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dc.contributor.authorMazur , Leszek Mateusz
dc.contributor.authorRoland, Thomas
dc.contributor.authorLeroy-Lhez, Stephanie
dc.contributor.authorSol, Vincent
dc.contributor.authorSamoc, Marek
dc.contributor.authorSamuel, Ifor David William
dc.contributor.authorMatczyszyn, Katarzyna
dc.identifier.citationMazur , L M , Roland , T , Leroy-Lhez , S , Sol , V , Samoc , M , Samuel , I D W & Matczyszyn , K 2019 , ' Efficient singlet oxygen photogeneration by zinc porphyrin-dimers upon one- and two-photon excitation ' , Journal of Physical Chemistry B , vol. 123 , no. 19 , pp. 4271-4277 .
dc.descriptionFunding: UK EPSRC (EP/L017008/1), IDWS acknowledges a Royal Society Wolfson Research Merit Award. This work is a part of the ITN-EJD-2017 project POLYTHEA which has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 764837.en
dc.description.abstractThe development of photodynamic therapy at depth requires photosensitizers which have both sufficient quantum yield for singlet oxygen generation and strong two photon absorption. Here we show that this can be achieved by conjugated linkage of zinc porphyrins to make dimers. We determined the quantum yield of generation of 1O2, φΔ , by measuring emission at 1270 nm using a near infra-red streak camera and found it to increase from 15% for a single porphyrin unit to 27 47% for the dimers with a conjugated linker. Then, we measured the spectra of two-photon absorption cross section, σ2, by a focus-tunable Z scan method, which allows for nondestructive investigation of light-sensitive materials. We observed a strong enhancement of the two photon absorption coefficient in the dimers, especially those with an alkyne linker. These results lead to an excellent figure of merit for two photon production of singlet oxygen (expressed by the product σ2xφΔ) in the porphyrin dimers, of around 3700 GM, which is very promising for applications involving treatment of deep tumors by photodynamic therapy.
dc.relation.ispartofJournal of Physical Chemistry Ben
dc.subjectQC Physicsen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleEfficient singlet oxygen photogeneration by zinc porphyrin-dimers upon one- and two-photon excitationen
dc.typeJournal articleen
dc.contributor.sponsorThe Royal Societyen
dc.contributor.institutionUniversity of St Andrews. Condensed Matter Physicsen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. Centre for Biophotonicsen
dc.description.statusPeer revieweden

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