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dc.contributor.authorWest, Matthew J.
dc.contributor.authorWatson, Allan J. B.
dc.date.accessioned2020-04-28T23:34:03Z
dc.date.available2020-04-28T23:34:03Z
dc.date.issued2019-05-28
dc.identifier258978911
dc.identifiere92a412d-166f-4cf9-acfc-554c6b0abebf
dc.identifier85066129046
dc.identifier000468790100014
dc.identifier.citationWest , M J & Watson , A J B 2019 , ' Ni vs . Pd in Suzuki-Miyaura sp 2 -sp 2 cross-coupling : a head-to-head study in a comparable precatalyst/ligand system ' , Organic & Biomolecular Chemistry , vol. 17 , no. 20 , pp. 5055-5059 . https://doi.org/10.1039/C9OB00561Gen
dc.identifier.issn1477-0520
dc.identifier.otherORCID: /0000-0002-1582-4286/work/62668490
dc.identifier.urihttps://hdl.handle.net/10023/19866
dc.descriptionWe thank the University of St Andrews for a PhD studentship (MJW).en
dc.description.abstractThe Suzuki-Miyaura reaction is a cornerstone method for sp2-sp2 cross-coupling in industry. There has been a concerted effort to enable the use of Ni catalysis as an alternative to Pd in order to mitigate cost and improve sustainability. Despite significant advances, ligand development for Ni-catalyzed Suzuki-Miyaura cross-coupling remains underdeveloped when compared to Pd and, as a consequence, ligands for Ni-catalyzed processes are typically taken from the Pd arena. In this study we evaluate the effect of using a similar Ni and Pd precatalyst based on a common bidentate ligand (dppf) in a head-to-head format for the most common type of biaryl couplings, establishing the practical implications of direct replacement of Pd with Ni, and identifying the potential origins of these observations in a mechanistic context.
dc.format.extent489506
dc.language.isoeng
dc.relation.ispartofOrganic & Biomolecular Chemistryen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleNi vs. Pd in Suzuki-Miyaura sp2-sp2 cross-coupling : a head-to-head study in a comparable precatalyst/ligand systemen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.identifier.doi10.1039/C9OB00561G
dc.description.statusPeer revieweden
dc.date.embargoedUntil2020-04-29


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