Show simple item record

Files in this item


Item metadata

dc.contributor.authorWest, Matthew J.
dc.contributor.authorWatson, Allan J. B.
dc.identifier.citationWest , M J & Watson , A J B 2019 , ' Ni vs . Pd in Suzuki-Miyaura sp 2 -sp 2 cross-coupling : a head-to-head study in a comparable precatalyst/ligand system ' , Organic & Biomolecular Chemistry , vol. 17 , no. 20 , pp. 5055-5059 .
dc.identifier.otherPURE: 258978911
dc.identifier.otherPURE UUID: e92a412d-166f-4cf9-acfc-554c6b0abebf
dc.identifier.otherScopus: 85066129046
dc.identifier.otherWOS: 000468790100014
dc.identifier.otherORCID: /0000-0002-1582-4286/work/62668490
dc.descriptionWe thank the University of St Andrews for a PhD studentship (MJW).en
dc.description.abstractThe Suzuki-Miyaura reaction is a cornerstone method for sp2-sp2 cross-coupling in industry. There has been a concerted effort to enable the use of Ni catalysis as an alternative to Pd in order to mitigate cost and improve sustainability. Despite significant advances, ligand development for Ni-catalyzed Suzuki-Miyaura cross-coupling remains underdeveloped when compared to Pd and, as a consequence, ligands for Ni-catalyzed processes are typically taken from the Pd arena. In this study we evaluate the effect of using a similar Ni and Pd precatalyst based on a common bidentate ligand (dppf) in a head-to-head format for the most common type of biaryl couplings, establishing the practical implications of direct replacement of Pd with Ni, and identifying the potential origins of these observations in a mechanistic context.
dc.relation.ispartofOrganic & Biomolecular Chemistryen
dc.rightsCopyright © 2019 The Author(s). This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at
dc.subjectQD Chemistryen
dc.titleNi vs. Pd in Suzuki-Miyaura sp2-sp2 cross-coupling : a head-to-head study in a comparable precatalyst/ligand systemen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.description.statusPeer revieweden

This item appears in the following Collection(s)

Show simple item record