Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

Schubert, Marcel; Woolfson, Lewis; Barnard, Isla R.M.; Morton, Andrew; Casement, Becky; Robertson, Gavin B.; Miles, Gareth B.; Pitt, Samantha J.; Tucker, Carl S.; Gather, Malte C.

Abstract

Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.

Citation

Schubert , M , Woolfson , L , Barnard , I R M , Morton , A , Casement , B , Robertson , G B , Miles , G B , Pitt , S J , Tucker , C S & Gather , M C 2019 , Microlaser-based contractility sensing in single cardiomyocytes and whole hearts . in A Amelink & S K Nadkarni (eds) , Novel biophotonics techniques and applications V . , 110750C , Progress in Biomedical Optics and Imaging - Proceedings of SPIE , vol. 11075 , SPIE , European Conferences on Biomedical Optics , Munich , Germany , 23/06/19 . https://doi.org/10.1117/12.2526955

conference

Publication

Novel biophotonics techniques and applications V

DOI

https://doi.org/10.1117/12.2526955

ISSN

1605-7422

Type

Conference item

Rights

Copyright © (2019) Society of Photo-Optical Instrumentation Engineers (SPIE). This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1117/12.2526955

Collections

University of St Andrews Research

URI

http://hdl.handle.net/10023/19623

St Andrews Research Repository