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dc.contributor.authorAllen, Wes M.
dc.contributor.authorWijesinghe, Philip
dc.contributor.authorDessauvagie, Benjamin F.
dc.contributor.authorLatham, Bruce
dc.contributor.authorSaunders, Christobel M.
dc.contributor.authorKennedy, Brendan F.
dc.date.accessioned2020-02-28T15:30:11Z
dc.date.available2020-02-28T15:30:11Z
dc.date.issued2019-01
dc.identifier.citationAllen , W M , Wijesinghe , P , Dessauvagie , B F , Latham , B , Saunders , C M & Kennedy , B F 2019 , ' Optical palpation for the visualization of tumor in human breast tissue ' , Journal of Biophotonics , vol. 12 , no. 1 , e201800180 . https://doi.org/10.1002/jbio.201800180en
dc.identifier.issn1864-063X
dc.identifier.otherPURE: 266562495
dc.identifier.otherPURE UUID: 44694377-a350-47f9-94d7-a3eed8065506
dc.identifier.otherScopus: 85052841993
dc.identifier.otherORCID: /0000-0002-8378-7261/work/69835207
dc.identifier.urihttp://hdl.handle.net/10023/19555
dc.descriptionAustralian Research Council; Cancer Council Western Australia; Department of Health, Government of Western Australia; OncoResMedical; William and Marlene Schrader Trust of The University of Western Australiaen
dc.description.abstractAccurate and effective removal of tumor in one operation is an important goal of breast-conserving surgery. However, it is not always achieved. Surgeons often utilize manual palpation to assess the surgical margin and/or the breast cavity. Manual palpation, however, is subjective and has relatively low resolution. Here, we investigate a tactile imaging technique, optical palpation, for the visualization of tumor. Optical palpation generates maps of the stress at the surface of tissue under static preload compression. Stress is evaluated by measuring the deformation of a contacting thin compliant layer with known mechanical properties using optical coherence tomography. In this study, optical palpation is performed on 34 freshly excised human breast specimens. Wide field-of-view (up to ~46 × 46 mm) stress images, optical palpograms, are presented from four representative specimens, demonstrating the capability of optical palpation to visualize tumor. Median stress reported for adipose tissue, 4 kPa, and benign dense tissue, 8 kPa, is significantly lower than for invasive tumor, 60 kPa. In addition, we demonstrate that optical palpation provides contrast consistent with a related optical technique, quantitative micro-elastography. This study demonstrates that optical palpation holds promise for visualization of tumor in breast-conserving surgery.
dc.format.extent11
dc.language.isoeng
dc.relation.ispartofJournal of Biophotonicsen
dc.rightsCopyright © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/jbio.201800180en
dc.subjectBreast-conserving surgeryen
dc.subjectOptical coherence tomographyen
dc.subjectOptical palpationen
dc.subjectTactile imagingen
dc.subjectTumor margin assessmenten
dc.subjectQC Physicsen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectChemistry(all)en
dc.subjectBiochemistry, Genetics and Molecular Biology(all)en
dc.subjectEngineering(all)en
dc.subjectMaterials Science(all)en
dc.subjectPhysics and Astronomy(all)en
dc.subjectT-NDASen
dc.subject.lccQCen
dc.subject.lccRC0254en
dc.titleOptical palpation for the visualization of tumor in human breast tissueen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.identifier.doihttps://doi.org/10.1002/jbio.201800180
dc.description.statusPeer revieweden


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