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dc.contributor.authorWang, Jiachao
dc.contributor.authorTait, David S.
dc.contributor.authorBrown, Verity J.
dc.contributor.authorBowman, Eric M.
dc.date.accessioned2020-06-12T23:34:48Z
dc.date.available2020-06-12T23:34:48Z
dc.date.issued2019-10-17
dc.identifier259340607
dc.identifier7b48efb5-0812-4e4f-9f1f-97bef77aa79b
dc.identifier31202862
dc.identifier85067860035
dc.identifier000478709300027
dc.identifier.citationWang , J , Tait , D S , Brown , V J & Bowman , E M 2019 , ' Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning ' , Behavioural Brain Research , vol. 372 , 112037 . https://doi.org/10.1016/j.bbr.2019.112037en
dc.identifier.issn0166-4328
dc.identifier.otherORCID: /0000-0001-9693-1739/work/60195381
dc.identifier.otherORCID: /0000-0001-5310-7731/work/60195429
dc.identifier.otherORCID: /0000-0001-5762-1797/work/63380676
dc.identifier.urihttps://hdl.handle.net/10023/20078
dc.descriptionFunding: JW received a PhD scholarship from the University of St Andrews.en
dc.description.abstractOur internal models of the world help us to process information rapidly: in general model-based learning is more rapid than model-free learning. However, the cognitive flexibility required to overcome cognitive predispositions can let us down: it is not fully developed until adulthood; predispositions can be unconscious biases; and cognitive flexibility is impaired in many psychiatric and neurological conditions. To understand these limits to flexibility, we need to know how brain generates predispositions and deploys flexibility. We performed a detailed analysis of the exploratory behavior of rats in the pre-solution period of a two-alternative forced choice discrimination learning task. Rats readily learn in which of two bowls, filled with differentially scented and textured digging materials, there is hidden bait. In a single session, they are presented with a series of discrimination learning and reversal stages. We performed a simple Bayesian analysis on the data from 68 rats, 33 of which had lesions of the medial prefrontal cortex), to examine patterns of responding in the pre-solution period. Control rats rapidly focussed on the relevant stimulus attributes and showed flexibility when required to learn about a different stimulus attribute. Rats with prefrontal cortex damage had reduced sensitivity to negative feedback. They were able to overcome this deficit and solve the credit assignment problem when there were limited alternatives or when attention was appropriately focused and predispositions matched the required response. However, the learning impairment presents as a problem with shifting attention due to the additional difficulty of solving the credit assignment problem when the attentional set is inconsistent with the required response.
dc.format.extent943209
dc.language.isoeng
dc.relation.ispartofBehavioural Brain Researchen
dc.subjectPrefrontal cortexen
dc.subjectSet-shiftingen
dc.subjectExecutive functionen
dc.subjectBayesen
dc.subjectLearningen
dc.subjectBF Psychologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject.lccBFen
dc.subject.lccRC0321en
dc.titleExacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learningen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.identifier.doi10.1016/j.bbr.2019.112037
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-06-13


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