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dc.contributor.authorCooper, Fergus R.
dc.contributor.authorBaker, Ruth E.
dc.contributor.authorBernabeu, Miguel O.
dc.contributor.authorBordas, Rafel
dc.contributor.authorBowler, Louise
dc.contributor.authorBueno-Orovio, Alfonso
dc.contributor.authorByrne, Helen M.
dc.contributor.authorCarapella, Valentina
dc.contributor.authorCardone-Noott, Louie
dc.contributor.authorCooper, Jonathan
dc.contributor.authorDutta, Sara
dc.contributor.authorEvans, Benjamin D.
dc.contributor.authorFletcher, Alexander G.
dc.contributor.authorGrogan, James A.
dc.contributor.authorGuo, Wenxian
dc.contributor.authorHarvey, Daniel G.
dc.contributor.authorHendrix, Maurice
dc.contributor.authorKay, David
dc.contributor.authorKursawe, Jochen
dc.contributor.authorMaini, Philip K.
dc.contributor.authorMcMillan, Beth
dc.contributor.authorMirams, Gary R.
dc.contributor.authorOsborne, James M.
dc.contributor.authorPathmanathan, Pras
dc.contributor.authorPitt-Francis, Joe M.
dc.contributor.authorRobinson, Martin
dc.contributor.authorRodriguez, Blanca
dc.contributor.authorSpiteri, Raymond J.
dc.contributor.authorGavaghan, David J.
dc.identifier.citationCooper , F R , Baker , R E , Bernabeu , M O , Bordas , R , Bowler , L , Bueno-Orovio , A , Byrne , H M , Carapella , V , Cardone-Noott , L , Cooper , J , Dutta , S , Evans , B D , Fletcher , A G , Grogan , J A , Guo , W , Harvey , D G , Hendrix , M , Kay , D , Kursawe , J , Maini , P K , McMillan , B , Mirams , G R , Osborne , J M , Pathmanathan , P , Pitt-Francis , J M , Robinson , M , Rodriguez , B , Spiteri , R J & Gavaghan , D J 2020 , ' Chaste : Cancer, Heart and Soft Tissue Environment ' , Journal of Open Source Software , vol. 5 , no. 47 , pp. 1848 .
dc.identifier.otherPURE: 268542608
dc.identifier.otherPURE UUID: 89066ac7-bf91-40d3-ac26-966316abc455
dc.identifier.otherBibtex: Cooper2020
dc.identifier.otherORCID: /0000-0002-0314-9623/work/75997048
dc.descriptionFunding: UK Engineering and Physical Sciences Research Council [grant number EP/N509711/1 (J.K.)].en
dc.description.abstractChaste (Cancer, Heart And Soft Tissue Environment) is an open source simulation package for the numerical solution of mathematical models arising in physiology and biology. To date, Chaste development has been driven primarily by applications that include continuum modelling of cardiac electrophysiology (‘Cardiac Chaste’), discrete cell-based modelling of soft tissues (‘Cell-based Chaste’), and modelling of ventilation in lungs (‘Lung Chaste’). Cardiac Chaste addresses the need for a high-performance, generic, and verified simulation framewor kfor cardiac electrophysiology that is freely available to the scientific community. Cardiac chaste provides a software package capable of realistic heart simulations that is efficient, rigorously tested, and runs on HPC platforms. Cell-based Chaste addresses the need for efficient and verified implementations of cell-based modelling frameworks, providing a set of extensible tools for simulating biological tissues. Computational modelling, along with live imaging techniques, plays an important role in understanding the processes of tissue growth and repair. A wide range of cell-based modelling frameworks have been developed that have each been successfully applied in a range of biological applications. Cell-based Chaste includes implementations of the cellular automaton model, the cellular Potts model, cell-centre models with cell representations as overlapping spheres or Voronoi tessellations, and the vertex model. Lung Chaste addresses the need for a novel, generic and efficient lung modelling software package that is both tested and verified. It aims to couple biophysically-detailed models of airway mechanics with organ-scale ventilation models in a package that is freely available to the scientific community.
dc.relation.ispartofJournal of Open Source Softwareen
dc.rightsCopyright © 2020 the Author(s). Authors of papers retain copyright and release the work under a Creative Commons Attribution 4.0 International License (CC-BY).en
dc.subjectQA75 Electronic computers. Computer scienceen
dc.subjectQH301 Biologyen
dc.subjectQP Physiologyen
dc.titleChaste : Cancer, Heart and Soft Tissue Environmenten
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.Applied Mathematicsen
dc.description.statusPeer revieweden

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