaulton, Ruth
dc.contributor.authorDoubal, Fergus
dc.contributor.authorMcCormick, Katrina
dc.contributor.authorHunter, Neil
dc.contributor.authorTaylor, Pat
dc.contributor.authorParakramawansha, Ruwan
dc.contributor.authorPerry, Jack
dc.contributor.authorBlair, Gordon
dc.contributor.authorMacRaild, Allan
dc.contributor.authorParry-Jones, Adrian
dc.contributor.authorJohnes, Mary
dc.contributor.authorLee, Stephanie
dc.contributor.authorShaw, Kelly Marie
dc.contributor.authorBurger, Ilse
dc.contributor.authorPunter, Martin
dc.contributor.authorIngham, Andrea
dc.contributor.authorPerez, Jane
dc.contributor.authorNaing, Zin
dc.contributor.authorMorell, Jordi
dc.contributor.authorMarsden, Tracy
dc.contributor.authorHall, Andrea
dc.contributor.authorMarshall, Sally
dc.contributor.authorHarrison, Louise
dc.contributor.authorJarapa, Rowilson
dc.contributor.authorWood, Edith
dc.contributor.authorO'Loughlin, Victoria
dc.contributor.authorCohen, David
dc.contributor.authorDavies, Silvie
dc.contributor.authorNjoku, Kelechi
dc.contributor.authorMpelembue, Mushiya
dc.contributor.authorBurgess, Laura
dc.contributor.authorLicenik, Radim
dc.contributor.authorNgwako, Mmua
dc.contributor.authorNisar, Nabeela
dc.contributor.authorNiranchanan, Rangah
dc.contributor.authorRoganova, Tatjana
dc.contributor.authorBathula, Rajaram
dc.contributor.authorDevine, Joseph
dc.contributor.authorDavid, Anette
dc.contributor.authorOshodi, Anne
dc.contributor.authorGuo, Fenglin
dc.contributor.authorOwoyele, Emmanuelle
dc.contributor.authorSukdeo, Varthi
dc.contributor.authorBallantine, Robert
dc.contributor.authorAbbdul-saheb, Mudhar
dc.contributor.authorChamberlain, Angela
dc.contributor.authorChandrakumar, Aberami
dc.contributor.authorPoku, Philip
dc.contributor.authorHarkness, Kirsty
dc.contributor.authorBlank, Catrin
dc.contributor.authorRichards, Emma
dc.contributor.authorAli, Ali
dc.contributor.authorKibutu, Faith
dc.contributor.authorBalitska, Olesia
dc.contributor.authorBirchall, Kathryn
dc.contributor.authorBayliss, Pauline
dc.contributor.authorDoyle, Clare
dc.contributor.authorStocks, Kathy
dc.contributor.authorMajis, Arshad
dc.contributor.authorHowe, Jo
dc.contributor.authorKamara, Christine
dc.contributor.authorBarron, Luke
dc.contributor.authorMaatouk, Ahmad
dc.contributor.authorLindert, Ralf
dc.contributor.authorDakin, Katy
dc.contributor.authorRedgrave, Jessica
dc.contributor.authorBhaskaran, Biju
dc.contributor.authorSalih, Isam
dc.contributor.authorKelly, Debs
dc.contributor.authorSzabo, Susan
dc.contributor.authorTomlin, Dawn
dc.contributor.authorBearne, Helen
dc.contributor.authorBuxton, Jean
dc.contributor.authorFitzell, Pauline
dc.contributor.authorAyres, Georgina
dc.contributor.authorSaulat, Afaq
dc.contributor.authorHoran, Kathleen
dc.contributor.authorGarfield-Smith, Joanne
dc.contributor.authorBhakri, Harbens
dc.contributor.authorGuyler, Paul
dc.contributor.authorSinha, Devesh
dc.contributor.authorLoganathan, Thayalini
dc.contributor.authorSiddiqui, Amber
dc.contributor.authorSiddiqui, Anwer
dc.contributor.authorCoward, Lucy
dc.contributor.authorKunhunny, Swapna
dc.contributor.authorTysoe, Sharon
dc.contributor.authorOrath Prabakaran, Rajalakshmi
dc.contributor.authorKelavkar, Shyam
dc.contributor.authorRashmi, Sindhu
dc.contributor.authorNgo, David
dc.contributor.authorNg, Kheng Xiong
dc.contributor.authorMenon, Nisha
dc.contributor.authorShah, Sweni
dc.contributor.authorBarber, Mark
dc.contributor.authorEsson, Derek
dc.contributor.authorBrodie, Fiona
dc.contributor.authorAnjum, Talat
dc.contributor.authorWani, Mushtaq
dc.contributor.authorKrishnan, Manju
dc.contributor.authorQuinn, Leanne
dc.contributor.authorSpencer, Jayne
dc.contributor.authorJones, Terry
dc.contributor.authorThompson-Jones, Helen
dc.contributor.authorDacey, Lynne
dc.contributor.authorChenna, Srikanth
dc.contributor.authorStorton, Sharon
dc.contributor.authorThomas, Sarah
dc.contributor.authorBeaty, Teresa
dc.contributor.authorTreadwell, Shelley
dc.contributor.authorDavies, Caroline
dc.contributor.authorTucker, Susan
dc.contributor.authorConnor, Lynda
dc.contributor.authorSlade, Peter
dc.contributor.authorGainard, Glyn
dc.contributor.authorMuddegowda, Girish
dc.contributor.authorSanyal, Ranjan
dc.contributor.authorRemegoso, Alda
dc.contributor.authorAbano, Nenette
dc.contributor.authorCausley, Chelsea
dc.contributor.authorCarpio, Racquel
dc.contributor.authorStevens, Stephanie
dc.contributor.authorButler, Adrian
dc.contributor.authorVarquez, Resti
dc.contributor.authorDenic, Hayley
dc.contributor.authorAlipio, Francis
dc.contributor.authorMoores, Andrew
dc.contributor.authorBarry, Adrian
