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dc.contributor.authorPannebakker, Bart A.
dc.contributor.authorCook, Nicola
dc.contributor.authorvan den Heuvel, Joost
dc.contributor.authorvan de Zande, Louis
dc.contributor.authorShuker, David M.
dc.identifier.citationPannebakker , B A , Cook , N , van den Heuvel , J , van de Zande , L & Shuker , D M 2020 , ' Genomics of sex allocation in the parasitoid wasp Nasonia vitripennis ' , BMC Genomics , vol. 21 , 499 .
dc.identifier.otherPURE: 269273639
dc.identifier.otherPURE UUID: e35b1dc6-7fed-4a71-9ed6-47f115337498
dc.identifier.otherRIS: urn:5CA3E9E82EB283E0376B65CA0F317852
dc.identifier.otherRIS: Pannebakker2020
dc.identifier.otherORCID: /0000-0003-4462-0116/work/77893742
dc.identifier.otherWOS: 000553452100005
dc.identifier.otherScopus: 85088351906
dc.descriptionThis research was funded by the Netherlands Genomics Initiative (Zenith 93511041) and the by the Natural Environment Research Council (NE/J024481/1).en
dc.description.abstractBackground Whilst adaptive facultative sex allocation has been widely studied at the phenotypic level across a broad range of organisms, we still know remarkably little about its genetic architecture. Here, we explore the genome-wide basis of sex ratio variation in the parasitoid wasp Nasonia vitripennis, perhaps the best studied organism in terms of sex allocation, and well known for its response to local mate competition. Results We performed a genome-wide association study (GWAS) for single foundress sex ratios using iso-female lines derived from the recently developed outbred N. vitripennis laboratory strain HVRx. The iso-female lines capture a sample of the genetic variation in HVRx and we present them as the first iteration of the Nasonia vitripennis Genome Reference Panel (NVGRP 1.0). This panel provides an assessment of the standing genetic variation for sex ratio in the study population. Using the NVGRP, we discovered a cluster of 18 linked SNPs, encompassing 9 annotated loci associated with sex ratio variation. Furthermore, we found evidence that sex ratio has a shared genetic basis with clutch size on three different chromosomes. Conclusions Our approach provides a thorough description of the quantitative genetic basis of sex ratio variation in Nasonia at the genome level and reveals a number of inter-related candidate loci underlying sex allocation regulation.
dc.relation.ispartofBMC Genomicsen
dc.rightsCopyright © The Author(s). 2020 Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
dc.subjectLocal mate competitionen
dc.subjectParasitoid waspen
dc.subjectSex allocationen
dc.subjectGenetic reference panelen
dc.subjectSingle nucleotide polymorphism (SNP)en
dc.subjectGenome-wide association study (GWAS)en
dc.subjectQH426 Geneticsen
dc.titleGenomics of sex allocation in the parasitoid wasp Nasonia vitripennisen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biological Diversityen
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.description.statusPeer revieweden

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