Microlaser-based contractility sensing in single cardiomyocytes and whole hearts
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Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.
Schubert , M , Woolfson , L , Barnard , I R M , Morton , A , Casement , B , Robertson , G B , Miles , G B , Pitt , S J , Tucker , C S & Gather , M C 2019 , Microlaser-based contractility sensing in single cardiomyocytes and whole hearts . in A Amelink & S K Nadkarni (eds) , Novel biophotonics techniques and applications V . , 110750C , Progress in Biomedical Optics and Imaging - Proceedings of SPIE , vol. 11075 , SPIE , European Conferences on Biomedical Optics , Munich , Germany , 23/06/19 . https://doi.org/10.1117/12.2526955conference
Novel biophotonics techniques and applications V
Copyright © (2019) Society of Photo-Optical Instrumentation Engineers (SPIE). This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1117/12.2526955
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