dc.contributor.authorMaguire, Holly
dc.contributor.authorGrocott, Jeanette
dc.contributor.authorFinney, Kay
dc.contributor.authorLyjko, Sue
dc.contributor.authorRoffe, Christine
dc.contributor.authorHiden, Joanne
dc.contributor.authorFerdinand, Phillip
dc.contributor.authorCvoro, Vera
dc.contributor.authorUllah, Khalil
dc.contributor.authorChapman, Nicola
dc.contributor.authorCouser, Mandy
dc.contributor.authorPound, Susan
dc.contributor.authorMcauley, Sean
dc.contributor.authorRaghunathan, Senthil
dc.contributor.authorShelton, Faye
dc.contributor.authorHedstrom, Amanda
dc.contributor.authorGodfrey, Margi
dc.contributor.authorHavard, Diane
dc.contributor.authorBuck, Amanda
dc.contributor.authorKrishnan, Kailash
dc.contributor.authorGilzeane, Nicola
dc.contributor.authorRoffe, Jack
dc.contributor.authorClarke, Judith
dc.contributor.authorWhittamore, Katherine
dc.contributor.authorSheikh, Saima
dc.contributor.authorKeshvara, Rekha
dc.contributor.authorJordan, Carla
dc.contributor.authorJackson, Benjamin
dc.contributor.authorWilkes, Gwendoline
dc.contributor.authorAppleton, Jason
dc.contributor.authorLaw, Zhe
dc.contributor.authorMatias, Oliver
dc.contributor.authorVasileiadis, Evangelos
dc.contributor.authorMason, Cathy
dc.contributor.authorParry, Anthea
dc.contributor.authorLanders, Geraldine
dc.contributor.authorHolden, Melinda
dc.contributor.authorAweid, Basaam
dc.contributor.authorRashed, Khalid
dc.contributor.authorBalian, Linda
dc.contributor.authorVickers, Carinna
dc.contributor.authorKeeling, Elizabeth
dc.contributor.authorBoard, Sarah
dc.contributor.authorAllison, Joanna
dc.contributor.authorBuckley, Clare
dc.contributor.authorWilliams-Yesson, Barbara
dc.contributor.authorBoard, Joanne
dc.contributor.authorPitt-Kerby, Tressy
dc.contributor.authorTanate, Alfonso
dc.contributor.authorWood, Diane
dc.contributor.authorKini, Manohar
dc.contributor.authorChadha, Dinesh
dc.contributor.authorWalstow, Deborah
dc.contributor.authorFong, Rosanna
dc.contributor.authorLuder, Robert
dc.contributor.authorAdesina, Tolu
dc.contributor.authorGallagher, Jill
dc.contributor.authorBridger, Hayley
dc.contributor.authorMurali, Elodie
dc.contributor.authorBhargava, Maneesh
dc.contributor.authorvan Someren, Chloe
dc.contributor.authorHarrington, Frances
dc.contributor.authorMate, Abhijit
dc.contributor.authorJames, Ali
dc.contributor.authorCourtauld, Gillian
dc.contributor.authorSchofield, Christine
dc.contributor.authorAdie, Katja
dc.contributor.authorLucas, Linda
dc.contributor.authorBond, Kirsty
dc.contributor.authorMaund, Bev
dc.contributor.authorEllis, Sam
dc.contributor.authorMudd, Paul
dc.contributor.authorJames, Martin
dc.contributor.authorKeenan, Samantha
dc.contributor.authorBowring, Angela
dc.contributor.authorCageao, Julie
dc.contributor.authorKingwell, Hayley
dc.contributor.authorRoughan, Caroline
dc.contributor.authorHemsley, Anthony
dc.contributor.authorSword, Jane
dc.contributor.authorStrain, David
dc.contributor.authorMiller, Keniesha
dc.contributor.authorGoff, Anita
dc.contributor.authorGupwell, Karin
dc.contributor.authorThorpe, Kevin
dc.contributor.authorEmsley, Hedley
dc.contributor.authorPunekar, Shuja
dc.contributor.authorMcLoughlin, Alison
dc.contributor.authorSultan, Sulaiman
dc.contributor.authorGregory, Bindu
dc.contributor.authorRaj, Sonia
dc.contributor.authorDoyle, Donna
dc.contributor.authorMuir, Keith
dc.contributor.authorSmith, Wilma
dc.contributor.authorWelch, Angela
dc.contributor.authorMoreton, Fiona
dc.contributor.authorCheripelli, Bharath Kumar
dc.contributor.authorEl Tawil, Salwa
dc.contributor.authorKalladka, Dheeraj
dc.contributor.authorHuang, Xuya
dc.contributor.authorDay, Nicola
dc.contributor.authorRamachandran, Sankaranarayanan
dc.contributor.authorCrosbie, Caroline
dc.contributor.authorElliot, Jennifer
dc.contributor.authorRudd, Tony
dc.contributor.authorMarks, Katherine
dc.contributor.authorBhalla, Ajay
dc.contributor.authorBirns, Jonathan
dc.contributor.authorKullane, Sagal
dc.contributor.authorWeir, Nic
dc.contributor.authorAllen, Christopher
dc.contributor.authorPressly, Vanessa
dc.contributor.authorCrawford, Pam
dc.contributor.authorBattersby-Wood, Emma
dc.contributor.authorBlades, Alex
dc.contributor.authorEgerton, Shuna
dc.contributor.authorWalters, Ashleigh
dc.contributor.authorEvans, Sue
dc.contributor.authorMarigold, James Richard
dc.contributor.authorSmith, Fiona
dc.contributor.authorHoward, Gabriella
dc.contributor.authorGartrell, Imogen
dc.contributor.authorSmith, Simon
dc.contributor.authorCreeden, Robyn
dc.contributor.authorCox, Chloe
dc.contributor.authorBoxall, Cherish
