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dc.contributor.authorTorres-Aguila, Nuria P
dc.contributor.authorCarrera, Caty
dc.contributor.authorMuiño, Elena
dc.contributor.authorCullell, Natalia
dc.contributor.authorCárcel-Márquez, Jara
dc.contributor.authorGallego-Fabrega, Cristina
dc.contributor.authorGonzález-Sánchez, Jonathan
dc.contributor.authorBustamante, Alejandro
dc.contributor.authorDelgado, Pilar
dc.contributor.authorIbañez, Laura
dc.contributor.authorHeitsch, Laura
dc.contributor.authorKrupinski, Jerzy
dc.contributor.authorMontaner, Joan
dc.contributor.authorMartí-Fàbregas, Joan
dc.contributor.authorCruchaga, Carlos
dc.contributor.authorLee, Jin-Moo
dc.contributor.authorFernandez-Cadenas, Israel
dc.contributor.authorAcute Endophenotypes Group of the International Stroke Genetics Consortium (ISGC)
dc.date.accessioned2020-07-29T15:30:03Z
dc.date.available2020-07-29T15:30:03Z
dc.date.issued2019-09
dc.identifier.citationTorres-Aguila , N P , Carrera , C , Muiño , E , Cullell , N , Cárcel-Márquez , J , Gallego-Fabrega , C , González-Sánchez , J , Bustamante , A , Delgado , P , Ibañez , L , Heitsch , L , Krupinski , J , Montaner , J , Martí-Fàbregas , J , Cruchaga , C , Lee , J-M , Fernandez-Cadenas , I & Acute Endophenotypes Group of the International Stroke Genetics Consortium (ISGC) 2019 , ' Clinical variables and genetic risk factors associated with the acute outcome of ischemic stroke : a systematic review ' , Stroke , vol. 21 , no. 3 , pp. 276-289 . https://doi.org/10.5853/jos.2019.01522en
dc.identifier.issn2287-6391
dc.identifier.otherPURE: 269343901
dc.identifier.otherPURE UUID: e7a7ff7e-b993-4d80-b989-15af41d35c5a
dc.identifier.otherPubMed: 31590472
dc.identifier.otherPubMedCentral: PMC6780022
dc.identifier.otherScopus: 85073470165
dc.identifier.urihttp://hdl.handle.net/10023/20367
dc.description.abstractStroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. In this review, we expound what is known about the influence of clinical variables and related genetic risk factors on ischemic stroke outcome, focusing on acute and subacute outcome (within 24 to 48 hours after stroke and until day 10, respectively), as they are the first indicators of stroke damage. We searched the PubMed data base for articles that investigated the interaction between clinical variables or genetic factors and acute or subacute stroke outcome. A total of 61 studies were finally included in this review. Regarding the data collected, the variables consistently associated with acute stroke outcome are: glucose levels, blood pressure, presence of atrial fibrillation, prior statin treatment, stroke severity, type of acute treatment performed, severe neurological complications, leukocyte levels, and genetic risk factors. Further research and international efforts are required in this field, which should include genome-wide association studies.
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofStrokeen
dc.rightsCopyright © 2019 Korean Stroke Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectQH426 Geneticsen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subject.lccQH426en
dc.subject.lccRC0321en
dc.titleClinical variables and genetic risk factors associated with the acute outcome of ischemic stroke : a systematic reviewen
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.identifier.doihttps://doi.org/10.5853/jos.2019.01522
dc.description.statusPeer revieweden


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