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dc.contributor.authorDong, L. I.
dc.contributor.authorWijesinghe, Philip
dc.contributor.authorSampson, David D.
dc.contributor.authorKennedy, Brendan F.
dc.contributor.authorMunro, Peter R.T.
dc.contributor.authorOberai, Assad A.
dc.identifier.citationDong , L I , Wijesinghe , P , Sampson , D D , Kennedy , B F , Munro , P R T & Oberai , A A 2019 , ' Volumetric quantitative optical coherence elastography with an iterative inversion method ' , Biomedical Optics Express , vol. 10 , no. 2 , pp. 384-398 .
dc.identifier.otherPURE: 266560693
dc.identifier.otherPURE UUID: 668198dc-2794-4c6c-b738-28ebf4a7583f
dc.identifier.otherScopus: 85061536045
dc.identifier.otherORCID: /0000-0002-8378-7261/work/69835211
dc.description.abstractIt is widely accepted that accurate mechanical properties of three-dimensional soft tissues and cellular samples are not available on the microscale. Current methods based on optical coherence elastography can measure displacements at the necessary resolution, and over the volumes required for this task. However, in converting this data to maps of elastic properties, they often impose assumptions regarding homogeneity in stress or elastic properties that are violated in most realistic scenarios. Here, we introduce novel, rigorous, and computationally efficient inverse problem techniques that do not make these assumptions, to realize quantitative volumetric elasticity imaging on the microscale. Specifically, we iteratively solve the three-dimensional elasticity inverse problem using displacement maps obtained from compression optical coherence elastography. This is made computationally feasible with adaptive mesh refinement and domain decomposition methods. By employing a transparent, compliant surface layer with known shear modulus as a reference for the measurement, absolute shear modulus values are produced within a millimeter-scale sample volume. We demonstrate the method on phantoms, on a breast cancer sample ex vivo, and on human skin in vivo. Quantitative elastography on this length scale will find wide application in cell biology, tissue engineering and medicine.
dc.relation.ispartofBiomedical Optics Expressen
dc.rightsCopyright © 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the final published version of the work, which was originally published at
dc.subjectAtomic and Molecular Physics, and Opticsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleVolumetric quantitative optical coherence elastography with an iterative inversion methoden
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.description.statusPeer revieweden

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