dc.contributor.authorHewitt, Jonathan
dc.contributor.authorNott, Claire
dc.contributor.authorSarah, Procter
dc.contributor.authorWhiteman, Jessica
dc.contributor.authorBuckle, Steve
dc.contributor.authorWallace, Rebecca
dc.contributor.authorMardania, Rina
dc.contributor.authorGray, Jane
dc.contributor.authorTriscott, Claire
dc.contributor.authorNair, Anand
dc.contributor.authorGreig, Jill
dc.contributor.authorRana, Pratap
dc.contributor.authorRobinson, Matthew
dc.contributor.authorAlam, Mohammad Irfan
dc.contributor.authorWerring, David
dc.contributor.authorWilson, Duncan
dc.contributor.authorWatchurst, Caroline
dc.contributor.authorBrezitski, Maria
dc.contributor.authorCrook, Luci
dc.contributor.authorJones, Ifan
dc.contributor.authorBanaras, Azra
dc.contributor.authorPatel, Krishna
dc.contributor.authorErande, Renuka
dc.contributor.authorHogan, Caroline
dc.contributor.authorHostettler, Isabel
dc.contributor.authorAshton, Amy
dc.contributor.authorFeerick, Shez
dc.contributor.authorFrancia, Nina
dc.contributor.authorOji, Nnebuife
dc.contributor.authorElliott, Emma
dc.contributor.authorAl-Mayhani, Talal
dc.contributor.authorDennis, Martin
dc.contributor.authorSudlow, Cathie
dc.contributor.authorWhiteley, William
dc.contributor.authorDutta, Dipankar
dc.contributor.authorBrown, Pauline
dc.contributor.authorWard, Deborah
dc.contributor.authorDavis, Fiona
dc.contributor.authorTurfrey, Jennifer
dc.contributor.authorHughes, Chloe
dc.contributor.authorCollins, Kayleigh
dc.contributor.authorBakawala, Rehana
dc.contributor.authorO'Connell, Susan
dc.contributor.authorGlass, Jon
dc.contributor.authorBroughton, David
dc.contributor.authorTryambake, Dinesh
dc.contributor.authorDixon, Lynn
dc.contributor.authorChapman, Kath
dc.contributor.authorYoung, Andrew
dc.contributor.authorBergin, Adrian
dc.contributor.authorSigsworth, Andrew
dc.contributor.authorManoj, Aravind
dc.contributor.authorFletcher, Glyn
dc.contributor.authorLopez, Paula
dc.contributor.authorCox, Penelope
dc.contributor.authorWilkinson, Mark
dc.contributor.authorFitzsimmons, Paul
dc.contributor.authorSharma, Nikhil
dc.contributor.authorChoulerton, James
dc.contributor.authorButton, Denise
dc.contributor.authorDow, Lindsey
dc.contributor.authorGbadamoshi, Lukuman
dc.contributor.authorAvis, Joanne
dc.contributor.authorMadigan, Barbara
dc.contributor.authorMcCann, Stephanie
dc.contributor.authorShaw, Louise
dc.contributor.authorHowcroft, Deborah
dc.contributor.authorLucas, Suzanne
dc.contributor.authorStone, Andrew
dc.contributor.authorCluckie, Gillian
dc.contributor.authorLovelock, Caroline
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dc.contributor.authorChopra, Neha
dc.contributor.authorClarke, Natasha
dc.contributor.authorPatel, Bhavini
dc.contributor.authorKennedy, Kate
dc.contributor.authorWilliams, Rebecca
dc.contributor.authorBlight, Adrian
dc.contributor.authorO'Reilly, Joanna
dc.contributor.authorOrefo, Chukwuka
dc.contributor.authorDayal, Nilofer
dc.contributor.authorGhatala, Rita
dc.contributor.authorAdedoyin, Temi
dc.contributor.authorWatson, Fran
dc.contributor.authorTrippier, Sarah
dc.contributor.authorChoy, Lillian
dc.contributor.authorMoynihan, Barry
dc.contributor.authorKhan, Usman
dc.contributor.authorJones, Val
dc.contributor.authorJeyaraj, Naomi
dc.contributor.authorKerin, Lourda
dc.contributor.authorThavanesan, Kamy
dc.contributor.authorTiwari, Divya
dc.contributor.authorCox, Chantel
dc.contributor.authorLjubez, Anja
dc.contributor.authorTucker, Laura
dc.contributor.authorIqbal, Arshi
dc.contributor.authorBagnall, Caroline
dc.contributor.authorKeltos, Marketa
dc.contributor.authorRoberts, Josh
dc.contributor.authorJupp, Becky
dc.contributor.authorOvington, Catherine
dc.contributor.authorRogers, Emily
dc.contributor.authorDavid, Owen
dc.contributor.authorBell, Jo
dc.contributor.authorLongland, Barbara
dc.contributor.authorHann, Gail
dc.contributor.authorCooper, Martin
dc.contributor.authorNasar, Mohammad
dc.contributor.authorRajapakse, Anoja
dc.contributor.authorWynter, Inez
dc.contributor.authorAnwar, Ijaz
dc.contributor.authorSkinner, Helen
dc.contributor.authorNozedar, Tarn
dc.contributor.authorMcArdle, Damian
dc.contributor.authorKumar, Balakrishna
dc.contributor.authorCrawford, Susan
dc.contributor.authorAnnamalai, Arunkumar
dc.contributor.authorRamshaw, Alex
dc.contributor.authorHolmes, Clare
dc.contributor.authorCaine, Sarah
dc.contributor.authorOsborn, Mairead
dc.contributor.authorDodd, Emily
dc.contributor.authorMurphy, Peter
dc.contributor.authorDevitt, Nicola
dc.contributor.authorBaker, Pauline
dc.contributor.authorSteele, Amy
dc.contributor.authorGuthrie, Lucy Belle
