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An enzymatic Finkelstein reaction : fluorinase catalyses direct halogen exchange
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dc.contributor.author | Lowe, Phillip T. | |
dc.contributor.author | Cobb, Steven L. | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2020-07-24T23:36:06Z | |
dc.date.available | 2020-07-24T23:36:06Z | |
dc.date.issued | 2019-08-28 | |
dc.identifier.citation | Lowe , P T , Cobb , S L & O'Hagan , D 2019 , ' An enzymatic Finkelstein reaction : fluorinase catalyses direct halogen exchange ' , Organic & Biomolecular Chemistry , vol. 17 , no. 32 , pp. 7493-7496 . https://doi.org/10.1039/C9OB01625B | en |
dc.identifier.issn | 1477-0520 | |
dc.identifier.other | PURE: 260859368 | |
dc.identifier.other | PURE UUID: bc325925-d178-42c1-8535-efe9679f7c61 | |
dc.identifier.other | Bibtex: urn:f31175a170f124ab5f3933a18eca40d9 | |
dc.identifier.other | Scopus: 85070705601 | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/68281291 | |
dc.identifier.other | WOS: 000481416200008 | |
dc.identifier.other | ORCID: /0000-0003-1568-0750/work/122719953 | |
dc.identifier.uri | https://hdl.handle.net/10023/20336 | |
dc.description | We thank the Engineering and Physical Sciences Research Council, UK, for a research grant. | en |
dc.description.abstract | The fluorinase enzyme from Streptomyces cattleya is shown to catalyse a direct displacement of bromide and iodide by fluoride ion from 5′-bromodeoxyadenosine (5′-BrDA) and 5′-iododeoxyadenosine (5′-IDA) respectively to form 5′-fluorodeoxyadenosine (5′-FDA) in the absence of L-methionine (L-Met) or S-adenosyl-L-methionine (SAM). 5′-BrDA is the most efficient substrate for this enzyme catalysed Finkelstein reaction. | |
dc.format.extent | 4 | |
dc.language.iso | eng | |
dc.relation.ispartof | Organic & Biomolecular Chemistry | en |
dc.rights | Copyright © 2019 The Author(s). This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1039/C9OB01625B | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.title | An enzymatic Finkelstein reaction : fluorinase catalyses direct halogen exchange | en |
dc.type | Journal article | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | https://doi.org/10.1039/C9OB01625B | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2020-07-25 |
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