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dc.contributor.authorDong, L. I.
dc.contributor.authorWijesinghe, Philip
dc.contributor.authorSampson, David D.
dc.contributor.authorKennedy, Brendan F.
dc.contributor.authorMunro, Peter R.T.
dc.contributor.authorOberai, Assad A.
dc.date.accessioned2020-03-03T13:30:02Z
dc.date.available2020-03-03T13:30:02Z
dc.date.issued2019-02-01
dc.identifier266560693
dc.identifier668198dc-2794-4c6c-b738-28ebf4a7583f
dc.identifier85061536045
dc.identifier.citationDong , L I , Wijesinghe , P , Sampson , D D , Kennedy , B F , Munro , P R T & Oberai , A A 2019 , ' Volumetric quantitative optical coherence elastography with an iterative inversion method ' , Biomedical Optics Express , vol. 10 , no. 2 , pp. 384-398 . https://doi.org/10.1364/BOE.10.000384en
dc.identifier.issn2156-7085
dc.identifier.otherORCID: /0000-0002-8378-7261/work/69835211
dc.identifier.urihttps://hdl.handle.net/10023/19587
dc.description.abstractIt is widely accepted that accurate mechanical properties of three-dimensional soft tissues and cellular samples are not available on the microscale. Current methods based on optical coherence elastography can measure displacements at the necessary resolution, and over the volumes required for this task. However, in converting this data to maps of elastic properties, they often impose assumptions regarding homogeneity in stress or elastic properties that are violated in most realistic scenarios. Here, we introduce novel, rigorous, and computationally efficient inverse problem techniques that do not make these assumptions, to realize quantitative volumetric elasticity imaging on the microscale. Specifically, we iteratively solve the three-dimensional elasticity inverse problem using displacement maps obtained from compression optical coherence elastography. This is made computationally feasible with adaptive mesh refinement and domain decomposition methods. By employing a transparent, compliant surface layer with known shear modulus as a reference for the measurement, absolute shear modulus values are produced within a millimeter-scale sample volume. We demonstrate the method on phantoms, on a breast cancer sample ex vivo, and on human skin in vivo. Quantitative elastography on this length scale will find wide application in cell biology, tissue engineering and medicine.
dc.format.extent15
dc.format.extent4963780
dc.language.isoeng
dc.relation.ispartofBiomedical Optics Expressen
dc.subjectBiotechnologyen
dc.subjectAtomic and Molecular Physics, and Opticsen
dc.subjectNDASen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleVolumetric quantitative optical coherence elastography with an iterative inversion methoden
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.identifier.doi10.1364/BOE.10.000384
dc.description.statusPeer revieweden
dc.identifier.urlhttps://www.osapublishing.org/boe/abstract.cfm?uri=boe-10-2-384en


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