dc.contributor.authorClarke, Samantha
dc.contributor.authorHassan, Ahamad
dc.contributor.authorWaugh, Dean
dc.contributor.authorVeraque, Emelda
dc.contributor.authorMakawa, Linetty
dc.contributor.authorKambafwile, Mary
dc.contributor.authorRandall, Marc
dc.contributor.authorPapavasileiou, Vasileios
dc.contributor.authorCullen, Claire
dc.contributor.authorPeters, Jenny
dc.contributor.authorThant, Hlaing
dc.contributor.authorIngram, Tanya
dc.contributor.authorZoe, Mellor
dc.contributor.authorDurairaj, Ramesh
dc.contributor.authorHarrison, Melanie
dc.contributor.authorStevenson, Sarah
dc.contributor.authorShackcloth, Daniela
dc.contributor.authorEwing, Jordan
dc.contributor.authorSutton, Victoria
dc.contributor.authorMcCarron, Mark
dc.contributor.authorMcKee, Jacqueline
dc.contributor.authorDoherty, Mandy
dc.contributor.authorMcVerry, Ferghal
dc.contributor.authorBlair, Caroline
dc.contributor.authorMacLeod, Mary
dc.contributor.authorIrvine, Janice
dc.contributor.authorGow, Heather
dc.contributor.authorFurnace, Jacqueline
dc.contributor.authorJoyson, Anu
dc.contributor.authorJagpal, Baljit
dc.contributor.authorRoss, Sarah
dc.contributor.authorKlaasen, Katrina
dc.contributor.authorNelson, Sandra
dc.contributor.authorClarke, Rebecca
dc.contributor.authorCrouch, Nichola
dc.contributor.authorMacLennan, Beverly
dc.contributor.authorTaylor, Vicky
dc.contributor.authorEpstein, Daniel
dc.contributor.authorShukla, Avani
dc.contributor.authorKrishnamurthy, Vinodh
dc.contributor.authorNicholas, Paul
dc.contributor.authorQureshi, Sammie
dc.contributor.authorWebber, Adam
dc.contributor.authorPenge, Justin
dc.contributor.authorRamadan, Hawraman
dc.contributor.authorMaguire, Stuart
dc.contributor.authorPatterson, Chris
dc.contributor.authorBellfield, Ruth
dc.contributor.authorHairsine, Brigid
dc.contributor.authorStewart, Kelvin
dc.contributor.authorHooley, Michaela
dc.contributor.authorQuinn, Outi
dc.contributor.authorRichard, Bella
dc.contributor.authorMoseley, Sally
dc.contributor.authorEdwards, Mandy
dc.contributor.authorLawson, Heidi
dc.contributor.authorTayler, Michelle
dc.contributor.authorPai, Yogish
dc.contributor.authorDhakal, Mahesh
dc.contributor.authorEsisi, Bernard
dc.contributor.authorDima, Sofia
dc.contributor.authorSmith, Gemma Marie
dc.contributor.authorGarside, Mark
dc.contributor.authorNaeem, Muhammad
dc.contributor.authorBaliga, Vidya
dc.contributor.authorRogers, Gill
dc.contributor.authorBrown, Ellen
dc.contributor.authorBruce, David
dc.contributor.authorHayman, Rachel
dc.contributor.authorClayton, Susan
dc.contributor.authorGamble, Ed
dc.contributor.authorGrue, Rebecca
dc.contributor.authorCharles, Bethan
dc.contributor.authorHague, Adam
dc.contributor.authorBlane, Sujata
dc.contributor.authorLambert, Caroline
dc.contributor.authorChaudhry, Afnan
dc.contributor.authorHarrison, Thomas
dc.contributor.authorSaastamoinen, Kari
dc.contributor.authorHove, Dionne
dc.contributor.authorHowaniec, Laura
dc.contributor.authorGrimwood, Gemma
dc.contributor.authorRedjep, Ozlem
dc.contributor.authorHumphries, Fiona
dc.contributor.authorArgandona, Lucia
dc.contributor.authorCuenoud, Larissa
dc.contributor.authorErumere, Esther
dc.contributor.authorAmlani, Sageet
dc.contributor.authorAuld, Grace
dc.contributor.authorSalek-Haddadi, Afraim
dc.contributor.authorSchulz, Ursula
dc.contributor.authorKennedy, James
dc.contributor.authorFord, Gary
dc.contributor.authorMathieson, Philip
dc.contributor.authorReckless, Ian
dc.contributor.authorTeal, Rachel
dc.contributor.authorLenti, Giulia
dc.contributor.authorHarston, George
dc.contributor.authorO'Brien, Eoin
dc.contributor.authorMcgee, Joanne
dc.contributor.authorMitchell, Jennifer
dc.contributor.authorAmis, Elaine
dc.contributor.authorHandley, Dominic
dc.contributor.authorKelly, Siobhan
dc.contributor.authorZachariah, George
dc.contributor.authorFrancis, Jobbin
dc.contributor.authorCrisp, Sarah
dc.contributor.authorSesay, Juliana
dc.contributor.authorFinlay, Sarah
dc.contributor.authorHayhoe, Helen
dc.contributor.authorHannon, Niamh
dc.contributor.authorHughes, Tom
dc.contributor.authorMorse, Bethan
dc.contributor.authorDe Berker, Henry
dc.contributor.authorTallantyre, Emma
dc.contributor.authorOsman, Ahmed
dc.contributor.authorWhite, Susan
dc.contributor.authorSchwarz, Stefan
dc.contributor.authorJelley, Benjamin
dc.contributor.authorYadava, Rajendra
dc.contributor.authorAzhar, Khalid
dc.contributor.authorReddan, Julie
dc.contributor.authorSangombe, Mirriam
dc.contributor.authorStafford, Samantha
dc.contributor.authorFotherby, Ken
dc.contributor.authorMorgan, Debbie
dc.contributor.authorBaig, Farrukh
