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Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

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Schubert_et_al_Biophotonics_Congress_2019.pdf (3.180Mb)
Date
22/07/2019
Author
Schubert, Marcel
Woolfson, Lewis
Barnard, Isla R.M.
Morton, Andrew
Casement, Becky
Robertson, Gavin B.
Miles, Gareth B.
Pitt, Samantha J.
Tucker, Carl S.
Gather, Malte C.
Keywords
QC Physics
T Technology (General)
Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging
NS
BDC
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Abstract
Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.
Citation
Schubert , M , Woolfson , L , Barnard , I R M , Morton , A , Casement , B , Robertson , G B , Miles , G B , Pitt , S J , Tucker , C S & Gather , M C 2019 , Microlaser-based contractility sensing in single cardiomyocytes and whole hearts . in A Amelink & S K Nadkarni (eds) , Novel biophotonics techniques and applications V . , 110750C , Progress in Biomedical Optics and Imaging - Proceedings of SPIE , vol. 11075 , SPIE , European Conferences on Biomedical Optics , Munich , Germany , 23/06/19 . https://doi.org/10.1117/12.2526955
 
conference
 
Publication
Novel biophotonics techniques and applications V
DOI
https://doi.org/10.1117/12.2526955
ISSN
1605-7422
Type
Conference item
Rights
Copyright © (2019) Society of Photo-Optical Instrumentation Engineers (SPIE). This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1117/12.2526955
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/19623

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