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dc.contributor.authorCortés-Ciriano, Isidro
dc.contributor.authorLee, Jake June-Koo
dc.contributor.authorXi, Ruibin
dc.contributor.authorJain, Dhawal
dc.contributor.authorJung, Youngsook L.
dc.contributor.authorYang, Lixing
dc.contributor.authorGordenin, Dmitry
dc.contributor.authorKlimczak, Leszek J.
dc.contributor.authorZhang, Cheng-Zhong
dc.contributor.authorPellman, David S.
dc.contributor.authorPCAWG Structural Variation Working Group
dc.contributor.authorPark, Peter J.
dc.contributor.authorPCAWG Consortium
dc.date.accessioned2020-04-23T09:30:02Z
dc.date.available2020-04-23T09:30:02Z
dc.date.issued2020-03
dc.identifier.citationCortés-Ciriano , I , Lee , J J-K , Xi , R , Jain , D , Jung , Y L , Yang , L , Gordenin , D , Klimczak , L J , Zhang , C-Z , Pellman , D S , PCAWG Structural Variation Working Group , Park , P J & PCAWG Consortium 2020 , ' Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing ' , Nature Genetics , vol. 52 , no. 3 , pp. 331-341 . https://doi.org/10.1038/s41588-019-0576-7en
dc.identifier.issn1061-4036
dc.identifier.otherPURE: 267565788
dc.identifier.otherPURE UUID: 7a9a3e37-8d58-428c-acca-8f57bce882fe
dc.identifier.otherScopus: 85079044799
dc.identifier.otherPubMed: 32025003
dc.identifier.otherORCID: /0000-0002-7876-7338/work/72842788
dc.identifier.otherWOS: 000511282900004
dc.identifier.urihttp://hdl.handle.net/10023/19844
dc.descriptionThis work was supported by the European Union’s Framework Programme For Research and Innovation Horizon 2020 under the Marie Sklodowska-Curie grant agreement no. 703543 (I.C.-C.), the Ludwig Center at Harvard (I.C.-C., J.J.-K.L. and P.J.P.), K22CA193848 (L.Y.), R01CA213404 (D.S.P.) and the US National Institutes of Health Intramural Research Program Project Z1AES103266 (D.G. and L.J.K.). We thank the Research Information Technology Group at Harvard Medical School for providing computational resources and S. Ouellette in the Park laboratory for help in deploying the companion website. We acknowledge the contributions of the many clinical networks across ICGC and TCGA, who provided samples and data to the PCAWG Consortium, and the contributions of the Technical Working Group and the Germline Working Group of the PCAWG Consortium for collation, realignment and harmonized variant calling of the cancer genomes used in this study. We thank the patients and their families for their participation in the individual ICGC and TCGA projects.en
dc.description.abstractChromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other diseases. Recent studies in selected cancer types have suggested that chromothripsis may be more common than initially inferred from low-resolution copy-number data. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we analyze patterns of chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find that chromothripsis events are pervasive across cancers, with a frequency of more than 50% in several cancer types. Whereas canonical chromothripsis profiles display oscillations between two copy-number states, a considerable fraction of events involve multiple chromosomes and additional structural alterations. In addition to non-homologous end joining, we detect signatures of replication-associated processes and templated insertions. Chromothripsis contributes to oncogene amplification and to inactivation of genes such as mismatch-repair-related genes. These findings show that chromothripsis is a major process that drives genome evolution in human cancer.
dc.language.isoeng
dc.relation.ispartofNature Geneticsen
dc.rightsCopyright © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adap-tation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statu-tory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectCanceren
dc.subjectComputational biology and bioinformaticsen
dc.subjectGenomicsen
dc.subjectQH426 Geneticsen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectGeneticsen
dc.subject3rd-DASen
dc.subject.lccQH426en
dc.subject.lccRC0254en
dc.titleComprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencingen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.contributor.institutionUniversity of St Andrews. Statisticsen
dc.contributor.institutionUniversity of St Andrews. Sir James Mackenzie Institute for Early Diagnosisen
dc.contributor.institutionUniversity of St Andrews. Cellular Medicine Divisionen
dc.identifier.doihttps://doi.org/10.1038/s41588-019-0576-7
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.nature.com/articles/s41588-020-0634-1en


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