dc.contributor.authorJennings-Preece, Karla
dc.contributor.authorButler, Donna
dc.contributor.authorAhmad, Nasar
dc.contributor.authorWillberry, Angela
dc.contributor.authorStevens, Angela
dc.contributor.authorRai, Baljinder
dc.contributor.authorSiddegowda, Prasad
dc.contributor.authorHoward, Peter
dc.contributor.authorHyatt, Lisa
dc.contributor.authorDobson, Tracey
dc.contributor.authorJarrett, David
dc.contributor.authorPonnambath, Suheil
dc.contributor.authorTandy, Jane
dc.contributor.authorHarrington-Davies, Yasmin
dc.contributor.authorButler, Rebecca
dc.contributor.authorJames, Claire
dc.contributor.authorValentine, Stacey
dc.contributor.authorSuttling, Anne
dc.contributor.authorLanghorne, Peter
dc.contributor.authorKerr, Gillian
dc.contributor.authorWright, Fiona
dc.contributor.authorGraham, Ruth
dc.contributor.authorMcAlpine, Christine
dc.contributor.authorIqbal, Mohammad Shahzad
dc.contributor.authorHumphreys, Louise
dc.contributor.authorPasco, Kath
dc.contributor.authorBalazikova, Olga
dc.contributor.authorNasim, Ashraf
dc.contributor.authorPeixoto, Cassilda
dc.contributor.authorGallagher, Louise
dc.contributor.authorShahmehri, Shahrzad
dc.contributor.authorGhosh, Sandip
dc.contributor.authorBarrie, Elizabeth
dc.contributor.authorGilmour, Danielle
dc.contributor.authorHenry, Margo
dc.contributor.authorWebb, Tom
dc.contributor.authorCowie, Linda
dc.contributor.authorRudenko, Hannah
dc.contributor.authorMcDonald, Shanni
dc.contributor.authorSchumacher, Natasha
dc.contributor.authorWalker, Susannah
dc.contributor.authorCosier, Tracey
dc.contributor.authorVerrion, Anna
dc.contributor.authorBeranova, Eva
dc.contributor.authorThomson, Audrey
dc.contributor.authorVenter, Marius
dc.contributor.authorKar, Arindam
dc.contributor.authorMashate, Sheila
dc.contributor.authorHarvey, Kirsten
dc.contributor.authorGardener, Léjeune
dc.contributor.authorNguyen, Vinh
dc.contributor.authorHalse, Omid
dc.contributor.authorGeraghty, Olivia
dc.contributor.authorHazel, Beth
dc.contributor.authorWilding, Peter
dc.contributor.authorTilley, Victoria
dc.contributor.authorCassidy, Tim
dc.contributor.authorMcClelland, Beverley
dc.contributor.authorBokhari, Maria
dc.contributor.authorEngland, Timothy
dc.contributor.authorMaddula, Mohana
dc.contributor.authorDonnelly, Richard
dc.contributor.authorFindlay, Paul
dc.contributor.authorMacaden, Ashish
dc.contributor.authorShread, Ian
dc.contributor.authorBarr, Charlotte
dc.contributor.authorMohd Nor, Azlisham
dc.contributor.authorBrown, Claire
dc.contributor.authorPersad, Nicola
dc.contributor.authorEglinton, Charlotte
dc.contributor.authorWeinling, Marie
dc.contributor.authorHyams, Benjamin
dc.contributor.authorShah, Alex
dc.contributor.authorBaker, John
dc.contributor.authorByrne, Anthony
dc.contributor.authorMcGhee, Caroline
dc.contributor.authorSmart, Amanda
dc.contributor.authorCopeland, Claire
dc.contributor.authorCarpenter, Michael
dc.contributor.authorWalker, Marion
dc.contributor.authorDavey, Richard
dc.contributor.authorNeedle, Ann
dc.contributor.authorFathima, Razik
dc.contributor.authorBateman, Gavin
dc.contributor.authorDatta, Prabal
dc.contributor.authorStanners, Andrew
dc.contributor.authorJackson, Linda
dc.contributor.authorBall, Julie
dc.contributor.authorDavis, Michelle
dc.contributor.authorAtkinson, Natalie
dc.contributor.authorFawcett, Michelle
dc.contributor.authorThompson, Teresa
dc.contributor.authorGuy, Helen
dc.contributor.authorHogg, Valerie
dc.contributor.authorHays, Carole
dc.contributor.authorWoodward, Stephen
dc.contributor.authorHaque, Mohammad
dc.contributor.authorHakim, Eluzai
dc.contributor.authorSymonds, Stuart
dc.contributor.authorMaanoosi, Mehran
dc.contributor.authorHerman, Jane
dc.contributor.authorBlack, Toby
dc.contributor.authorMiriam, Skelton
dc.contributor.authorClarke, Caroline
dc.contributor.authorAnthony, Alpha
dc.contributor.authorTribbeck, Michele
dc.contributor.authorCronin, Julie
dc.contributor.authorMead, Denise
dc.contributor.authorFennelly, Ruth
dc.contributor.authorMcIlmoyle, James
dc.contributor.authorDickinson, Christina
dc.contributor.authorJeffs, Carol
dc.contributor.authorAnwar, Sajjad
dc.contributor.authorHoward, Joanne
dc.contributor.authorJones, Kirsty
dc.contributor.authorDhar, Saikat
dc.contributor.authorClay, Caroline
dc.contributor.authorSiddiq, Muhammad
dc.contributor.authorIvatts, Simone
dc.contributor.authorBaird, Yolanda
dc.contributor.authorSally, Moore
dc.contributor.authorAmey, Isobel
dc.contributor.authorNewton, Sophie
dc.contributor.authorClayton-Evans, Lisa
dc.contributor.authorChadbourn, Indra
dc.contributor.authorRayessa, Rayessa
