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dc.contributor.authorHodgson, Amy
dc.contributor.authorRichmond, Claire
dc.contributor.authorTello, Javier
dc.contributor.authorBrown, Gillian R.
dc.date.accessioned2020-09-16T08:31:04Z
dc.date.available2020-09-16T08:31:04Z
dc.date.issued2020-09
dc.identifier.citationHodgson , A , Richmond , C , Tello , J & Brown , G R 2020 , ' Suppression of ovarian hormones in adolescent rats has no effect on anxiety-like behaviour or c-fos activation in the amygdala ' , Journal of Neuroendocrinology , vol. 32 , no. 9 , e12897 . https://doi.org/10.1111/jne.12897en
dc.identifier.issn1365-2826
dc.identifier.otherPURE: 269365870
dc.identifier.otherPURE UUID: f9e11b29-fc9c-455e-8013-5ca958502dfa
dc.identifier.otherORCID: /0000-0002-0675-0780/work/80620102
dc.identifier.otherORCID: /0000-0001-6637-2155/work/80620307
dc.identifier.otherScopus: 85090979523
dc.identifier.urihttp://hdl.handle.net/10023/20628
dc.descriptionSupport was provided the British Society for Neuroendocrinology, Carnegie Trust for the Universities of Scotland and School of Psychology & Neuroscience, University of St Andrews.en
dc.description.abstractIn humans, sex differences in mood disorders emerge during adolescence, with prevalence rates being consistently higher in females than males. It has been hypothesised that exposure to endogenous ovarian hormones during adolescence enhances the susceptibility of females to mood disorders from this stage of life onwards. However, experimental evidence in favour of this hypothesis is lacking. In the present study, we examined the long‐term effects of suppressing adolescent gonadal hormone levels in a group of female Lister‐hooded rats via administration of a gonadotrophin‐releasing hormone antagonist (Antide; administered on postnatal day [PND] 28 and 42) compared to control females and males (n = 14 per group). We predicted that, in adulthood, Antide‐treated female rats would exhibit more male‐like behaviour than control females in novel environments (elevated‐plus maze, open field and light‐dark box), in response to novel objects and novel social partners, and in an acoustic startle task. Progesterone and luteinising hormone assays (which were conducted on blood samples collected on PND 55/56 and 69/70) confirmed that the hypothalamic‐pituitary‐gonadal axis was temporarily suppressed by Antide treatment. In addition, Antide‐treated females were found to exhibit a modest pubertal delay, as measured by vaginal opening, which was comparable in length to the pubertal delay that has been induced by adolescent exposure to alcohol or stress in previous studies of female rats. However, Antide‐treated females did not substantially differ from control females on any of the behavioural tests, despite the evidence for predicted sex differences in some measures. Following the acoustic startle response task, all subjects were culled and perfused, and c‐Fos staining was conducted in the medial and basolateral amygdala, with the results showing no significant differences in cell counts between the groups. These findings suggest that ovarian hormone exposure during adolescence does not have long‐term effects on anxiety‐related responses in female rats.
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofJournal of Neuroendocrinologyen
dc.rightsCopyright © 2020 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectPubertyen
dc.subjectAntideen
dc.subjectSex differenceen
dc.subjectProgesteroneen
dc.subjectLHen
dc.subjectBF Psychologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subject.lccBFen
dc.subject.lccRC0321en
dc.titleSuppression of ovarian hormones in adolescent rats has no effect on anxiety-like behaviour or c-fos activation in the amygdalaen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.Centre for Biophotonicsen
dc.contributor.institutionUniversity of St Andrews.Cellular Medicine Divisionen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Centre for Research into Equality, Diversity & Inclusionen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews.Centre for Social Learning & Cognitive Evolutionen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.identifier.doihttps://doi.org/10.1111/jne.12897
dc.description.statusPeer revieweden
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/jne.12897#support-information-sectionen


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