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dc.contributor.authorCraig, Amy
dc.contributor.authorParvez, Faisal
dc.contributor.authorIssberner, Jon
dc.date.accessioned2020-06-26T23:35:41Z
dc.date.available2020-06-26T23:35:41Z
dc.date.issued2019-10-17
dc.identifier.citationCraig , A , Parvez , F & Issberner , J 2019 , ' A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer’s Disease in transgenic mice ' , Behavioural Brain Research , vol. 372 , 112015 . https://doi.org/10.1016/j.bbr.2019.112015en
dc.identifier.issn0166-4328
dc.identifier.otherPURE: 259473233
dc.identifier.otherPURE UUID: 7c6f49f7-b722-4040-9a1a-e69d11317103
dc.identifier.otherRIS: urn:8FEA1C7D20D3A258FE98D6A065D82476
dc.identifier.otherScopus: 85068240743
dc.identifier.otherWOS: 000478709300002
dc.identifier.urihttps://hdl.handle.net/10023/20167
dc.description.abstractClinical implication Alzheimer’s Disease (AD) presents as a gradual decline in cognitive function, with its characteristic pathology consisting of Amyloid β (Aβ) accumulation and hyperphosphorylated tau. Impaired insulin signalling was recently found in the brain in AD, and shown to increase AD pathology. Similar insulin resistance is found in type 2 diabetes and is currently treated with insulin sensitizers (IS). Aims and method The aim of this literature review was to evaluate whether IS could effectively reduce AD’s characteristic pathology and symptoms in models of AD in transgenic mice. The efficacy of an IS (Metformin, Rosiglitazone or Pioglitazone) at improving each characteristic in transgenic mice was evaluated. Results A variety of cognitive tests and measures of pathology were utilized to assess these outcomes, hindering comparison. Improvements in cognition, learning and Aβ pathology were demonstrated by some papers, and all papers reported a decrease in tau phosphorylation, but no effect on total tau levels.
dc.language.isoeng
dc.relation.ispartofBehavioural Brain Researchen
dc.rightsCopyright © 2019 Elsevier B.V. All rights reserved. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.bbr.2019.112015en
dc.subjectInsulin sensitizeren
dc.subjectMetforminen
dc.subjectThiazolidinedionesen
dc.subjectAlzheimer’s diseaseen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccRC0321en
dc.titleA systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer’s Disease in transgenic miceen
dc.typeJournal itemen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. Education Divisionen
dc.contributor.institutionUniversity of St Andrews. Office of the Principalen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doihttps://doi.org/10.1016/j.bbr.2019.112015
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-06-27


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