dc.contributor.authorNaylor, Charde
dc.contributor.authorRodgers, Alicia
dc.contributor.authorWilson, Lisa
dc.contributor.authorWilson, Sarah
dc.contributor.authorClarkson, Emma
dc.contributor.authorDavies, Ruth
dc.contributor.authorOwings, Paula
dc.contributor.authorSangster, Graeme
dc.contributor.authorGott, Valerie
dc.contributor.authorLittle, Victoria
dc.contributor.authorWeir, Pauline
dc.contributor.authorCherian, Suja
dc.contributor.authorJose, Deepa
dc.contributor.authorMoroney, Helen
dc.contributor.authorDownham, Susan
dc.contributor.authorDodd, Angela
dc.contributor.authorVettimootal Johnson, Venetia
dc.contributor.authorCodd, Laura
dc.contributor.authorRobinson, Naomi
dc.contributor.authorAhmed, Ashraf
dc.contributor.authorAlbazzaz, Mo
dc.contributor.authorJohnson, Sharon
dc.contributor.authorDenniss, Carol
dc.contributor.authorCunningham, Mishell
dc.contributor.authorZahoor, Tajammal
dc.contributor.authorWebster, Timothy
dc.contributor.authorLeason, Sandra
dc.contributor.authorHaider, Syed
dc.contributor.authorChatterjee, Kausic
dc.contributor.authorNallasivan, Arumugam
dc.contributor.authorPerkins, Charlotte
dc.contributor.authorSeagrave, Samantha
dc.contributor.authorJenkins, Colin
dc.contributor.authorPrice, Fiona
dc.contributor.authorHughes, Claire
dc.contributor.authorMercer, Lily
dc.contributor.authorHussain, Malik
dc.contributor.authorBrown, Sarah
dc.contributor.authorHarvey, Miriam
dc.contributor.authorHoman, Jane
dc.contributor.authorKhan, Mohammad
dc.contributor.authorWhiting, Robert
dc.contributor.authorFoote, Leanne
dc.contributor.authorHunt, Nicholas
dc.contributor.authorDurman, Helen
dc.contributor.authorBrotherton, Lucy
dc.contributor.authorFoot, Jayne
dc.contributor.authorPawley, Corinne
dc.contributor.authorFoster, Eliza
dc.contributor.authorWhitcher, Alison
dc.contributor.authorMetcalf, Kneale
dc.contributor.authorJagger, Jenny
dc.contributor.authorMcDonald, Susan
dc.contributor.authorWaterfield, Kelly
dc.contributor.authorSutton, Patrick
dc.contributor.authorShinh, Naval
dc.contributor.authorAnversha, Ajmal
dc.contributor.authorRavenhill, Garth
dc.contributor.authorGreenwood, Richard
dc.contributor.authorSaada, Janak
dc.contributor.authorWiltshire, Alison
dc.contributor.authorPerfitt, Rebekah
dc.contributor.authorAndole, Sreeman
dc.contributor.authorGadapa, Naveen
dc.contributor.authorDunne, Karen
dc.contributor.authorKrommyda, Magdalini
dc.contributor.authorBurssens, Evelyne
dc.contributor.authorKing, Sam
dc.contributor.authorPlewa, Catherine
dc.contributor.authorSmyth, Nigel
dc.contributor.authorWilson, Jenny
dc.contributor.authorGiallombardo, Elio
dc.contributor.authorSykes, Lucy
dc.contributor.authorKumar, Pradeep
dc.contributor.authorBarker, James
dc.contributor.authorHuggett, Isabel
dc.contributor.authorDunn, Linda
dc.contributor.authorCulmsee, Charlotte
dc.contributor.authorThomas, Philip
dc.contributor.authorMyint, Min
dc.contributor.authorBrew, Helen
dc.contributor.authorMajmudar, Nikhil
dc.contributor.authorOConnell, Janice
dc.contributor.authorBunea, George
dc.contributor.authorFox, Charlotte
dc.contributor.authorGulliver, Diane
dc.contributor.authorSmith, Andrew
dc.contributor.authorMokoena, Betty
dc.contributor.authorSattar, Naweed
dc.contributor.authorKrishnamurthy, Ramesh
dc.contributor.authorOsborne, Emily
dc.contributor.authorWilson, David
dc.contributor.authorWroath, Belinda
dc.contributor.authorDynan, Kevin
dc.contributor.authorPower, Michael
dc.contributor.authorThompson, Susan
dc.contributor.authorAdell, Victoria
dc.contributor.authorOrugun, Enoch
dc.contributor.authorPoultney, Una
dc.contributor.authorGlover, Rachel
dc.contributor.authorCrowther, Hannah
dc.contributor.authorThornthwaite, Sarah
dc.contributor.authorWiggam, Ivan
dc.contributor.authorWallace, Aine
dc.contributor.authorKerr, Enda
dc.contributor.authorFulton, Ailsa
dc.contributor.authorHunter, Annemarie
dc.contributor.authorTauro, Suzanne
dc.contributor.authorCuddy, Sarah
dc.contributor.authorMangion, David
dc.contributor.authorHardwick, Anne
dc.contributor.authorMarkova, Skarlet
dc.contributor.authorLawrence, Tara
dc.contributor.authorConstantin, Carmen
dc.contributor.authorFletcher, Jo
dc.contributor.authorThomas, Isobel
dc.contributor.authorPettitt, Kerry
dc.contributor.authorSekaran, Lakshmanan
dc.contributor.authorTate, Margaret
dc.contributor.authorBharaj, Kiranjit
dc.contributor.authorSimon, Rohan
dc.contributor.authorJustin, Frances
dc.contributor.authorSethuraman, Sakthivel
dc.contributor.authorPhiri, Duke
dc.contributor.authorMohammed, Niaz
dc.contributor.authorChauhan, Meena
dc.contributor.authorElfandi, Khaled
