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dc.contributor.authorTrivić, Aleksandar
dc.contributor.authorCevik, Muge
dc.contributor.authorFolić, Miljan
dc.contributor.authorKrejovic-Trivić, Sanja
dc.contributor.authorRubino, Salvatore
dc.contributor.authorMicić, Jelena
dc.contributor.authorStevanović, Goran
dc.contributor.authorMilovanović, Jovica
dc.contributor.authorJotić, Ana
dc.contributor.authorBarać, Aleksandra
dc.date.accessioned2020-07-07T23:34:29Z
dc.date.available2020-07-07T23:34:29Z
dc.date.issued2019-07-08
dc.identifier260334979
dc.identifier496472ed-e38f-482d-a7bd-92e0fe65e756
dc.identifier31306351
dc.identifier85072746882
dc.identifier000509327000014
dc.identifier.citationTrivić , A , Cevik , M , Folić , M , Krejovic-Trivić , S , Rubino , S , Micić , J , Stevanović , G , Milovanović , J , Jotić , A & Barać , A 2019 , ' Management of orbital complications of acute rhinosinusitis in pediatric patients : a 15-Year single-center experience ' , Pediatric Infectious Disease Journal , vol. Online First . https://doi.org/10.1097/INF.0000000000002414en
dc.identifier.issn0891-3668
dc.identifier.otherORCID: /0000-0003-1133-3874/work/60196684
dc.identifier.urihttps://hdl.handle.net/10023/20217
dc.description.abstractBACKGROUND: The major clinical dilemma managing acute rhinosinusitis (ARS) in pediatric population is distinguishing uncomplicated rhinosinusitis from a complicated bacterial ARS and orbital complications, the latter requiring antimicrobials and surgical intervention. However, factors associated with severe orbital complications and the optimum management strategy remains controversial. The objectives of this study were to characterize the clinical outcomes of children with orbital complications of ARS and to identify risk factors associated with disease severity. METHODS: This retrospective cohort analysis evaluated the clinical outcomes of 61 children admitted for orbital complications between January 1, 2002 and December 31, 2017. Descriptive statistics were performed to examine the demographics and clinical findings. We compared groups using Mann-Whitney U test for continuous variables and χ for categorical variables. RESULTS: Although two-thirds of children had received prehospital antibiotics, half of the cohort presented with post-septal orbital complications. While 83% of isolates obtained from the same patients were susceptible to the prehospital antibiotics given, the majority of those who received prehospital antibiotics nevertheless required surgical intervention. We observed significant association between the age of presentation and disease severity. Children >5 years of age presented with more severe orbital complications despite prehospital antibiotics and were more likely to require surgical intervention (P < 0.001). CONCLUSIONS: In this study, stage II/III orbital complications at presentation and older age were the most important determinants of medical treatment failure. Early referral to eye, nose and throat (ENT) should be considered for children >5 years with ARS due to worse orbital complications despite prehospital antibiotics.
dc.format.extent401902
dc.language.isoeng
dc.relation.ispartofPediatric Infectious Disease Journalen
dc.subjectAcute rhinosinusitisen
dc.subjectOrbital complicationsen
dc.subjectPediatric; childrenen
dc.subjectChandler classificationen
dc.subjectRC Internal medicineen
dc.subjectRJ Pediatricsen
dc.subjectNDASen
dc.subject.lccRCen
dc.subject.lccRJen
dc.titleManagement of orbital complications of acute rhinosinusitis in pediatric patients : a 15-Year single-center experienceen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doi10.1097/INF.0000000000002414
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-07-08


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