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dc.contributor.authorLowe, Phillip T.
dc.contributor.authorCobb, Steven L.
dc.contributor.authorO'Hagan, David
dc.date.accessioned2020-07-24T23:36:06Z
dc.date.available2020-07-24T23:36:06Z
dc.date.issued2019-08-28
dc.identifier.citationLowe , P T , Cobb , S L & O'Hagan , D 2019 , ' An enzymatic Finkelstein reaction : fluorinase catalyses direct halogen exchange ' , Organic & Biomolecular Chemistry , vol. 17 , no. 32 , pp. 7493-7496 . https://doi.org/10.1039/C9OB01625Ben
dc.identifier.issn1477-0520
dc.identifier.otherPURE: 260859368
dc.identifier.otherPURE UUID: bc325925-d178-42c1-8535-efe9679f7c61
dc.identifier.otherBibtex: urn:f31175a170f124ab5f3933a18eca40d9
dc.identifier.otherScopus: 85070705601
dc.identifier.otherORCID: /0000-0002-0510-5552/work/68281291
dc.identifier.otherWOS: 000481416200008
dc.identifier.otherORCID: /0000-0003-1568-0750/work/122719953
dc.identifier.urihttps://hdl.handle.net/10023/20336
dc.descriptionWe thank the Engineering and Physical Sciences Research Council, UK, for a research grant.en
dc.description.abstractThe fluorinase enzyme from Streptomyces cattleya is shown to catalyse a direct displacement of bromide and iodide by fluoride ion from 5′-bromodeoxyadenosine (5′-BrDA) and 5′-iododeoxyadenosine (5′-IDA) respectively to form 5′-fluorodeoxyadenosine (5′-FDA) in the absence of L-methionine (L-Met) or S-adenosyl-L-methionine (SAM). 5′-BrDA is the most efficient substrate for this enzyme catalysed Finkelstein reaction.
dc.format.extent4
dc.language.isoeng
dc.relation.ispartofOrganic & Biomolecular Chemistryen
dc.rightsCopyright © 2019 The Author(s). This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1039/C9OB01625Ben
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleAn enzymatic Finkelstein reaction : fluorinase catalyses direct halogen exchangeen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1039/C9OB01625B
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-07-25


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