dc.contributor.authorKhan, Uzma
dc.contributor.authorEveson, David
dc.contributor.authorMistri, Amit
dc.contributor.authorManning, Lisa
dc.contributor.authorKhan, Shagufta
dc.contributor.authorPatel, Champa
dc.contributor.authorMoqsith, Mohammed
dc.contributor.authorSattar, Saira
dc.contributor.authorLam, Man Yee
dc.contributor.authorMusarrat, Kashif
dc.contributor.authorStephens, Claire
dc.contributor.authorKalathil, Latheef
dc.contributor.authorMiller, Richard
dc.contributor.authorSalehin, Maqsud
dc.contributor.authorGautam, Nikki
dc.contributor.authorBailey, Duncan
dc.contributor.authorAmor, Kelly
dc.contributor.authorMeir, Julie
dc.contributor.authorNicolson, Anne
dc.contributor.authorImam, Javed
dc.contributor.authorWood, Lisa
dc.contributor.authorWhite, Julie
dc.contributor.authorSajid, Mahmud
dc.contributor.authorGhaly, George
dc.contributor.authorBall, Margaret
dc.contributor.authorGascoyne, Rachel
dc.contributor.authorProeschel, Harald
dc.contributor.authorSharpe, Simon
dc.contributor.authorHorton, Sarah
dc.contributor.authorBeaves, Emily
dc.contributor.authorJones, Stephanie
dc.contributor.authorYip, Brigitte
dc.contributor.authorBell, Murdina
dc.contributor.authorMacLiver, Linda
dc.contributor.authorMacInnes, Brian
dc.contributor.authorSims, Don
dc.contributor.authorHurley, Jennifer
dc.contributor.authorWillmot, Mark
dc.contributor.authorSutton, Claire
dc.contributor.authorLittleton, Edward
dc.contributor.authorMaiden, Susan
dc.contributor.authorJones, Rachael
dc.contributor.authorCunningham, James
dc.contributor.authorGreen, Carole
dc.contributor.authorBates, Michelle
dc.contributor.authorShekhar, Raj
dc.contributor.authorGilham, Ellie
dc.contributor.authorAhmed, Iman
dc.contributor.authorCrown, Rachel
dc.contributor.authorFuller, Tracy
dc.contributor.authorGoorah, Neetish
dc.contributor.authorBell, Angela
dc.contributor.authorKelly, Christine
dc.contributor.authorSingh, Arun
dc.contributor.authorWalford, Jamie
dc.contributor.authorTomlinson, Benjamin
dc.contributor.authorPatel, Farzana
dc.contributor.authorDuberley, Stephen
dc.contributor.authorKane, Ingrid
dc.contributor.authorRajkumar, Chakravarthi
dc.contributor.authorGaylard, Jane
dc.contributor.authorBreeds, Joanna
dc.contributor.authorGainsborough, Nicola
dc.contributor.authorPitt-Ford, Alexandra
dc.contributor.authorBarbon, Emma
dc.contributor.authorLatter, Laura
dc.contributor.authorThompson, Philip
dc.contributor.authorHervey, Simon
dc.contributor.authorKrishnamoorthy, Shrivakumar
dc.contributor.authorVassallo, Joseph
dc.contributor.authorWalter, Deborah
dc.contributor.authorCochrane, Helen
dc.contributor.authorSrinivasan, Meena
dc.contributor.authorCampbell, Robert
dc.contributor.authorDonaldson, Denise
dc.contributor.authorMotherwell, Nichola
dc.contributor.authorHurford, Frances
dc.contributor.authorMukherjee, Indranil
dc.contributor.authorKenton, Antony
dc.contributor.authorNyabadza, Sheila
dc.contributor.authorMartin, Irene
dc.contributor.authorHunt, Benjamin
dc.contributor.authorHassan, Hardi
dc.contributor.authorO'Toole, Sarah
dc.contributor.authorDallol, Bander
dc.contributor.authorPutterill, Janet
dc.contributor.authorJha, Ratneshwari
dc.contributor.authorGallifent, Rachel
dc.contributor.authorKakar, Puneet
dc.contributor.authorPusalkar, Aparna
dc.contributor.authorChan, kelly
dc.contributor.authorDangri, Puneet
dc.contributor.authorBeadle, Hannah
dc.contributor.authorCook, Angela
dc.contributor.authorCrabtree, Karen
dc.contributor.authorSubramonian, Santhosh
dc.contributor.authorOwusu-Agyei, Peter
dc.contributor.authorTemple, Natalie
dc.contributor.authorButterworth-Cowin, Nicola
dc.contributor.authorRagab, Suzanne
dc.contributor.authorKnops, Kerstin
dc.contributor.authorJinks, Emma
dc.contributor.authorDickson, Christine
dc.contributor.authorGleave, Laura
dc.contributor.authorDube, Judith
dc.contributor.authorLeggett, Jacqui
dc.contributor.authorGarcia, Tatiana
dc.contributor.authorIspoglou, Sissy
dc.contributor.authorEvans, Rachel
dc.contributor.authorAnkolekar, Sandeep
dc.contributor.authorHayes, Anne
dc.contributor.authorNi, Hlaing
dc.contributor.authorRahman, Bithi
dc.contributor.authorMilligan, Josette
dc.contributor.authorGraham, Carol
dc.contributor.authorJose, Josin
dc.contributor.authorKeegan, Breffni
dc.contributor.authorKelly, Jim
dc.contributor.authorDewar, Richard
dc.contributor.authorWhite, James
dc.contributor.authorThomas, Kelly
dc.date.accessioned2020-09-21T16:30:04Z
dc.date.available2020-09-21T16:30:04Z
dc.date.issued2019-07-01
