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An enzymatic Finkelstein reaction : fluorinase catalyses direct halogen exchange
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dc.contributor.author | Lowe, Phillip T. | |
dc.contributor.author | Cobb, Steven L. | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2020-07-24T23:36:06Z | |
dc.date.available | 2020-07-24T23:36:06Z | |
dc.date.issued | 2019-08-28 | |
dc.identifier | 260859368 | |
dc.identifier | bc325925-d178-42c1-8535-efe9679f7c61 | |
dc.identifier | 85070705601 | |
dc.identifier | 000481416200008 | |
dc.identifier.citation | Lowe , P T , Cobb , S L & O'Hagan , D 2019 , ' An enzymatic Finkelstein reaction : fluorinase catalyses direct halogen exchange ' , Organic & Biomolecular Chemistry , vol. 17 , no. 32 , pp. 7493-7496 . https://doi.org/10.1039/C9OB01625B | en |
dc.identifier.issn | 1477-0520 | |
dc.identifier.other | Bibtex: urn:f31175a170f124ab5f3933a18eca40d9 | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/68281291 | |
dc.identifier.other | ORCID: /0000-0003-1568-0750/work/122719953 | |
dc.identifier.uri | https://hdl.handle.net/10023/20336 | |
dc.description | We thank the Engineering and Physical Sciences Research Council, UK, for a research grant. | en |
dc.description.abstract | The fluorinase enzyme from Streptomyces cattleya is shown to catalyse a direct displacement of bromide and iodide by fluoride ion from 5′-bromodeoxyadenosine (5′-BrDA) and 5′-iododeoxyadenosine (5′-IDA) respectively to form 5′-fluorodeoxyadenosine (5′-FDA) in the absence of L-methionine (L-Met) or S-adenosyl-L-methionine (SAM). 5′-BrDA is the most efficient substrate for this enzyme catalysed Finkelstein reaction. | |
dc.format.extent | 4 | |
dc.format.extent | 626327 | |
dc.language.iso | eng | |
dc.relation.ispartof | Organic & Biomolecular Chemistry | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.title | An enzymatic Finkelstein reaction : fluorinase catalyses direct halogen exchange | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | https://doi.org/10.1039/C9OB01625B | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2020-07-25 |
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