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Perinatal complications in female survivors of cancer : a systematic review and meta-analysis
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dc.contributor.author | van der Kooi, Anne Lotte | |
dc.contributor.author | Kelsey, Thomas William | |
dc.contributor.author | van den Heuvel-Eibrink, Marry | |
dc.contributor.author | Laven, Joop S. E. | |
dc.contributor.author | Wallace, W. Hamish B. | |
dc.contributor.author | Anderson, Richard A. | |
dc.date.accessioned | 2020-03-05T00:31:56Z | |
dc.date.available | 2020-03-05T00:31:56Z | |
dc.date.issued | 2019-04 | |
dc.identifier | 257498619 | |
dc.identifier | 40d6b54f-b718-4305-9c9e-5a541be7a8ea | |
dc.identifier | 85062399219 | |
dc.identifier | 000462035200015 | |
dc.identifier.citation | van der Kooi , A L , Kelsey , T W , van den Heuvel-Eibrink , M , Laven , J S E , Wallace , W H B & Anderson , R A 2019 , ' Perinatal complications in female survivors of cancer : a systematic review and meta-analysis ' , European Journal of Cancer , vol. 111 , pp. 126-137 . https://doi.org/10.1016/j.ejca.2019.01.104 | en |
dc.identifier.issn | 0959-8049 | |
dc.identifier.other | ORCID: /0000-0002-8091-1458/work/58755469 | |
dc.identifier.uri | https://hdl.handle.net/10023/19598 | |
dc.description | Funding: Ter Meulen Grant of the Royal Netherlands Academy of Arts and Sciences and the European Union’s Seventh Framework Programme for research, technological developmentand demonstration under grant agreement no 602030 (A.L.F.v.d.K.). | en |
dc.description.abstract | Background: Observational studies have suggested that perinatal outcomes are worse in offspring of cancer survivors. We conducted a systematic review and meta-analysis to examine the risks of perinatal complications in female cancer survivors diagnosed before the age of 40 years. Methods: All published articles on pregnancy, perinatal or congenital risks in female cancer survivors were screened for eligibility. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Results: Twenty-two studies met the inclusion criteria. Meta-analysis indicates that offspring of cancer survivors are at increased risk of prematurity (relative risk [RR]: 1.56; 95% confidence interval [CI] 1.37–1.77) and low birth weight (RR 1.47; 95% CI 1.24–1.73) but not of being small for gestational age (RR 0.99; 95% CI 0.81–1.22). Cancer survivors have higher rates of elective (RR: 1.38; 95% CI 1.13–1.70) and emergency caesarean section (RR: 1.22; 95% CI 1.15–1.30) as well as assisted vaginal delivery (RR: 1.10; 95% CI 1.02–1.18) and are at increased risk of postpartum haemorrhage (RR: 1.18; 95% CI 1.02–1.36). The risk of congenital abnormalities also appears increased (RR 1.10; 95% CI 1.02–1.20), but this is likely to be an artefact of analysis. Although meta-analysis of the effects of radiotherapy was not possible for all outcomes, there was an increased risk of prematurity (RR 2.27; 95% CI 1.34–3.82) and consistent findings of low birth weight (RR 1.38–2.31). Risk of being small for gestational age was increased only after high uterine radiotherapy dosage. Conclusion: The increased perinatal risks warrant a proactive approach from healthcare providers in both counselling and management of perinatal care for cancer survivors. | |
dc.format.extent | 214742 | |
dc.language.iso | eng | |
dc.relation.ispartof | European Journal of Cancer | en |
dc.subject | Cancer survivors | en |
dc.subject | Perinatal risk | en |
dc.subject | Premature delivery | en |
dc.subject | Postpartum haemorrhage | en |
dc.subject | Low birth weight | en |
dc.subject | Congenital abnormalities | en |
dc.subject | RC0254 Neoplasms. Tumors. Oncology (including Cancer) | en |
dc.subject | RG Gynecology and obstetrics | en |
dc.subject | NDAS | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RC0254 | en |
dc.subject.lcc | RG | en |
dc.title | Perinatal complications in female survivors of cancer : a systematic review and meta-analysis | en |
dc.type | Journal article | en |
dc.contributor.institution | University of St Andrews. School of Computer Science | en |
dc.contributor.institution | University of St Andrews. Centre for Interdisciplinary Research in Computational Algebra | en |
dc.identifier.doi | 10.1016/j.ejca.2019.01.104 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2020-03-05 |
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