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J , Gainsborough , N , Pitt-Ford , A , Barbon , E , Latter , L , Thompson , P , Hervey , S , Krishnamoorthy , S , Vassallo , J , Walter , D , Cochrane , H , Srinivasan , M , Campbell , R , Donaldson , D , Motherwell , N , Hurford , F , Mukherjee , I , Kenton , A , Nyabadza , S , Martin , I , Hunt , B , Hassan , H , O'Toole , S , Dallol , B , Putterill , J , Jha , R , Gallifent , R , Kakar , P , Pusalkar , A , Chan , K , Dangri , P , Beadle , H , Cook , A , Crabtree , K , Subramonian , S , Owusu-Agyei , P , Temple , N , Butterworth-Cowin , N , Ragab , S , Knops , K , Jinks , E , Dickson , C , Gleave , L , Dube , J , Leggett , J , Garcia , T , Ispoglou , S , Evans , R , Ankolekar , S , Hayes , A , Ni , H , Rahman , B , Milligan , J , Graham , C , Jose , J , Keegan , B , Kelly , J , Dewar , R , White , J & Thomas , K 2019 , ' Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases : subgroup analyses of the RESTART randomised, open-label trial ' , The Lancet Neurology , vol. 18 , no. 7 , pp. 643-652 . https://doi.org/10.1016/S1474-4422(19)30184-Xen
dc.identifier.issn1474-4422
dc.identifier.otherPURE: 267715680
dc.identifier.otherPURE UUID: 3eb1e54e-5df3-41c7-a731-d8bf166ddbbc
dc.identifier.otherScopus: 85067016486
dc.identifier.otherPubMed: 31129065
dc.identifier.otherORCID: /0000-0002-2104-7313/work/73700693
dc.identifier.urihttp://hdl.handle.net/10023/20660
dc.descriptionFunding: British Heart Foundation Special Project Grant SP/12/2/20422.en
dc.description.abstractBackground : Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy. Methods : RESTART was a prospective, randomised, open-label, blinded-endpoint, parallel-group trial at 122 hospitals in the UK that assessed whether starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. For this prespecified subgroup analysis, consultant neuroradiologists masked to treatment allocation reviewed brain CT or MRI scans performed before randomisation to confirm participant eligibility and rate features of the intracerebral haemorrhage and surrounding brain. We followed participants for primary (recurrent symptomatic intracerebral haemorrhage) and secondary (ischaemic stroke) outcomes for up to 5 years (reported elsewhere). For this report, we analysed eligible participants with intracerebral haemorrhage according to their treatment allocation in primary subgroup analyses of cerebral microbleeds on MRI and in exploratory subgroup analyses of other features on CT or MRI. The trial is registered with the ISRCTN registry, number ISRCTN71907627. Findings : Between May 22, 2013, and May 31, 2018, 537 participants were enrolled, of whom 525 (98%) had intracerebral haemorrhage: 507 (97%) were diagnosed on CT (252 assigned to start antiplatelet therapy and 255 assigned to avoid antiplatelet therapy, of whom one withdrew and was not analysed) and 254 (48%) underwent the required brain MRI protocol (122 in the start antiplatelet therapy group and 132 in the avoid antiplatelet therapy group). There were no clinically or statistically significant hazards of antiplatelet therapy on recurrent intracerebral haemorrhage in primary subgroup analyses of cerebral microbleed presence (2 or more) versus absence (0 or 1) (adjusted hazard ratio [HR] 0·30 [95% CI 0·08–1·13] vs 0·77 [0·13–4·61]; pinteraction=0·41), cerebral microbleed number 0–1 versus 2–4 versus 5 or more (HR 0·77 [0·13–4·62] vs 0·32 [0·03–3·66] vs 0·33 [0·07–1·60]; pinteraction=0·75), or cerebral microbleed strictly lobar versus other location (HR 0·52 [0·004–6·79] vs 0·37 [0·09–1·28]; pinteraction=0·85). There was no evidence of heterogeneity in the effects of antiplatelet therapy in any exploratory subgroup analyses (all pinteraction>0·05). Interpretation : Our findings exclude all but a very modest harmful effect of antiplatelet therapy on recurrent intracerebral haemorrhage in the presence of cerebral microbleeds. Further randomised trials are needed to replicate these findings and investigate them with greater precision. Funding: British Heart Foundation.
dc.format.extent10
dc.language.isoeng
dc.relation.ispartofThe Lancet Neurologyen
dc.rightsCopyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.en
dc.subjectClinical Neurologyen
dc.subjectDASen
dc.titleEffects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases : subgroup analyses of the RESTART randomised, open-label trialen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews.Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews.Pure Mathematicsen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.identifier.doihttps://doi.org/10.1016/S1474-4422(19)30184-X
dc.description.statusPeer revieweden


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