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dc.contributor.authorFraile Navarro, David
dc.contributor.authorSullivan, Francis
dc.contributor.authorAzcoaga-Lorenzo, Amaya
dc.contributor.authorHernandez Santiago, Virginia
dc.identifier.citationFraile Navarro , D , Sullivan , F , Azcoaga-Lorenzo , A & Hernandez Santiago , V 2020 , ' Point-of-care tests for urinary tract infections : protocol for a systematic review and meta-analysis of diagnostic test accuracy ' , BMJ Open , vol. 10 , no. 6 , e033424 .
dc.identifier.otherORCID: /0000-0002-8544-1483/work/75610493
dc.identifier.otherORCID: /0000-0003-3307-878X/work/75610544
dc.identifier.otherORCID: /0000-0002-1108-7071/work/75610548
dc.identifier.otherORCID: /0000-0002-6623-4964/work/75610458
dc.descriptionFunding: DFN is supported by an NES general practice academic fellowship, AAL is supported by an HDR UK clinical postdoctoral fellowship and VHS is supported by an NRS clinical academic fellowship.en
dc.description.abstractIntroduction Urinary tract infections (UTIs) are the second most common type of infection worldwide, accounting for a large number of primary care consultations and antibiotic prescribing. Current diagnosis is based on an empirical approach, relying on symptoms and occasional use of urine dipsticks. The diagnostic reference standard is still urine culture, although it is not routinely recommended for uncomplicated UTIs in the community, due to time to diagnosis (48 hours). Faster point-of-care tests have been developed, but their diagnostic accuracy has not been compared. Our objective is to systematically review and meta-analyse the diagnostic accuracy of currently available point-of-care tests for UTIs. Methods and analysis Studies evaluating the diagnostic accuracy of point-of-care tests for UTIs will be included. PubMed, Web of Science, Embase and Cochrane Database of Systematic Reviews were searched from inception to 1 June 2019. Data extraction and risk-of-bias assessment will be assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. Meta-analysis will be performed depending on data availability and heterogeneity. Ethics and dissemination This is a systematic review protocol and therefore formal ethical approval is not required, as no primary, identifiable, personal data will be collected. Patients or the public were not involved in the design of our research. However, the findings from this review will be shared with key stakeholders, including patient groups, clinicians and guideline developers, and will also be presented and national and international conferences.
dc.relation.ispartofBMJ Openen
dc.subjectRC Internal medicineen
dc.titlePoint-of-care tests for urinary tract infections : protocol for a systematic review and meta-analysis of diagnostic test accuracyen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. Population and Behavioural Science Divisionen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.description.statusPeer revieweden

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